In vitro elution and mechanical properties of antibiotic-loaded SmartSet HV and Palacos R acrylic bone cements;In-vitro-freisetzung von antibiotika aus SmartSet HV-und Palacos R-knochenzement und deren einfluss auf die mechanischen eigenschaften

Orthopade

Volumn 34, Issue 12, 2005, Pages 1255-1262

  Simpson, P M S ^a   Dall, G F ^a   Breusch, S J ^a   Heisel, C ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Antibiotic; Bone cement; Gentamicin; Palacos; Vancomycin

Indexed keywords

ACRYLIC ACID DERIVATIVE; ANTIBIOTIC AGENT; BONE CEMENT; GENTAMICIN; VANCOMYCIN;

ARTICLE; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; ELUTION; FLUORESCENCE POLARIZATION; HUMAN; IMMUNOASSAY; IN VITRO STUDY; YOUNG MODULUS;

ADHESIVENESS; ANTI-BACTERIAL AGENTS; BIOCOMPATIBLE MATERIALS; DIFFUSION; DRUG CARRIERS; DRUG COMBINATIONS; ELASTICITY; GENTAMICINS; MATERIALS TESTING; MECHANICS; POLYMETHYL METHACRYLATE; STRESS, MECHANICAL; TENSILE STRENGTH; VANCOMYCIN;

EID: 28844467561     PISSN: 00854530     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00132-005-0861-2     Document Type: Article

References (17)

1. Altman D (1991) Practical statistics for medical research. Chapman & Hall, London
2. Armstrong MS, Spencer RF et al. (2002) Mechanical characteristics of antibiotic-laden bone cement. Acta Orthop Scand 73(6): 688-690
3. Bertazzoni-Minelli E, Caveiari C et al. (2002) Release of antibiotics from polymethylmethacrylate cement. J Chemother 14(5): 492-500
4. Cerretani D, Giorgi G et al. (2002) The in vitro elution characteristics of vancomycin combined with imipenem-cilastatin in acrylic bone-cements: a pharmacokinetic study. J Arthroplasty 17(5): 619-626
5. Ethell MT, Bennett RA et al. (2000) In vitro elution of gentamicin, amikacin, and ceftiofur from polymethylmethacrylate and hydroxyapatite cement. Vet Surg 29(5): 375-382
6. Furnes O, Havelin LI et al. (2004) The Norwegian Arthroplasty Register - Report 2004. Norwegian American Orthopaedic Society, Oslo, 14. May 2004
7. Gonzalez Della Valle A, Bostrom M et al. (2001) Effective bactericidal activity of tobramycin and vancomycin eluted from acrylic bone cement. Acta Orthop Scand 72(3): 237-240
8. Harper EJ, Bonfield W (2000) Tensile characteristics often commercial acrylic bone cements. J Biomed Mater Res 53(5): 605-616
9. Herberts P, Malchau H (2003) Annual Report 2003. Swedish National Hip Arthroplasty Register, Stockholm
10. Joseph TN, Chen AL et al. (2003) Use of antibiotic-impregnated cement in total joint arthroplasty. J Am Acad Orthop Surg 11(1): 38-47
11. Kühn KD, Ege W, Gopp U (2005) Acrylic bone cements - Composition and properties. Orthop Clin North Am 36: 17-28
12. Kühn KD, Ege W, Gopp U (2005) Acrylic bone cements - Mechanical and physical properties. Orthop Clin North Am 36: 29-39
13. Klekamp J, Dawson JM et al. (1999) The use of vancomycin and tobramycin in acrylic bone cement: biomechanical effects and elution kinetics for use in joint arthroplasty. J Arthroplasty 14(3): 339-346
14. Lautenschlager EP, Jacobs JJ et al. (1976) Mechanical properties of bone cements containing large doses of antibiotic powders. J Biomed Mater Res 10(6): 929-938
15. Penner MJ, Duncan CP et al. (1999) The in vitro elution characteristics of antibiotic-loaded CMW and Palacos-R bone cements. J Arthroplasty 14(2): 209-214
16. Picknell B, Mizen L et al. (1977) Antibacterial activity of antibiotics in acrylic bone cement. J Bone Joint Surg Br 59(3): 302-307
17. Wahlig H, Dingeldein E (1980) Antibiotics and bone cements. Experimental and clinical long-term observations. Acta Orthop Scand 51(1): 49-56