Structure-activity relationships for saponins from Allium hirtifolium and allium elburzense and their antispasmodic activity

Planta Medica

Volumn 71, Issue 11, 2005, Pages 1010-1018

  Barile, Elisa ^a   Capasso, Raffaele ^b   Izzo, Angelo A ^b   Lanzotti, Virginia ^a   Sajjadi, S Ebrahim ^c   Zolfaghari, Behzad ^c  

^a UNIVERSITY OF MOLISE   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Allium; Antispasmodic activity; Elburzensosides; Flavonol glycosides; Hirtifoliosicles; Terpenoids

Indexed keywords

AGAPANTHAGENIN; AGAPANTHAGENIN 3 O BETA DEXTRO GLUCOPYRANOSIDE; ALLIOGENIN 3 O BETA DEXTRO GLUCOPYRANOSIDE; ALLIUM ELBURZENSE EXTRACT; ALLIUM HIRTIFOLIUM EXTRACT; DIGESTIVE TRACT SPASMOLYTIC AGENT; ELBURZENSOSIDE C1; ELBURZENSOSIDE C2; FLAVONOID GLYCOSIDE; GITOGENIN 3 O BETA DEXTRO GLUCOPYRANOSYL(1-4) O BETA DEXTRO GLUCOPYRANOSIDE; GLUCOSE; HIRTIFOLIOSIDE A1; HIRTIFOLIOSIDE A2; HIRTIFOLIOSIDE B; HIRTIFOLIOSIDE C1; HIRTIFOLIOSIDE C2; HIRTIFOLIOSIDE D; HYDROXYL GROUP; KAEMPFEROL 3 O BETA DEXTRO GLUCOPYRANOSYL(1-4) GLUCOPYRANOSIDE; KAEMPFEROL 3 O BETA DEXTRO RHAMNOPYRANOSYL(1-2) GLUCOPYRANOSIDE; KAEMPFEROL 3 O GLUCOPYRANOSIDE; KAEMPFEROL 7 O GLUCOPYRANOSIDE; PLANT EXTRACT; SAPONIN DERIVATIVE; SPIROSTAN DERIVATIVE; UNCLASSIFIED DRUG;

ALLIUM ELBURZENSE; ALLIUM HIRTIFOLIUM; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DETERMINATION; DRUG ISOLATION; FLOWER; GARLIC; GASTROINTESTINAL DISEASE; GUINEA PIG; HISTAMINE RELEASE; ILEUM CONTRACTION; MALE; MEDICINAL PLANT; NONHUMAN; ONION; PHYTOCHEMISTRY; PLANT BULB; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ALLIUM; ANIMALS; GUINEA PIGS; ILEUM; MALE; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; PARASYMPATHOLYTICS; SAPONINS; STRUCTURE-ACTIVITY RELATIONSHIP;

ALLIUM; ALLIUM CEPA; ALLIUM HIRTIFOLIUM; ALLIUM SATIVUM; ANIMALIA; CAVIA PORCELLUS;

EID: 29144536739     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-873134     Document Type: Article

References (22)

1. Achem SR. Treatment of spastic esophageal motility disorders. Gastroenterol Clin North Am 2004; 33: 107-24
2. Hasler WL. Pharmacotherapy for intestinal motor and sensory disorders. Gastroenterol Clin North Am 2003; 32: 707-32
3. Farhadi A, Bruninga K, Fields J, Keshavarzian A. Irritable bowel syndrome: an update on therapeutic modalities. Expert Opin Investig Drugs 2001; 10: 1211-22
4. Jailwala J, Imperiale TF, Kroenke K. Pharmacologic treatment of the irritable bowel syndrome: a systematic review of randomized, controlled trials. Ann Intern Med 2000; 133: 136-47
5. Pasricha PJ. Prokinetic agents, antiemetics, and agents used in irritable bowel syndrome. In: Hardman JG, Limbird LE, Goodman Gilman A, editors. Goodman & Gilman's the pharmacological basis of therapeutics New York: McGraw Hill, 2001: pp 1021-36
6. Corea G, Fattorusso E, Lanzotti V, Capasso R, Izzo A-A. Antispasmodic saponins from red onion, Allium cepa L. var. Tropea. J Agric Food Chem 2005; 53: 935-40
7. Fattorusso E, Iorizzi M, Lanzotti V, Taglialatela-Scafati O. Chemical composition of shallot (Allium ascalonicum Hort.). J Agric Food Chem 2002; 50: 5686-90
8. Amin GR. Popular Medicinal Plants of Iran. Teheran: Iranian Ministry of Health Publication, 1991: p 37
9. Mozaffarian V. A Dictionary of Iranian Plant Names. Teheran: Farhange Moaser Publication, 1996: p 29
10. Barile E, Zolfaghari B, Sajjadi S-E, Lanzotti V. Saponins of Allium elburzense. J Nat Prod 2004; 67: 2037-42
11. Gorovits M-B, Khristulas F-S, Abubakirov N-K. Alliogenin and alliogenin-β-D-glucopyranoside from Allium giganteum. Khim Prir Soedin 1971; 7: 434-42
12. Mimaki Y, Kuroda M, Sashida Y. Steroidal saponins from the bulbs of Allium aflatunense. Nat Med 1999; 53: 88-93
13. Sang S, Mao S, Lao A, Chen Z, Ho C-T. New steroid saponins from the seeds of Allium tuberosum L. Food Chem 2003; 83: 499-506
14. Izzo A-A, Borrelli F, Capasso F, Capasso R, Pinto L, Cristoni A, Mascolo N. Contractile effect of (+)-glaucine in the isolated guinea-pig ileum. Eur J Pharmacol 1999; 377: 215-8
15. Agrawal P-K, Jain DC, Gupta RK, Thakur RS. Carbon-13 NMR spectroscopy of steroidal sapogenins and steroidal saponins. Phytochemistry 1985; 24: 2479-96
16. Dong M, Feng X, Wang B, Wu L, Ikejima T. Two novel furostanol saponins from the rhizomes of Dioscorea panthaica Prain et Burkill and their cytotoxic activity. Tetrahedron 2001; 57: 501-6
17. Agrawal P-K. NMR spectroscopy in the structural elucidation of oligosaccharides and glycosides. Phytochemistry 1992; 31: 3307-3
18. Fattorusso E, Lanzotti V, Taglialatela-Scafati O. Cytotoxic saponins from bulbs of Allium porrum V. Agric Food Chem 2000; 48: 3455-62
19. Corea G, Fattorusso E, Lanzotti V. Saponins and flavonoids of Allium triguetrum. J Nat Prod 2003; 66: 1405-11
20. Kel'ginbaev A-N, Gorovits M-B, Abubakirov N-K. Steroid saponins and sapogenins of Allium. VII. Structure of neoagigenin and agigenin. Khim Prir Soedin 1974; 6: 801-2
21. Cordes E-H, Bull H-G. Mechanism and catalysis for hydrolysis of acetals, ketals, and ortho esters. Chem Rev 1974; 74: 581-603
22. Di Carlo G, Mascolo N, Izzo A-A, Capasso F. Flavonoids: Old and new aspects of a class of natural therapeutic drugs. Life Sci 1999; 65: 337-53