NCA nucleophilic radiofluorination on substituted benzaldehydes for the preparation of [18F]fluorinated aromatic amino acids

Applied Radiation and Isotopes

Volumn 64, Issue 3, 2006, Pages 355-359

  Wadsak, Wolfgang ^a   Wirl Sagadin, Barbara ^a,b   Mitterhauser, Markus ^a,b,c   Mien, Leonhard Key ^a,b   Ettlinger, Dagmar E ^a   Keppler, Bernhard K ^b   Dudczak, Robert ^a   Kletter, Kurt ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

Fluorine 18; Nucleophilic aromatic substitution; PET

Indexed keywords

AMINO ACIDS; CARBOXYLIC ACIDS; OPTIMIZATION; POSITRON EMISSION TOMOGRAPHY; PURIFICATION;

AROMATIC AMINO ACIDS; FLUORINE-18; NUCLEOPHILIC AROMATIC SUBSTITUTION; RADIOFLUORINATION;

ALDEHYDES;

AROMATIC AMINO ACID; BENZALDEHYDE; FLUORINE 18;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION KINETICS; FLUORINATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTUM YIELD; RADIOCHEMISTRY; REACTION OPTIMIZATION; SOLID PHASE EXTRACTION; SUBSTITUTION REACTION;

AMINO ACIDS, AROMATIC; BENZALDEHYDES; FLUORINE RADIOISOTOPES; HYDROCARBONS, AROMATIC; ISOTOPE LABELING; RADIOPHARMACEUTICALS;

EID: 29144438849     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2005.09.001     Document Type: Article

References (16)

1. J.R. Barrio, S.C. Huang, and M.E. Phelps Biological imaging and the molecular basis of dopaminergic diseases Biochem. Pharmacol. 54 1997 341 348
2. A. Becherer, M. Szabo, G. Karanikas, P. Wunderbaldinger, P. Angelberger, M. Raderer, A. Kurtaran, R. Dudczak, and K. Kletter Imaging of advanced neuroendocrine tumors with (18)F-FDOPA PET J. Nucl. Med. 45 7 2004 1161 1167
3. 18F]fluoro-Image-DOPA Appl. Radiat. Isot. 51 1999 389 394
4. 18F]levodopa postitron emission tomography in patients with Parkinson′s disease Clin. Pharmacol. Therapeutics 70 2001 33 41
5. 18F]fluorides via the nucleophilic aromatic substitution of electron aromatic rings J. Fluorine Chem. 48 1990 189 205
6. 18F-FDOPA positron emission tomography for tumor detection in patients with medullary thyroid carcinoma and elevated calcitonin levels Eur. J. Nucl. Med. 28 2001 64 71
7. 18F]fluoro-L-dopa with β-tyrosinase Appl. Rad. Isot. 50 1999 1025 1032
8. 18F- fluorinated α-amino acids under phase-transfer conditions using (S)-NOBIN Nucl. Med. Biol. 31 2004 597 603
9. P. Laverman, O.C. Boerman, F.H.M. Corstens, and J.G.W. Oyen Fluorinated amino Acids for tumor imaging with positron emission tomography Eur. J. Nucl. 29 2002 681 690
10. 18F]-fluoro-L-dopa J. Nucl. Med. 31 1990 1247 1251
11. 18F]fluorodopa via nucleophilic fluorination Appl. Radiat. Isot. 42 1991 629 635
12. 18F]-fluoro-L-dopa. via two chiral auxiliaries Appl. Radiat. Isot. 44 1993 737 744
13. C. Lemaire, P. Damhaut, A. Pleneveaux, and D. Comar Enantioselective synthesis of 6-[Fluorine-18]-Fluoro-L-Dopa from No-Carrier-Added Fluorine.18-Fluoride J. Nucl. Med. 35 12 1994 1996 2002
14. 18F]-fluoro-L-dopa and its metabolism in vivo- a critical review Appl. Radiat. Isot. 19 1992 149 158
15. 18F]-fluoro-L-dopa and its remote routine preparation for PET investigations of dopaminergic systems Appl. Radiat. Isot. 44 1993 645 649
16. 18F]fluoro-L-DOPA Appl. Rad. Isot. 57 2002 145 151