Is there an answer? What is the biological significance of the brain-specific tubulin-polymerization promoting protein (TPPP/p25)?

IUBMB Life

Volumn 57, Issue 11, 2005, Pages 765-768

  Ovádi, Judit ^a   Orosz, Ferenc ^a   Lebotzky, Attila ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN P25; TUBULIN POLYMERIZATION PROMOTING PROTEIN; UNCLASSIFIED DRUG; NERVE PROTEIN; P25 PROTEIN, HUMAN;

BRAIN; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; REVIEW; STATISTICAL SIGNIFICANCE; ARTICLE; GENETICS; HELA CELL; PHYSIOLOGY;

BRAIN; HELA CELLS; HUMANS; NERVE TISSUE PROTEINS;

EID: 28844493169     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1080/15216540500381101     Document Type: Review

References (25)

1. Kopito, R. R. (2000) Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol. 10, 524-530.
2. Orosz, F., Kovács, G. G., Lehotzky, A., Oláh, J., Vincze, O., and Ovádi, J. (2004) TPPP/p25: from unfolded protein to misfolding disease. Prediction and experiments. Biol. Cell. 96, 701-711.
3. Dunker, A. K., Brown, C. J., Lawson, J. D., Iakoucheva, L. M., and Obradovic, Z. (2002) Intrinsic disorder and protein function. Biochemistry 41, 6573-6582.
4. Wright, P. E., and Dyson, H. J. (1999) Intrinsically unstructured proteins: Re-assessing the protein structure-function paradigm. J. Mol. Biol. 293, 321-331.
5. Johnston, J. A., Ward, C. L., and Kopito, R. R. (1998) Aggresomes: A cellular response to misfolded proteins. J. Cell Biol. 143, 1883-1898.
6. Liliom, K., Wágner, G., Kovács, J., Comin, B., Cascante, M., Orosz, F., and Ovádi, J. (1999) Combined enhancement of microtubule assembly and glucose metabolism in neuronal systems in vitro. Decreased sensitivity to copper toxicity. Biochem. Biophys. Res. Commun. 264, 605-610.
7. Hlavanda, E., Kovács, J., Oláh, J., Orosz, F., Medzihradszky, K. F., and Ovádi, J. (2002) Brain-specific p25 protein binds to tubulin and microtubule and induces aberrant microtubule assemblies at substoichiometric concentration. Biochemistry 41, 8657-8664.
8. Takahashi, M., Tomizawa, K., Ishiguro, K., Sato, K., Omori, A., Sato, S., Shiratsuchi, A., Uchida, T., and Imahori, K., (1991) A novel brain-specific 25 kDa protein (p25) is phosphorylated by a Ser/Thr-Pro kinase (TPK II) from tau protein kinase fractions. FEBS Lett. 289, 37-43.
9. Shiratsuchi, A., Sato, S., Oomori, A., Ishiguro, K., Uchida, T., and Imahori, K. (1995) cDNA cloning of a novel brain-specific protein p25. Biochem. Biophys. Acta 1251, 66-68.
10. Seki, N., Hattori, A., Sugano, S., Suzuki, Y., Nakagawara, A., Muramatsu, M., Hori, T., and Saito, T. (1999) A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3. J. Hum. Genet. 44, 121-122.
11. Martin, C. P., Vazquez, J., Avila, J., and Moreno, F. J. (2002) P24, a glycogen synthase kinase 3 (GSK 3) inhibitor. Biochim. Biophys. Acta 1586, 113-122.
12. Lindersson, E., Lundvig, D., Petersen, C., Madsen, P., Højrup, P., Moos, T., Otzen, D. E., Gai, W.-P., and Jensen, P. H. (2005) P25a is coexpressed with α-synuclein in α-synucleinopathies and stimulates its aggregation. J. Biol. Chem. 280, 5703-5715.
13. Patrick, G. N., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P., and Tsai, L.-H. (1999) Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402, 615-622.
14. Tirián, L., Hlavanda, E., Oláh, J., Horváth, I., Orosz, F., Szabó, B., Kovács, J., Szabad, J., and Ovádi, J. (2003) p25 promotes tubulin assemblies and blocks mitotic spindle formation. Proc. Natl. Acad. Sci. USA 100, 13976-13981.
15. Kovács, G. G., László, L., Kovács, J., Jensen, P. H., Lindersson, E., Botond, G., Molnár, T., Perczel, A., Hudecz, F., Mezo, G., Erdei, A., Tirián, L., Lehotzky, A., Gelpi, E., Budka, H., and Ovádi, J. (2004) Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies. Neurobiol. Dis. 17, 155-162.
16. Otzen D. E., Lundvig, D. M., Wimmer, R., Nielsen, L. H., Pedersen, J. R., and Jensen, P. H. (2005) p25alpha is flexible but natively folded and binds tubulin with oligomeric stoichiometry. Protein Sci. 14, 1396-409.
17. Lehotzky, A., Tirián, L., Tökési, N. Lénárt, P., Szabó, B., Kovács, J., and Ovádi, J. (2004) Dynamic targeting of microtubules by TPPP/p25 affects cell survival. J. Cell Sci. 117, 6249-6259.
18. Li, J. B, Gerdes, J. M., Haycraft, C. J., Fan, Y., Teslovich, T. M., May-Simera, H., Li, H., Blacque, O. E., Li, L., Leitch, C. C., Lewis, R. A., Green, J. S., Parfrey, P. S., Leroux, M. R., Davidson, W. S., Beales, P. L., Guay-Woodford, L. M., Yoder, B. K., Stormo, G. D., Katsanis, N., and Dutcher, S. K. (2004) Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. Cell 117, 541-552.
19. Avidor-Reiss, T., Maer, A.M., Koundakjian, E., Polyanovsky, A., Keil, T., Subramaniam, S., and Zuker C. S. (2004) Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Cell 117, 527-539.
20. Hinchcliffe, E. H., Miller, F. J., Cham, M., Khodjakov, A., and Sluder, G. (2001) Requirement of a centrosomal activity for cell cycle progression through G1 into S phase. Science 291, 1547-1550.
21. Khodjakov, A., and Rieder, C. L. (2001) Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression. J. Cell Biol. 153, 237-242.
22. Takahashi, M., Tomizawa, K., Fujita, S. C., Sato, K., Uchida, T., and Imahori, K. (1993) A brain-specific protein p25 is localized and associated with oligodendrocytes, neuropil, and fiber-like structures of the CA3 hippocampal region in the rat brain. J. Neurochem. 60, 228-235.
23. Nelson, T. J., Backlund, Jr., P. S., and Alkon, D. L. (2004) Hippocampal protein-protein interactions in spatial memory. Hippocampus 14, 46-57.
24. Collins, M. O. Yu, L. Coba, M. P., Husi, H., Campuzano, I., Blackstock, W. P., Choudhary, J. S., and Grant, S. G. N. (2005) Proteomic analysis of in vivo phosphorylated synaptic proteins J. Biol. Chem. 280, 5972-5982.
25. John, B., Enright, A., Aravin, A., Tuschl, T., Sander, C., and Marks, D. S., (2004) Human microRNA targets. PLoS Biol. 2(11): e363.