Mega dose of vitamin C augments the nephrotoxicity of paracetamol

Nephrology

Volumn 10, Issue 6, 2005, Pages 623-624

  Abraham, Premila ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CREATININE; DEFEROXAMINE; GLUTATHIONE; IRON CHELATING AGENT; LIPID PEROXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PARACETAMOL; SCAVENGER; TRANSITION ELEMENT;

CREATININE BLOOD LEVEL; DNA DAMAGE; DOSE RESPONSE; DRUG HYDROXYLATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENTIATION; DRUG TOLERANCE; HUMAN; IN VIVO STUDY; KIDNEY FAILURE; KIDNEY INJURY; LETTER; LIPID PEROXIDATION; LIVER CELL; LIVER NECROSIS; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; DRUG INTERACTIONS; KIDNEY DISEASES; MALE; RATS; RATS, WISTAR;

EID: 29144463545     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2005.00477.x     Document Type: Letter

References (24)

1. O'Grady JG. Paracetamol-induced acute liver failure: Prevention and management. J. Hepatol. 1997; 26: 41-6.
2. Eguia L, Materson BJ. Acetaminophen related acute renal failure without fulminant liver failure. Pharmacotherapy 1997; 17: 363-70.
3. Moller-Hartmann W, Seigers CP. Nephrotoxicity of paracetamol in the rat. Mechanistic and therapeutic aspects. J. Appl. Toxicol. 1992; 11: 141-6.
4. Jaya DS, Augstine J, Menon VP. Role of lipid peroxides, glutathione and antiperoxidative enzymes in alcohol and drug toxicity. Indian J. Exp Biol. 1993; 31: 453-9.
5. Engelhardt G, Hopmma D. Effects of acetyl salicylic acid, paracetamol and caffeine and a combination of these substances on kidney glutathione levels. Arzneimittelforschung 1996; 46: 513-18.
6. Niki E. Action of ascorbic acid as a scavenger of active and stable oxygen radicals. Am. Clin. Nutr 1991; 54: 1119S-1124S.
7. Doba T, Burton GW, Ingold KU. Antioxidant and co-oxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes. Biochim. Biophys. Acta 1985; 835: 298-303.
8. Peterson FJ, Knodell RG. Ascorbic acid protects against acetaminophen and cocaine -induced hepatic damage in mice. Drug Nutr Interact 1984; 3: 33-41.
9. Abraham P. Oxidative stress in paracetamol-induced pathogenesis: I. Renal damage. Indian J. Biochem. Biophys. 2005; 42: 59-62.
10. Martensson J, Meister A. Glutathione deficiency increases hepatic ascorbic acid synthesis in adult mice. Proc. Natl Acad. Sci. USA 1992; 89: 11 566-8.
11. Meister A. Glutathione-ascorbic acid anti-oxidant system in animals. J. Biol. Chem. 1994; 269: 9397-400.
12. Puskas F, Gergely P Jr, Banki K, Perl A. Stimulation of pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C. FASEB J. 2000; 14: 1352-61.
13. Kim EJ, Park YG, Baik EJ et al. Dehydroascorbic acid prevents oxidative cell death through a glutathione pathway in primary astrocytes. J. Neurosci. Res. 2005; 79: 670-79.
14. Sadrzadeh SMH, Eaton JW. Hemoglobin mediated oxidant damage to the central nervous system requires endogenous ascorbate. J. Clin. Invest 1988; 82: 1510-15.
15. Podmore ID, Griffith HR, Herbert KE, Mistry N, Mistry P, Lunec J. Vitamin C exhibits pro-oxidant properties. Nature 1998; 392: 559.
16. Song Jh, Shin Sh, Wang W, Ross GM. Involvement of oxidative stress in ascorbate- induced proapoptotic death of PC12 cells. Exp Neurol. 2001; 169: 425-37.
17. Song JH, Simons C, Cao L, Shin SH, Hong M, Chung IM. Rapid uptake of oxidized ascorbate induces loss of cellular glutathione and oxidative stress in liver slices. Exp Mol Med. 2003; 35: 67-75.
18. Carr A, Frei B. Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J. 1999; 13: 1007-24.
19. Halliwell B. Vitamin C: antioxidant or pro-oxidant in vivo? Free Radic Res. 1996; 25: 439-54.
20. Gutteridge JMC. Iron promoters of the Fenton reaction and lipid peroxidation can be released from hemoglobin by peroxides. FEBS Lett. 1986; 201: 291-5.
21. Aust SD, Chignell CF, Bray TM et al. Free radicals in toxicology. Toxicol. Appl. Pharmacol. 1993; 120: 168-78.
22. Ito Y, Suzuki Y, Ogonuki H et al. Role of iron and glutathione redox cycle in acetaminophen-induced cytotoxicity to cultured rat hepatocytes. Dig. Dis. Sci. 1994; 39: 1257-64.
23. Sakaida I, Kayano K, Wasaki S, Nagatomi A, Matsumura Y, Okita K. Protection against acetaminophen-induced liver injury in vivo by an iron chelator, deferoxamine. Scand. J. Gastroenterol. 1995; 30: 61-7.
24. Bauer I, Vollimar B, Jaesehke H et al. Transcriptional activation of Heme oxygenase-1 and its functional significance in acetaminophen-induced hepatitis and hepatocellular injury in the rat. J. Hepatol. 2000; 33: 395-406.