Hepatoprotective bile acid 'ursodeoxycholic acid (UDCA)': Property and difference as bile acids

Hepatology Research

Volumn 33, Issue 2, 2005, Pages 174-177

  Ishizaki, Kaoru ^a   Imada, Teruaki ^a   Tsurufuji, Makoto ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Bile acids; Hepatoprotection; Ursodeoxycholic acid (UDCA)

Indexed keywords

BILE ACID; CHINESE DRUG; CHOLERETIC AGENT; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; YUTAN;

BEAR; BILE ACID SYNTHESIS; CHOLELITHIASIS; CYTOTOXICITY; DRUG ACTIVITY; DRUG APPROVAL; DRUG EFFICACY; DRUG METABOLISM; FOOD AND DRUG ADMINISTRATION; HUMAN; IN VITRO STUDY; JAPAN; LIVER DISEASE; LIVER PROTECTION; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 29144453310     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hepres.2005.09.029     Document Type: Article

References (10)

1. D.M. Heuman Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions J Lipid Res 30 1989 719-730
2. C.M.P. Rodrigues G. Fan X. Ma B.T. Kren C.J. Steer A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation J Clin Invest 101 1998 2790-2799
3. G. Toda N. Tanaka Y. Ikeda et al. The long-term trial of ursodeoxycholic acid treatment in patients with primary biliary cirrhosis Igaku to yakugaku 41 1999 609-633
4. J. Shoda M. Kano K. Oda et al. The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function Am J Gastroenterol 96 2001 3368-3378
5. D. Rost T. Herrmann P. Sauer et al. Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: Effect of ursodeoxycholate Hepatology 38 2003 187-195
6. M. Trauner M. Arrese C.J. Soroka et al. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis Gastroenterology 113 1997 255-264
7. P. Fickert G. Zollner A. Fuchsbichler et al. Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver Gastroenterology 121 2001 170-183
8. S. Sakisaka T. Kawaguchi E. Taniguchi et al. Alterations in tight junctions differ between primary biliary cirrhosis and primary sclerosing cholangitis Hepatology 33 2001 1460-1468
9. A. Crosignani M. Podda P.M. Battezzati et al. Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration Hepatology 14 1991 1000-1007
10. R.E. Poupon K.D. Lindor K. Cauch-Dudek E.R. Dickson R. Poupon E.J. Heathcote Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis Gastroenterology 113 1997 884-890