Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells

Pflugers Archiv European Journal of Physiology

Volumn 451, Issue 4, 2006, Pages 579-587

  Berndt, Theresa J ^a   Bielesz, Bernhard ^b   Craig, Theodore A ^a   Tebben, Peter J ^a   Bacic, Desa ^b   Wagner, Carsten A ^b   O'Brien, Stephen ^c   Schiavi, Susan ^c   Biber, Jurg ^b   Murer, Heini ^b   Kumar, Rajiv ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; PARATHYROID HORMONE; PROTEIN; SECRETED FRIZZLED RELATED PROTREIN 4; SODIUM PHOSPHATE COTRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL TRANSPORT; COMPARATIVE STUDY; CONTROLLED STUDY; IMMUNOBLOTTING; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; MALE; NONHUMAN; OPOSSUM; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; RAT; URINARY EXCRETION;

ANIMALS; CELLS, CULTURED; HUMANS; KIDNEY TUBULES, PROXIMAL; MALE; OPOSSUMS; PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE IIA;

EID: 29144490730     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-005-1495-2     Document Type: Article

References (77)

1. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 (2000) Nat Genet 26:345-348
2. i-IIa in mouse kidney and OK cells. Am J Physiol Ren Physiol 288:F740-F747
3. Berndt T, Craig TA, Bowe AE, Vassiliadis J, Reczek D, Finnegan R, Jan De Beur SM, Schiavi SC, Kumar R (2003) Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. J Clin Invest 112:785-794
4. Berndt T, Knox FG (1992) Renal regulation of phosphate excretion. Raven Press, New York
5. Biber J, Murer H (1994) A molecular view of renal Na-dependent phosphate transport. Ren Physiol Biochem 17:212-215
6. Biber J, Murer H (1993) Towards a molecular view of renal proximal tubular reabsorption of phosphate. Ren Physiol Biochem 16:37-47
7. Biber J, Stieger B, Haase W, Murer H (1981) A high yield preparation for rat kidney brush border membranes. Different behaviour of lysosomal markers. Biochim Biophys Acta 647:169-176
8. i in thyroparathyroidectomized rats. J Clin Invest 60:1419-1428
9. Bowe AE, Finnegan R, Jan de Beur SM, Cho J, Levine MA, Kumar R, Schiavi SC (2001) FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. Biochem Biophys Res Commun 284:977-981
10. Cai Q, Hodgson SF, Kao PC, Lennon VA, Klee GG, Zinsmiester AR, Kumar R (1994) Brief report: inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia. N Engl J Med 330:1645-1649
11. i cotransporters in vitamin D receptor- and 1alphaOHase-deficient mice. Am J Physiol Cell Physiol 288:C429-C434
12. Carpenter TO, Ellis BK, Insogna KL, Philbrick WM, Sterpka J, Shimkets R (2005) Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors. J Clin Endocrinol Metab 90:1012-1020
13. Chen P, Toribara T, Warner H (1956) Microdetermination of phosphorus. Anal Chem 28:1756-1758
14. Chen TC, Castillo L, Korycka-Dahl M, DeLuca HF (1974) Role of vitamin D metabolites in phosphate transport of rat intestine. J Nutr 104:1056-1060
15. Custer M, Lotscher M, Biber J, Murer H, Kaissling B (1994) Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry. Am J Physiol 266:F767-F774
16. De Beur SM, Finnegan RB, Vassiliadis J, Cook B, Barberio D, Estes S, Manavalan P, Petroziello J, Madden SL, Cho JY, Kumar R, Levine MA, Schiavi SC (2002) Tumors associated with oncogenic osteomalacia express genes important in bone and mineral metabolism. J Bone Miner Res 17:1102-1110
17. DeLuca HF (2004) Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 80:1689S-1696S
18. DeLuca HF (1980) Vitamin D: revisited 1980. Clin Endocrinol Metab 9:1-26
19. DeLuca HF, Schnoes HK (1983) Vitamin D: recent advances. Annu Rev Biochem 52:411-439
20. Econs MJ (1999) New insights into the pathogenesis of inherited phosphate wasting disorders. Bone 25:131-135
21. Econs MJ, Drezner MK (1994) Tumor-induced osteomalacia - unveiling a new hormone. N Engl J Med 330:1679-1681
22. Führ J, Kazmarczyk J, Krüttgen CD (1955) Eine einfache colorimetrische Methode zur Inulin-Bestimmung für Nierenclearance- untersuchungen bei StoffwechselGesunden und Diabetikern. Klin Wochenschr 33:729-730
23. Fukumoto S, Yamashita T (2002) Fibroblast growth factor-23 is the phosphaturic factor in tumor-induced osteomalacia and may be phosphatonin. Curr Opin Nephrol Hypertens 11:385-389
24. 3 on renal phosphate transport. Endocr Res Commun 9:135-143
25. Hattenhauer O, Traebert M, Murer H, Biber J (1999) Regulation of small intestinal Na-P(i) type IIb cotransporter by dietary phosphate intake. Am J Physiol 277:G756-G762
26. Helps C, Murer H, McGivan J (1995) Cloning, sequence analysis and expression of the cDNA encoding a sodium-dependent phosphate transporter from the bovine renal epithelial cell line NBL-1. Eur J Biochem 228:927-930
27. Hernando N, Forster IC, Biber J, Murer H (2000) Molecular characteristics of phosphate transporters and their regulation. Exp Nephrol 8:366-375
28. Hilfiker H, Hattenhauer O, Traebert M, Forster I, Murer H, Biber J (1998) Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine. Proc Natl Acad Sci USA 95:14564-14569
29. Johnson JA, Kumar R (1994) Vitamin D and renal calcium transport. Curr Opin Nephrol Hypertens 3:424-429
30. Jonsson KB, Zahradnik R, Larsson T, White KE, Sugimoto T, Imanishi Y, Yamamoto T, Hampson G, Koshiyama H, Ljunggren O, Oba K, Yang IM, Miyauchi A, Econs MJ, Lavigne J, Juppner H (2003) Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N Engl J Med 348:1656-1663
31. i cotransporter. Proc Natl Acad Sci USA 97:12896-12901
32. Kaufmann M, Muff R, Stieger B, Biber J, Murer H, Fischer JA (1994) Apical and basolateral parathyroid hormone receptors in rat renal cortical membranes. Endocrinology 134:1173-1178
33. Kempson SA, Lotscher M, Kaissling B, Biber J, Murer H, Levi M (1995) Parathyroid hormone action on phosphate transporter mRNA and protein in rat renal proximal tubules. Am J Physiol 268:F784-F791
34. i-cotransporter type II. Kidney Int 54:1224-1232
35. Kozak SL, Kabat D (1990) Ping-pong amplification of a retroviral vector achieves high-level gene expression: human growth hormone production. J Virol 64:3500-3508
36. Kumar R (1980) The metabolism of 1,25-dihydroxyvitamin D3. Endocr Rev 1:258-267
37. Kumar R (2002) New insights into phosphate homeostasis: fibroblast growth factor 23 and frizzled-related protein-4 are phosphaturic factors derived from tumors associated with osteomalacia. Curr Opin Nephrol Hypertens 11:547-553
38. Kumar R (1997) Phosphatonin - a new phosphaturetic hormone? (lessons from tumour-induced osteomalacia and X-linked hypophosphataemia). Nephrol Dial Transplant 12:11-13
39. Kumar R (2000) Tumor-induced osteomalacia and the regulation of phosphate homeostasis. Bone 27:333-338
40. Kumar R, Haugen JD, Wieben ED, Londowski JM, Cai Q (1995) Inhibitors of renal epithelial phosphate transport in tumor-induced osteomalacia and uremia. Proc Assoc Am Physicians 107:296-305
41. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
42. Larsson T, Marsell R, Schipani E, Ohlsson C, Ljunggren O, Tenenhouse HS, Juppner H, Jonsson KB (2004) Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 145:3087-3094
43. Levi M, Kempson SA, Lotscher M, Biber J, Murer H (1996) Molecular regulation of renal phosphate transport. J Membr Biol 154:1-9
44. i-cotransporter by parathyroid hormone: immunohistochemistry. Kidney Int 49:1010-1011
45. i cotransport. Proc Natl Acad Sci USA 90:5979-5983
46. i reabsorption: some answers and more questions. J Am Soc Nephrol 2:1649-1665
47. Murer H, Biber J (1995) Molecular mechanisms in renal phosphate reabsorption. Nephrol Dial Transplant 10:1501-1504
48. Murer H, Biber J (1994) Renal sodium-phosphate cotransport. Curr Opin Nephrol Hypertens 3:504-510
49. Murer H, Biber J (1993) Structural identification of brush border membrane transport systems - towards an understanding of regulatory mechanisms. Clin Invest 71:852-854
50. Murer H, Evers C, Stoll R, Kinne R (1977) The effect of parathyroid hormone (PTH) and dietary phosphate on the sodium-dependent phosphate transport system located in the rat renal brush border membrane. Curr Probl Clin Biochem 8:455-462
51. Murer H, Hernando N, Forster I, Biber J (2001) Molecular aspects in the regulation of renal inorganic phosphate reabsorption: the type IIa sodium/inorganic phosphate co-transporter as the key player. Curr Opin Nephrol Hypertens 10:555-561
52. Murer H, Hernando N, Forster L, Biber J (2001) Molecular mechanisms in proximal tubular and small intestinal phosphate reabsorption (plenary lecture). Mol Membr Biol 18:3-11
53. i cotransporter: structure-function relationships. Cell Biochem Biophys 36:215-220
54. i-cotransport: molecular aspects in PTH-dependent and dietary regulation. Kidney Int 49:1769-1773
55. i medium. Pflugers Arch 435:713-719
56. i cotransporter. Proc Natl Acad Sci USA 95:1909-1914
57. Puschett JB, Fernandez PC, Boyle IT, Gray RW, Omdahl JL, DeLuca HF (1972) The acute renal tubular effects of 1,25-dihydroxycholecalciferol. Proc Soc Exp Biol Med 141:379-384
58. Puschett JB, Kuhrman MS (1978) Renal tubular effects of 1,25-dihydroxy vitamin D3: interactions with vasopressin and parathyroid hormone in the vitamin D-depleted rat. J Lab Clin Med 92:895-903
59. Radanovic T, Wagner CA, Murer H, Biber J (2005) Regulation of intestinal phosphate transport. I. Segmental expression and adaptation to low-P(i) diet of the type IIb Na(+)-P(i) cotransporter in mouse small intestine. Am J Physiol Gastrointest Liver Physiol 288:G496-G500
60. Riminucci M, Collins MT, Fedarko NS, Cherman N, Corsi A, White KE, Waguespack S, Gupta A, Hannon T, Econs MJ, Bianco P, Gehron Robey P (2003) FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. J Clin Invest 112:683-692
61. Rizzoli R, Fleisch H, Bonjour JP (1977) Role of 1,25-dihydroxyvitamin D3 on intestinal phosphate absorption in rats with a normal vitamin D supply. J Clin Invest 60:639-647
62. Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (2000) MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Genomics 67:54-68
63. Rowe PS, Kumagai Y, Gutierrez G, Garrett IR, Blacher R, Rosen D, Cundy J, Navvab S, Chen D, Drezner MK, Quarles LD, Mundy GR (2004) MEPE has the properties of an osteoblastic phosphatonin and minhibin. Bone 34:303-319
64. Schiavi SC, Kumar R (2004) The phosphatonin pathway: new insights in phosphate homeostasis. Kidney Int 65:1-14
65. Segawa H, Kaneko I, Yamanaka S, Ito M, Kuwahata M, Inoue Y, Kato S, Miyamoto K (2004) Intestinal Na-P(i) cotransporter adaptation to dietary P(i) content in vitamin D receptor null mice. Am J Physiol Ren Physiol 287:F39-F47
66. Shimada T, Urakawa I, Yamazaki Y, Hasegawa H, Hino R, Yoneya T, Takeuchi Y, Fujita T, Fukumoto S, Yamashita T (2004) FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa. Biochem Biophys Res Commun 314:409-414
67. Sitara D, Razzaque MS, Hesse M, Yoganathan S, Taguchi T, Erben RG, H JA-P, Lanske B (2004) Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol 23:421-432
68. i-IIb in small intestine. Am J Physiol Gastrointest Liver Physiol 288:G501-G506
69. 3. Am J Physiol 229:489-495
70. Stoll R, Kinne R, Murer H (1979) Effect of dietary phosphate intake on phosphate transport by isolated rat renal brush-border vesicles. Biochem J 180:465-470
71. Tanaka Y, Deluca HF (1973) The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus. Arch Biochem Biophys 154:566-574
72. Towbin H, Staehelin T, Gordon J (1992) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications, 1979. Biotechnology 24:145-149
73. Traebert M, Roth J, Biber J, Murer H, Kaissling B (2000) Internalization of proximal tubular type II Na-P(i) cotransporter by PTH: immunogold electron microscopy. Am J Physiol Ren Physiol 278:F148-F154
74. i cotransporter, which is regulated by dietary phosphate. Am J Physiol 268:F626-F633
75. i diet in rat kidney cortex. J Biol Chem 269:6637-6639
76. i cotransport system of kidney cortex. Proc Natl Acad Sci USA 88:9608-9612
77. i cotransport system from flounder. Am J Physiol 267:F311-F317