Ovarian Leydig cell tumor in a peri-menopausal woman with severe hyperandrogenism and virilization

Gynecological Endocrinology

Volumn 21, Issue 4, 2005, Pages 238-241

  Nardo, L G ^a   Ray, D W ^b   Laing, I ^b   Williams, C ^b   McVey, R J ^b   Seif, M W ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Hyperandrogenism; Ovarian Leydig cell tumor; Peri menopause; Selective venous sampling; Virilization

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; ANTIDEPRESSANT AGENT; HYDROCORTISONE; HYDROXYPROGESTERONE; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ABDOMINAL HYSTERECTOMY; ADULT; AGORAPHOBIA; ANAMNESIS; ANDROGEN RELEASE; ANXIETY DISORDER; ARTICLE; BIOCHEMISTRY; CANCER REGRESSION; CASE REPORT; CLIMACTERIUM; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE SEVERITY; ECHOGRAPHY; FEMALE; HISTOPATHOLOGY; HUMAN; HYPERANDROGENISM; INTRAOPERATIVE PERIOD; LABORATORY TEST; LEYDIG CELL TUMOR; OVARIAN VEIN; OVARY TUMOR; PELVIS; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SALPINGOOOPHORECTOMY; SYMPTOMATOLOGY; VIRILIZATION;

ANDROGENS; FALLOPIAN TUBES; FEMALE; HUMANS; HYPERANDROGENISM; HYSTERECTOMY; LEYDIG CELL TUMOR; MIDDLE AGED; OVARIAN NEOPLASMS; OVARIECTOMY; OVARY; TESTOSTERONE; TOMOGRAPHY, X-RAY COMPUTED; ULTRASONOGRAPHY; VEINS; VIRILISM;

EID: 28844450739     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.1080/09513590500369005     Document Type: Article

References (16)

1. Takeuchi S, Ishihara N, Ohbayashi C, Itoh H, Maruo T. Stromal Leydig cell tumour of the ovary. Case report and literature review. Int J Gynecol Pathol 1999;18:178-182.
2. Antoniou N, Varras M, Akrivis CH, Demou A, Bellou A, Stefanaki S. Mucinous cystadenoma of the ovary with functioning stroma and virilization in pregnancy: A case report and review of the literature. Clin Exp Obstet Gynecol 2003;30:248-252.
3. Pugeat M, Mirakian P, Dutrieux-Berger N, Forest MG, Tourniaire J. Androgen secreting ovarian neoplasm. In: Azziz R, Nestler JE, Dewailly D, editors. Androgen excess disorders in women. New York: Lippincott-Raven; 1997. pp 555-568.
4. Kaltsas GA, Mukherjee JJ, Kola B, Isidori AM, Hanson JA, Daciet JE, Reznek R, Monson JP, Grossman AB. Is ovarian and adrenal venous catheterization and sampling helpful in the investigation of hyperandrogenic women? Clin Endocrinol 2003;59:34-43.
5. Earth JH, Jenkins PM, Belchetz P. Ovarian hyperhecosis, diabetes and hirsuties in post-menopausal women. Clin Endocrinol 1997;46:123-128.
6. Ayuk P, Stringfellow H, Donnai P, Beardwell CG, Holt A, Laing I. Hirsutism of recent onset with marked hyperandrogenaemia after the menopause. Ann Clin Biochem 1998;35:145-148.
7. Monteagudo A, Heller D, Husami N, Levine RU, McCaffrey R, Timor-Tritsch IE. Ovarian steroid cell tumours: Sonographic characteristics. Ultrasound Obstet Gynecol 1997;10:282-288.
8. Judd HL, Scully RE, Herbst AL, Yen SS, Ingersol FM, Kliman B. Familial hyperthecosis: comparison of endocrinologic and histologic findings with polycystic ovarian disease. Am J Obstet Gynecol 1973;117:976-982.
9. Surrey ES, de Ziegler D, Gambone JC, Judd HL. Preoperative localization of androgen secreting tumours: clinical, endocrinologic and radiologic evaluation of ten patients. Am J Obstet Gynecol 1988;158:1313-1322.
10. Outwater EK, Marchetto B, Wagner BJ. Virilizing tumors of the ovary: Imaging features. Ultrasound Obstet Gynecol 2000;15:365-371.
11. Varras M. Benefits and limitations of ultrasonographic evaluation of uterine adnexal lesions in early detection of ovarian cancer. Clin Exp Obstet Gynecol 2004;31:85-98.
12. Moltz L, Schwartz U, Sorensen R, Pickartz H, Hammerstein J. Ovarian and adrenal vein steroids in patients with non-neoplastic hyperandrogenism: Selective catheterization findings. Fertil Steril 1984;42:69-75.
13. Stephens JW, Katz JR, McDermott N, MacLean AB, Bouloux PM. An unusual steroid-producing ovarian tumour: case report. Hum Reprod 2002;17:1468-1471.
14. Sorensen R, Moltz L, Schwartz U. Technical difficulties of selective blood sampling in the differential diagnosis of female hyperandrogenism. Cardiovasc Intervent Radiol 1986;9:75-82.
15. Amato G, Izzo G, Izzo A. A paradoxical inhibition of androgenic hyperproduction by a Sertoli-Leydig cell tumour ovary. Hum Reprod 1995;10:2967-2969.
16. Surbeck DV, Hoesli I, Torhorst J, Almendral AC, Dellas A, Holzgreve W. Virilizing ovarian tumour of low malignant potential associated with antecedent tamoxifen use for breast cancer. Gynecol Oncol 1998;68:293-296.