Favourable modulation of the inflammatory changes in hypercholesterolemic atherogenesis by a low-molecular-weight heparin derivative

International Journal of Cardiology

Volumn 106, Issue 3, 2006, Pages 338-347

  Deepa, P R ^a   Varalakshmi, P ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Atherogenesis; Heparin; Hypercholesterolemia; Inflammation; Low molecular weight heparin; Oxidative stress

Indexed keywords

ACETYLGLUCOSAMINIDASE; C REACTIVE PROTEIN; CATHEPSIN D; CERTOPARIN; CERTOPARIN SODIUM TROPANIN; CERTOPARIN SODIUM TROPARIN; CHOLESTEROL; CHOLIC ACID; FIBRINOGEN; GALACTOSAMINIDASE; GLUCOSAMINIDASE; GLUTATHIONE; HEPARIN DERIVATIVE; HEXOSAMINE; HEXOSE; HEXURONIC ACID; LOW MOLECULAR WEIGHT HEPARIN; NITRIC OXIDE; SIALIC ACID; SODIUM CHLORIDE; THIOL DERIVATIVE; THIOURACIL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; BIOCHEMISTRY; CHOLESTEROL DIET; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIETARY INTAKE; DISEASE SEVERITY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ERYTHROCYTE; FEEDING; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LIVER; MALE; NONHUMAN; OSMOTIC FRAGILITY; OXIDATION; PHYSIOLOGY; PLASMA; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN LOCALIZATION; RAT; STATISTICAL SIGNIFICANCE; TISSUE INJURY;

ANIMALS; ANTICOAGULANTS; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; BLOOD PROTEINS; DISEASE MODELS, ANIMAL; HEPARIN, LOW-MOLECULAR-WEIGHT; HYPERCHOLESTEROLEMIA; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 28844458295     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2005.02.012     Document Type: Article

References (73)

1. R. Scalia, J.Z. Appel III, and A.M. Lefer Leukocyte-endothelium interaction during the early stages of hypercholesterolemia in the rabbit: role of P-selectin, ICAM-1 and VCAM-1 Arterioscler Thromb Vasc Biol 18 1998 1093 1100
2. K.Y. Stokes, E.C. Clanton, J.M. Russell, C.R. Ross, and D.N. Granger NAD(P)H oxidase-derived superoxide mediates hypercholesterolemia-induced leukocyte-endothelial cell adhesion Circ Res 88 2001 499 505
3. K.Y. Stokes, D. Cooper, A. Tailor, and D.N. Granger Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide Free Radic Biol Med 33 2002 1026 1036
4. P.R. Deepa, and P. Varalakshmi Salubrious effect of low molecular weight heparin on atherogenic diet-induced cardiac, hepatic and renal lipid peroxidation and collapse of antioxidant defences Mol Cell Biochem 254 2003 111 116
5. H. Engelberg Actions of heparin in the atherosclerotic process Pharmacol Rev 48 2 1996 327 352
6. A. Salas, M. Sans, A. Soriano, J.C. Reverter, D.C. Anderson, and J.M. Pique Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism Gut 47 1 2000 88 96
7. D. Green, J. Hirsh, J. Heit, M. Prins, B. Davidson, and A.W.A. Lensing Low molecular weight heparin: a critical analysis of clinical trials Pharmacol Rev 46 1 1994 89 109
8. J.A. Sjoland, R. Smith Pedersen, J. Jespersen, and J. Gram Intraperitoneal heparin reduces peritoneal permeability and increases ultrafiltration in peritoneal dialysis patients Nephrol Dial Transplant 19 5 2004 1264 1268
9. B. Xia, H. Han, K.J. Zhang, J. Li, G.S. Guo, and L.L. Gong Effects of low molecular weight heparin on platelet surface P-selectin expression and serum interleukin-8 production in rats with trinitrobenzene sulphonic acid-induced colitis World J Gastroenterol 10 5 2004 729 732
10. S. Benchetrit, E. Golan, E. Podjarny, J. Green, G. Rashid, and J. Bernhein Low-molecular-weight heparin reduces proteinuria and modulates glomerular TNF-α production in the early phase of Adriamycin nephropathy Nephron 87 2001 155 160
11. H.C. Lempert Determination of plasma protein H. Varley Practical clinical biochemistry 4th ed. 1969 CBS Publishers New Delhi, India 233
12. G.P. Talwar Non-isotopic immunoassays and their applications G.P. Talwar 1983 Vikas Publishing House PVT Ltd India 55 62
13. J. Sedlak, and R.H. Lindsay Estimation of total protein bound and non-protein bound sulfhydryl groups in the tissue with Ellman's reagent Anal Biochem 25 1968 192 205
14. M. Orlowski, and A. Meister Isolation of γ-glutamyl transpeptidase from hog kidney J Biol Chem 240 1965 338 347
15. W.H. Habig, M.J. Pabst, and W.B. Jacob Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation J Biol Chem 249 1973 7130 7139
16. G.E.J. Staal, J. Visser, and C. Veeger Purification and properties of glutathione reductase of human erythrocytes Biochim Biophys Acta 185 1969 39 48
17. J. King The hydrolases-acid and alkaline phosphatases D. Van Practical clinical enzymology 1965 Nostrand Company Limited London 191 208
18. D. Marhun Rapid colorimetric assay of β-galactosidase and N-acetyl-β-galactosaminidase in human urine Clin Chim Acta 73 1976 453 461
19. Y. Kawai, and K. Anno Mucopolysaccharide-degrading enzymes from the liver of the squid, Ommastrephes saloni pacificus: I. Hyaluronidase Biochim Biophys Acta 242 1971 428 436
20. D.J. Etherington The nature of collagenolytic cathepsin of rat liver and its distribution in other rat tissues Biochem J 127 1972 685 692
21. P. Niebes Determination of enzymes and degradation products of glycosaminoglycan metabolism in the serum of healthy and varicose subjects Clin Chim Acta 42 1972 399 408
22. W.D. Wagner More sensitive assay discriminating galactosamine and glucosamine in mixtures Anal Biochem 94 1979 394 397
23. T. Bitter, and H.M. Muir Modified uronic acid-carbazole reaction Anal Biochem 4 1962 330 334
24. D. Aminoff Methods for the quantitative estimation of N-acetyl-neuraminic acid and their application to hydrolysates of sialomucoids Biochem J 81 1961 384 392
25. R. Usha, and K.S. Swaroop Special hematological test K.L. Mukherjee Medical laboratory technology-a procedure manual for routine diagnostics tests 1988 Tata McGraw Hill Publishing Company Limited New Delhi 308 346
26. B. Lindahl, H. Toss, A. Siegbahn, P. Venge, and L. Wallentin Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group. Fragmin during instability in coronary artery disease N Engl J Med 343 2000 1139 1147
27. T.W. Meade Risk associations in the thrombotic disorders Clin Haematol 10 1981 391 405
28. T. Ishida, and K. Tanaka Effects of fibrin and fibrinogen-degradation products on the growth of rabbit aortic smooth muscle cells in culture Atherosclerosis 44 1982 161 174
29. D.P. Mikhailidis, M.A. Barradas, A. Maris, J.Y. Jeremy, and P. Dandona Fibrinogen mediated activation of platelet aggregation and thromboxane A2 release: pathological implications in vascular disease J Clin Pathol 38 1985 1166 1171
30. P.M. Ridker, M. Cushman, M.J. Stampfer, R.P. Tracy, and C.H. Hennekens Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men N Engl J Med 336 1997 973 979
31. H. Toss, B. Lindahl, A. Siegbahn, and L. Wallentin Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease. FRISC Study Group. Fragmin during instability in coronary artery disease Circulation 96 1997 4204 4210
32. S. Fichtlscherer, and A.M. Zeiher Endothelial dysfunction in acute coronary syndromes: association with elevated C-reactive protein levels Ann Med 32 2000 515 518
33. H. Engelberg Low-dose intermittent heparin therapy decreases plasma fibrinogen levels Semin Thromb Haemost 17 1991 211 215
34. C.K. Chow Vitamin E and oxidative stress Free Radic Biol Med 11 1991 215 232
35. K. Prasad, and J. Kalra Oxygen free radicals and hypercholesterolemic atherosclerosis Am Heart J 125 1993 958 971
36. C. Gokkusu, and T. Mostafazadeh Changes of oxidative stress in various tissues by long-term administration of vitamin E in hypercholesterolemic rats Clin Chim Acta 328 2003 155 161
37. A. Mezzetti, D. Lapenna, A.M. Calfiore, G. Proietti-Franceschilli, E. Porreca, and D. De Cesare Glutathione-related enzyme activities and lipoperoxide concentrations in human internal mammary artery and ascending aorta Arterioscler Thromb 12 1992 92 98
38. J.N. Dhuley, and S.R. Naik Increased γ-glutamyl transpeptidase activity during inflammation and its inhibition by 6-MFA, a metabolite obtained from Aspergillus ochraceus Pharm Pharmacol Commun 6 2000 465 469
39. Y. Takenaka, M. Miki, H. Yasuda, and M. Mino The effect of a-tocopherol as an antioxidant on the oxidation of membrane protein thiols induced by free radicals generated in different sites Arch Biochem Biophys 285 1991 344 350
40. H. Sies Glutathione and its role in cellular functions Free Radic Biol Med 27 1999 916 921
41. D. Grant, W.F. Long, and F.B. Williamson Pericellular heparans may contribute to the protection of cells from free radicals Med Hypotheses 23 1987 67 71
42. T. Zemplenyi, D.F. Tidwell, and K. Fronek Aortic enzymes and lactate in high altitude-raised and cholesterol-fed rabbits Atherosclerosis 52 1984 233 242
43. C. De Duve The participation of lysosomes in the transformation of smooth muscle cells to foamy cells in the aorta of cholesterol-fed rabbits Acta Cardiol 20 1974 9 25
44. H. Wolinksy Role of lysosomes in vascular disease: a unifying theme Ann N Y Acad Sci 275 1976 238 243
45. C. De Duve, and R. Wattiaux Functions of lysosomes Annu Rev Physiol 28 1966 435 492
46. B.F. Miller, and H.V. Kothari Increased activity of lysosomal enzymes in human atherosclerotic aortas Exp Mol Pathol 10 1969 288 294
47. G.G. Ecsedi, S. Virag, and E.J. Hidvegi Effect of CH-1243, a pyrido (1,2-a) pyrimidine derivative on the elevated activity of lysosomal enzymes of rabbit aorta and liver in experimental atherosclerosis Atherosclerosis 39 1981 183 190
48. T. Zemplenyi, O. Mrhova, D. Urbanova, and M. Kohout Vascular enzyme activities and susceptibility of arteries to atherosclerosis Ann N Y Acad Sci 149 1968 682 698
49. R.N. Mullinger, and G. Manley Glycosaminoglycans and atherosclerosis in animal aortas J Atheroscler Res 9 1969 108 111
50. S. Virag, G. Sebestyen, M. Kovacs, and P. Kapp Effect of CH-123 on vascular cholesterol deposition in experimental atherosclerosis of rabbits Acta Morphol Acad Sci Hung 27 1979 37 52
51. B. Radhakrishnamurthy, E.R. Dalferes Jr., and G.S. Berenson Determination of hexosamines by gas-liquid chromatography Anal Biochem 17 1966 545 550
52. B. Radhakrishnamurthy, H.A. Ruiz, E.R. Dalferes Jr., S.R. Srinivasan, T.A. Foster, and G.S. Berenson Studies of arterial wall glycosaminoglycans and collagen during experimental regression of atherosclerotic lesions in cynomolgus monkeys Lab Invest 47 1982 153 159
53. J.R. Crook, J.H. Goldman, M. Dalziel, B. Madden, and W.J. McKenna Increased ventricular sialylation in patients with heart failure secondary to ischemic heart disease Clin Cardiol 20 1997 455 458
54. + permeability on sialic acid-containing sarcolemmal gangliosides J Mol Cell Cardiol 30 1998 127 137
55. S. Maruyama, K. Kato, M. Kodama, S. Hirono, K. Fuse, and O. Nakagawa Fenofibrate, a peroxisome proliferator-activated receptor alpha activator, suppresses experimental autoimmune myocarditis by stimulating the interleukin-10 pathway in rats J Atheroscler Thromb 9 2002 87 92
56. O. Berkan, and M. Sagban Sialic acid or troponin T to detect perioperative myocardial damage in patients undergoing elective coronary artery bypass grafting Circ J 66 2002 1019 1023
57. D.N. Granger Ischemia/reperfusion: mechanisms of microvascular dysfunction and the influence of risk factors for cardiovascular disease Microcirculation 6 1999 167 178
58. B.E. Brito, E.L. Romano, and C. Grunfeld Increased lipopolysaccharide- induced tumour necrosis factor levels and death in hypercholesterolaemic rabbits Clin Exp Immunol 101 2 1995 357 361
59. A.S. Yalcin, N. Sabuncu, A. Kilinc, G. Gulcan, and K. Emerk Increased plasma and erythrocyte lipid peroxidation in hyperlipidemic individuals Atherosclerosis 80 1989 169 170
60. J.M. Weiler, R.E. Edens, R.J. Linhardt, and D.P. Kapelanski Heparin and modified heparin inhibit complement activation in vivo J Immunol 148 1992 3210 3215
61. P.R. Deepa, and P. Varalakshmi Favourable influence of low molecular weight heparin in mitigating the peroxidative membrane damage induced by a cytotoxic agent and an atherogenic diet Hum Exp Toxicol 22 2003 229 235
62. G. Deliconstantinos, V. Villiotou, and J.C. Stavrides Modulation of particulate nitric oxide synthase activity and peroxynitrite synthesis in cholesterol enriched endothelial cell membranes Biochem Pharmacol 49 1995 1589 1600
63. A. Onody, C. Csonka, Z. Giricz, and P. Ferdinandy Hyperlipidemia induced by a cholesterol-rich diet leads to enhanced peroxynitrite formation in rat hearts Cardiovasc Res 58 2003 663 670
64. C. Napoli, and L.J. Ignarro Nitric oxide and atherosclerosis Nitric Oxide 5 2001 88 97
65. P.J. Kuhlencordt, J. Chen, F. Han, J. Astern, and P.L. Huang Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice Circulation 103 2001 3099 3104
66. S. Kourembanas, L.P. McQuillan, G.K. Leung, and D.V. Faller Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia J Clin Invest 92 1993 99 104
67. J.P. Cooke, A.H. Singer, P. Tsao, P. Zera, R.A. Rowan, and M.E. Billingham Antiatherogenic effects of l-arginine in the hypercholesterolemic rabbit J Clin Invest 90 1992 1168 1172
68. K. Yokokawa, A.K. Mandal, M. Kohno, T. Horio, K. Murakawa, and K. Yasunari Heparin suppresses endothelin-1 action and production in spontaneously hypertensive rats Am J Physiol 263 1992 R1035 R1041
69. T. Imai, Y. Hirata, T. Emori, and F. Marumo Heparin has an inhibitory effect on endothelin-1 synthesis and release by endothelial cells Hypertension 21 1993 353 358
70. M. Kohno, K. Yokokawa, T. Horio, M. Ikeda, N. Kurihara, and A.K. Mandal Heparin inhibits endothelin-1 production in cultured rat mesangial cells Kidney Int 45 1994 137 142
71. K. Yokokawa, H. Tahara, M. Kohno, A.K. Mandal, M. Yanagisawa, and T. Takeda Heparin regulates endothelin production through endothelium-derived nitric oxide in human endothelial cells J Clin Invest 92 1993 2080 2085
72. J.T. Light Jr., J.A. Bellan, M.P. Roberts, S.D. Force, I.L. Chen, and M.D. Kerstein Heparin treatment enhances the recovery of neoendothelial acetylcholine-induced vascular relaxation after balloon catheter injury in the rabbit aorta Circulation 88 1993 413 419
73. J. Mattana, and P.C. Singhal Heparin attenuates the effect of mitogenic vasoconstrictors on mesangial cell proliferation and handling of immunoglobulin G complexes J Pharmacol Exp Ther 273 1995 80 87