A scalable synthesis of L-leucine-N-carboxyanhydride

Organic Process Research and Development

Volumn 9, Issue 6, 2005, Pages 757-763

  Smeets, N M B ^a   Van Der Weide, P L J ^a   Meuldijk, J ^a   Vekemans, J A J M ^a   Hulshof, L A ^a  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

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EID: 28944437192     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op058009e     Document Type: Article

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34. allproducts. The scaled-up leucine-NCA synthesis in the presence of (+)-limonene has an AE of 43%; this in contrast to the AE of 28% of the original procedure depicted in Scheme 1.
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39. The reactants used for these experiments were not of the same standard when compared to the laboratory experiments. Both toluene and THF were not freshly distilled, and L-leucine was not dried in advance.