Free and bound enantiomers of methadone and its metabolite, EDDP in methadone maintenance treatment: Relationship to dosage?

Clinical Biochemistry

Volumn 38, Issue 12, 2005, Pages 1088-1094

  Lehotay, D C ^a,c   George, S ^a   Etter, M L ^a   Graybiel, K ^a   Eichhorst, J C ^a   Fern, B ^e   Wildenboer, W ^f   Selby, P ^d   Kapur, B ^b  

^a Provincial Laboratory   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e Regina Community Clinic ^*  (Canada)

^f Regina Cancer Centre   (Canada)

Author keywords

Bound; Dosage; EDDP; Enantiomer; Free; LC MS MS; Methadone; Tandem MS; Withdrawal symptoms

Indexed keywords

2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; DRUG METABOLITE; METHADONE; PYRROLIDINE DERIVATIVE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CHIRAL CHROMATOGRAPHY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG ISOLATION; DRUG MEGADOSE; DRUG METABOLISM; DRUG PROTEIN BINDING; ENANTIOMER; EVAPORATION; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; LOW DRUG DOSE; MASS SPECTROMETRY; MOLECULAR WEIGHT; PRIORITY JOURNAL; ULTRAFILTRATION;

BLOOD PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; METHADONE; MOLECULAR WEIGHT; PROTEIN BINDING; PYRROLIDINES; STEREOISOMERISM; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS;

EID: 29144442134     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2005.09.009     Document Type: Article

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