A multicenter phase II study of "adjuvant" irinotecan following resection of colorectal hepatic metastases

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 28, Issue 6, 2005, Pages 547-554

  Mackay, Helen J ^a   Billingsley, Kevin ^b   Gallinger, Steven ^c   Berry, Scott ^d   Smith, Andrew ^d   Yeung, Raymond ^b   Pond, Gregory R ^a   Croitoru, Marina ^c   Swanson, Paul E ^b   Krishnamurthi, Smitha ^e   Siu, Lillian L ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF WASHINGTON   (United States)

^c MOUNT SINAI HOSPITAL   (Canada)

^d WOMEN S COLLEGE HOSPITAL   (Canada)

^e CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Chemotherapy; Hepatic colorectal metastases; Irinotecan (CPT 11); Liver resection; Microsatellite instability; p27; p53

Indexed keywords

FLUOROURACIL; IRINOTECAN; PROTEIN P27; PROTEIN P53;

ADULT; AGED; ARTICLE; BLOOD TOXICITY; CANCER ADJUVANT THERAPY; CANCER RELAPSE; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; CONFIDENCE INTERVAL; DEHYDRATION; DIARRHEA; DRUG TOLERABILITY; FEBRILE NEUTROPENIA; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; LIVER RESECTION; MALE; MICROSATELLITE INSTABILITY; MULTICENTER STUDY; NAUSEA; PHASE 2 CLINICAL TRIAL; SEPSIS; VOMITING;

ADENOCARCINOMA; ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CHEMOTHERAPY, ADJUVANT; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE-FREE SURVIVAL; DNA, NEOPLASM; FEMALE; FLUOROURACIL; GASTROINTESTINAL DISEASES; HEPATECTOMY; HUMANS; LIFE TABLES; LIVER NEOPLASMS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; NEOPLASM PROTEINS; NEUTROPENIA; SURVIVAL ANALYSIS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 29044446222     PISSN: 02773732     EISSN: 1537453X     Source Type: Journal    
DOI: 10.1097/01.coc.0000178031.69209.47     Document Type: Article

References (24)

1. Canadian Cancer Society/National Cancer Institute of Canada. Canadian Cancer Statistics 2005. Toronto, Canada, 2004.
2. August DA, Sugarbaker PH, Ottow RT, et al. Hepatic resection of colorectal metastases: influence of clinical factors and adjuvant intraperitoneal 5-fluorouracil via Tenchkoff catheter on survival. Ann Surg. 1985;201:210-218.
3. Hughes KS, Simon R, Songhorabodi S, et al. Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of patterns of recurrence. Surgery. 1986;100:278-284.
4. Fong Y, Cohen AM, Fortner JG, et al. Liver resection for colorectal metastases. J Clin Oncol. 1997;15:938-946.
5. Iwatsuki S, Esquival C, Gordon R, et al. Liver resection for metastatic colorectal cancer. Surgery, 1986;100:804-810.
6. Fortner JG, Silva JS, Golbey RB, et al. Multivariate analysis of a personal series of 247 consecutive patients with liver metastases from colorectal cancer. I. Treatment by hepatic resection. Ann Surg. 1984;199:306-316.
7. Kemeny MM, Adak S, Gray B, et al. Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy-an intergroup study. J Clin Oncol. 2002;20:1499-1505.
8. Kemeny N, Huang Y, Cohen AM, et al. Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med. 1999;341:2039-2048.
9. Shimada Y, Yoshino M, Wakui A, et al. Phase II study of CPT11, a new camptothecin derivative in metastatic colorectal cancer. J Clin Oncol. 1993;11:909-913.
10. Rougier P, Bugat R, Douillard JY, et al. Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pre-treated with fluorouracil-based chemotherapy. J Clin Oncol. 1997;15:251-260.
11. Rougier P, Van Cutsem E, Bajetta E, et al. Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet. 1998;352:1407-1412.
12. Cunningham D, Pryhonen S, James RD, et al. Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet. 1998;352:1413-1418.
13. Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998;58:5248-5257.
14. Gryfe R, Kim H, Hseih ETK, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med. 2000;342:69-77.
15. McLeod HI, Murray GI. Tumor markers of prognosis in colorectal cancer. Br J Cancer. 1999;79:191-203.
16. Watanabe T, Wu TT, Catalano PJ, et al. Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med. 2001;344:1196-1206.
17. Ribic C, Sargent DJ, Moore MJ, et al. Tumor microsatellite status as a predictor of benefit from fluorouracil based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003;349:247-257.
18. Ahnen DJ, Feigl P, Quan G, et al. Ki-Ras mutation and p53 expression predict the clinical behaviour of colorectal cancer: a South West Oncology Group Study. Cancer Res. 1998;58:1149-1158.
19. Liu DF, Ferguson K, Cooper GS, et al. P27 cell-cycle inhibitor is inversely correlated with lymph node metastases in right-sided colon cancer. J Clin Lab Anal. 1999;13:291-295.
20. Hughes K, Scheele J, Sugarbaker P. Surgery for colorectal cancer metastatic to the liver: optimizing the results of treatment. Surg Clin North Am. 1989;69:339-359.
21. Lorenz M, Muller HH, Staib-Sebler E, et al. Relevance of neoadjuvant and adjuvant treatment for patients with resectable liver metastases of colorectal carcinoma. Langenbeck Arch Surg. 1999;384:328-338.
22. Kemeny N, Jamagin W, Gonen M, et al. Phase I/II study of hepatic arterial therapy with floxuridine and dexamethasone in combination with intravenous irinotecan as adjuvant treatment after resection of hepatic metastases from colorectal cancer. J Clin Oncol 2003;21:3303-3309.
23. Saltz LB, Cox JV, Blanke C, et al. Irinotecan fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med. 2000;343:905-914.
24. De Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first line treatment in advanced colorectal cancer. J Clin Oncol. 2000;18:2938-2947.