The higher toxicity of cereulide relative to valinomycin is due to its higher affinity for potassium at physiological plasma concentration

Toxicology and Applied Pharmacology

Volumn 210, Issue 1-2, 2006, Pages 39-46

  Teplova, Vera V ^a,b   Mikkola, Raimo ^a   Tonshin, Anton A ^a,c   Saris, Nils Erik L ^a   Salkinoja Salonen, Mirja S ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b INSTITUTE OF THEORETICAL AND EXPERIMENTAL BIOPHYSICS   (Russian Federation)

^c MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Cereulide; Membrane potential; Mitochondria; Oxidative phosphorylation; Potassium; Respiratory chain; Swelling; Uncoupling; Valinomycin

Indexed keywords

BACTERIAL TOXIN; CEREULIDE; CYTOCHROME C OXIDASE; IONOPHORE; POTASSIUM; POTASSIUM CHLORIDE; POTASSIUM ION; UNCLASSIFIED DRUG; VALINOMYCIN;

ANIMAL MODEL; ARTICLE; BIOACCUMULATION; BLOOD LEVEL; CELL MEMBRANE TRANSPORT; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TOXICITY; MITOCHONDRION SWELLING; NONHUMAN; POTASSIUM TRANSPORT; RAT; RESPIRATORY CHAIN; SERUM; TOXICITY;

ANIMALS; BACTERIAL TOXINS; DEPSIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT; IONOPHORES; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; MOLECULAR STRUCTURE; OXYGEN CONSUMPTION; POTASSIUM CHANNELS; POTASSIUM CHLORIDE; RATS; RATS, WISTAR; VALINOMYCIN;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 29044434815     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.06.012     Document Type: Article

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