Antimicrobial azaphilones from the fungus Hypoxylon multiforme

Planta Medica

Volumn 71, Issue 11, 2005, Pages 1058-1062

  Quang, Dang Ngoc ^a,d   Hashimoto, Toshihiro ^a   Stadler, Marc ^b   Radulović, Niko ^c   Asakawa, Yoshinori ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b BAYER PHARMA AG   (Germany)

^c UNIVERSITY OF NI   (Serbia)

^d HANOI UNIVERSITY OF EDUCATION   (Viet Nam)

Author keywords

Antimicrobial; Azaphilone; Fungus; Hypoxylon multiforme; Multiformin

Indexed keywords

4:5:4':5' TETRAHYDROXY 1:1' BINAPHTHYL; ANTIINFECTIVE AGENT; AZAPHILONE; CHOLESTEROL ESTER TRANSFER PROTEIN; METHANOL; MULTIFORMIN A; MULTIFORMIN B; MULTIFORMIN C; MULTIFORMIN D; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTIMICROBIAL ACTIVITY; ARTICLE; ASCOMYCETES; DRUG ISOLATION; ENZYME INHIBITION; FUNGUS GROWTH; HYPOXYLON MULTIFORME; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

ANNULOHYPOXYLON MULTIFORME; ASCOMYCOTA; FUNGI; XYLARIA;

EID: 29144529122     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-873129     Document Type: Article

References (16)

1. Tabata Y, Ikegami S, Yaguchi T, Sasaki T, Hoshiko S, Sakuma S, Shin-Ya K, Seto H. Diazaphilonic acid, a new azaphilone with telomerase inhibitory activity. J Antibiot 1999; 52: 412-4
2. Tomoda H, Matsushima C, Tabata N, Namatame I, Tanaka H, Bamberger M J et al. Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones. J Antibiot 1999; 52: 160-70
3. Matsuzaki K, Tahara H, Inokoshi J, Tanaka H, Masuma R, Omura S. New brominated and halogen-less derivatives and structure-activity relationship of azaphilones inhibiting gp120-CD4 binding. J Antibiot 1998; 51: 1004-11
4. Yoshida E, Fujimoto H, Baba M, Yamazaki M. New azaphilone metabolites isolated from ascomycetous fungi, Talaromyces luteus and T. helicus. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 1993; 35: 290-7
5. Thines E, Anke H, Sterner O. Trichoflectin, a bioactive azaphilone from the ascomycete Trichopezizella nidulus. J Nat Prod 1998; 61: 306-8
6. Stadler M, Anke H, Dekermendjian K, Reiss R, Sterner O, Witt R. Novel bioactive azaphilones from fruit bodies and mycelial cultures of the Ascomycete Bulgaria inquinans (Fr.). Nat Prod Lett 1995; 7: 7-14
7. Anke H, Kemmer T, Hoefle G. Deflectins, new antimicrobial azaphilones from Aspergillus deflectus. J Antibiot 1981; 34: 923-8
8. Hashimoto T, Asakawa Y. Biologically active substances of Japanese in-edible mushrooms. Heterocycles 1998; 47: 1067-110
9. Quang DN, Hashimoto T, Nomura Y, Wollweber H, Hellwig V, Fournier J et al. Cohaerins A and B, azaphilones from the fungus Hypoxylon cohaerens, and comparison of HPLC-based metabolite profiles in Hypoxylon sect. Annulata Phytochemistry 2005; 66: 797-809
10. Quang D N, Hashimoto T, Radulović N, Fournier J, Stadler M, Asakawa Y. Sassafrins A - D, new antimicrobial azaphilones from the fungus Creosphaeria sassafras. Tetrahedron 2005; 61: 1743-8
11. Stadler M, Wollweber H, Mühlbauer A, Henkel T, Asakawa Y, Hashimoto T et al. Secondary metabolite profiles, genetic fingerprints and taxonomy of Daldinia and allies. Mycotaxon 2001; 77: 379-429
12. Takahashi M, Koyama K, Natori S. Four new azaphilones from Chaetomium globosum var. flavo-viridae. Chem Pharm Bull 1990; 38: 625-8
13. th International Supplement. Fort Wayne: Wayne Publishing, 1997: pp M2A6
14. Smith-Palmer A, Stewart J, Fyfe L. Antimicrobial properties of plant essential oils and essences against five important food-borne pathogens. Lett Appl Microbiol 1998; 26: 118-22
15. Rodriguez E, Towers GHN, Mitchell JC. Biological activities of sesquiterpene lactones. Phytochemistry 1976; 15: 1573-80
16. Stadler M, Wollweber H, Fournier J. A new species of Hypoxylon in France, and notes on the chemotaxonomy of the "Hypoxylon rubiginosum complex". Mycotaxon 2004; 90: 187-211