Total synthesis of racemosol and de-O-methylracemosol, potent cyclooxygenase (COX) inhibitors and antimalarial agents

Tetrahedron Letters

Volumn 47, Issue 3, 2006, Pages 345-348

  Sae Lao, Patcharaporn ^a   Kittakoop, Prasat ^b   Rajviroongit, Shuleewan ^a  

^a Mahidol University   (Thailand)

^b NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; DE O METHYLRACEMOSOL; PROSTAGLANDIN SYNTHASE INHIBITOR; RACEMOSOL; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DEMETHYLATION; DRUG SYNTHESIS; LITHIATION;

EID: 28844486620     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.11.016     Document Type: Article

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14. 4), filtered and concentrated in vacuo. Chromatography on silica gel (hexanes) gave 7 as a colourless oil (0.24 g, 71%).
15. 6: C, 67.36; H, 7.00%. Found: C, 67.74; H, 6.89%.
16. 6: C, 68.74; H, 6.29%. Found: C, 68.93; H, 6.47%.
17. F.M. Hauser, R.P. Rhee, S. Prasanna, S.M. Weinreb, and J.H. Dodd Synthesis 1980 72 74
18. N. Thasana, and S. Ruchirawat Synlett 2003 1037 1039
19. 5: C, 70.16; H, 6.48%. Found: C, 70.34; H, 6.12%.
20. 5: C, 72.34; H, 7.59%. Found: C, 72.79; H, 7.84%.
21. 5: C, 69.50; H, 6.14%. Found: C, 69.41; H, 6.20%.
22. 5: C, 74.62; H, 6.26%. Found: C, 74.95; H, 5.93%.
23. 5: C, 75.92; H, 7.22%. Found: C, 75.89; H, 6.90%.
24. 4: C, 75.38; H, 7.15%. Found: C, 75.64; H, 7.11%.
25. 4: C, 74.97; H, 7.66%. Found: C, 74.69; H, 7.43%.
26. G. Gopalakrishnan, V. Kasinath, S.N.D. Pradeep, S.S. Thirumurugan, S. Raj, and G. Shanmugan Molecules 5 2000 880 885
27. 4: C, 74.06; H, 6.21%. Found: C, 73.82; H, 6.41%.
28. 4: C, 73.60; H, 6.79%. Found: C, 73.44; H, 7.00%.
29. 4: C, 74.09; H, 7.11. Found: C, 74.11; H, 7.40.