Neonicotinoid metabolic activation and inactivation established with coupled nicotinic receptor-CYP3A4 and -aldehyde oxidase systems

Toxicology Letters

Volumn 161, Issue 2, 2006, Pages 108-114

  Honda, Hideo ^a,b   Tomizawa, Motohiro ^a   Casida, John E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MITSUI CHEMICALS INC   (Japan)

Author keywords

Aldehyde oxidase; CYP3A4; Metabolism; Neonicotinoid; Nicotinic receptor

Indexed keywords

ALDEHYDE OXIDASE; ANABASINE; CHOLINERGIC RECEPTOR; CLOTHIANIDIN; CYTOCHROME P450 3A4; DESMETHYL THIAMETHOXAM; DINOTEFURAN; IMIDACLOPRID; INSECTICIDE; KETOCONAZOLE; MENADIONE; N METHYLNICOTINAMIDE; NICOTINE; NICOTINIC RECEPTOR; NITENPYRAM; NITHIAZINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIAMETHOXAM; TRITIUM; UNCLASSIFIED DRUG; CYTOCHROME B5; CYTOCHROME P450; DRUG DERIVATIVE;

ARTICLE; ASSAY; DROSOPHILA; INCUBATION TIME; INTOXICATION; METABOLIC ACTIVATION; METABOLISM; PRIORITY JOURNAL; RECEPTOR BINDING; ANIMAL; CHEMICAL MODEL; CHEMICAL STRUCTURE; DRUG DELIVERY SYSTEM; DRUG DESIGN; ENZYME ACTIVATION; MOUSE;

INSECTA; VERTEBRATA;

ALDEHYDE OXIDASE; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES B5; DROSOPHILA; DRUG DELIVERY SYSTEMS; DRUG DESIGN; ENZYME ACTIVATION; MICE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NICOTINE; RECEPTORS, NICOTINIC;

EID: 29044440259     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.08.004     Document Type: Article

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