Higher median levels of free β-hCG and PAPP-A in the first trimester of pregnancy in a Chinese Ethnic Group: Implication for first trimester combined screening for Down's syndrome in the Chinese population

Fetal Diagnosis and Therapy

Volumn 21, Issue 1, 2005, Pages 140-143

  Tak, Yeung Leung ^a   Spencer, Kevin ^b   Tse, Ngong Leung ^a   Tak, Yuen Fung ^a   Tze, Kin Lau ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b HAROLD WOOD HOSPITAL   (United Kingdom)

Author keywords

Biochemical markers; Chinese; First trimester; Screening; Trisomy 21

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; PREGNANCY ASSOCIATED PLASMA PROTEIN A;

ADULT; ALGORITHM; ARTICLE; BODY WEIGHT; CALCULATION; CAUCASIAN; CHINESE; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN SYNDROME; ETHNOLOGY; FEMALE; FETUS; FIRST TRIMESTER PREGNANCY; HUMAN; PRENATAL SCREENING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK ASSESSMENT;

BIOLOGICAL MARKERS; CHINA; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; DOWN SYNDROME; FEMALE; HUMANS; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PRENATAL DIAGNOSIS;

EID: 29144475399     PISSN: 10153837     EISSN: None     Source Type: Journal    
DOI: 10.1159/000089064     Document Type: Article

References (13)

1. Spencer K, Macri JN, Aithen DA, Connor JM: Free β-hCG as first trimester marker for fetal trisomy Lancet 1992;339:1480.
2. Brambati B, Macintosh MC, Teisner B, Maguiness S, Shrimanker K, Lanzani A, Bonacchi I, Tului L, Chard T, Grudzinskas JG: Low maternal serum levels of pregnancy associated plasma protein A (PAPP-A) in the first trimester in association with abnormal fetal karyotype. Br J Obstet Gynaecol 1993;100:324-326.
3. Snijders RJ, Noble P, Sebire N, Souka A, Nicolaides KH: UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation. Fetal Medicine Foundation First Trimester Screening Group. Lancet 1998;352:343-346.
4. Spencer K, Spencer CE, Power M, Dawson C, Nicolaides KH: Screening for chromosomal abnormalities in the first trimester using ultrasound and maternal serum biochemistry in a one-stop clinic: A review of three years prospective experience. BJOG 2003;110:281-286.
5. Thilaganathan B, Khare M, Williams B, Wathen NC: Influence of ethnic origin on nuchal translucency screening for Down's syndrome. Ultrasound Obstet Gynecol 1998;12:112-114.
6. Benn PA, Clive JM, Collins R: Medians for second-trimester maternal serum alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol: Differences between races or ethnic groups. Clin Chem 1997;43:333-337.
7. O'Brien JE, Dvorin E, Drugan A, Johnson MP, Yaron Y, Evans MI: Race-ethnicity-specific variation in multiple-marker biochemical screening: α-Fetoprotein, hCG, and estriol. Obstet Gynecol 1997;89:355-358.
8. Bryant-Greenwood PK, O'Brien JE, Huang X, Yaron Y, Ayoub M, Johnson MP, Evans MI: Maternal weight differences do not explain ethnic differences in biochemical screening. Fetal Diagn Ther 1998;13:46-48.
9. Brooks K, Chik L, O'Brien JE, Ayoub M, Johnson MP, Evans MI: Variability of adjustments to indices in determining patient risk in biochemical screening. Fetal Diagn Ther 1999;14:41-46.
10. Hsieh TT, Hsu JJ, Chen CP, Tsai MS, Hsieh FJ, Hu A, Spencer K: Down's syndrome screening with AFP and free β-hCG: An analysis of the influence of Chinese ethnic origin on screening parameters. Am J Hum Genet 1995;57:1632.
11. Spencer K, Souter V, Tul N, Snijders R, Nicolaides KH: A screening program for trisomy 21 at 10-14 weeks using fetal nuchal translucency, maternal serum free β-human chorionic gonadotropin and pregnancy associated plasma protein-A. Ultrasound Obstet Gynecol 1999;13:231-237.
12. Neveux LM, Palomaki GE, Larrivee DA, Knight GJ, Haddow JE: Refinements in managing maternal weight adjustment for interpreting prenatal screening results. Prenat Diagn 1996;16:1115-1119.
13. Spencer K, Ong CY, Liao AW, Nicolaides KH: The influence of ethnic origin on first trimester biochemical markers of chromosomal abnormalities. Prenat Diagn 2000;20:491-494.