Lack of carcinogenicity of L-isoleucine in F344/DuCrj rats

Food and Chemical Toxicology

Volumn 44, Issue 2, 2006, Pages 278-285

  Kawabe, Mayumi ^a,b   Sano, Masashi ^a,b   Hagiwara, Akihiro ^a,b   Tamano, Seiko ^a,b   Suzuki, Shugo ^b   Shirai, Tomoyuki ^b  

^a Daiyukai Research Institute for Medical Science   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

Amino acid; Carcinogenicity study; F344 rats; Food additive; L Isoleucine

Indexed keywords

ISOLEUCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER INCIDENCE; CARCINOGENICITY; CLINICAL CHEMISTRY; CONCENTRATION (PARAMETERS); DIET; FEMALE; FOOD INTAKE; HEMATOLOGY; HISTOPATHOLOGY; MALE; NEOPLASM; NONHUMAN; ORGAN WEIGHT; RAT; SURVIVAL RATE; URINALYSIS;

ANIMALS; BEHAVIOR, ANIMAL; BLOOD CELL COUNT; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; CARCINOGENS; DIET; FEMALE; ISOLEUCINE; MALE; ORGAN SIZE; RATS; RATS, INBRED F344; SEX CHARACTERISTICS;

ANIMALIA;

EID: 28844438928     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2005.07.011     Document Type: Article

References (26)

1. R.L. Anderson, F.R. Lefever, and J.K. Maurer Effect of inherent urine output on the response on male rats to 7.5% dietary sodium saccharin Food and Chemical Toxicology 25 1987 641 645
2. G.T. Bryan The role of urinary tryptophan metabolites in the etiology of bladder cancer American Journal of Clinical Nutrition 24 1971 841 847
3. S.M. Cohen, M. Arai, J.B. Jacobs, and G.H. Friedell Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis Cancer Research 39 1979 1207 1217
4. G.A. Dienel Chronic hyperphenylalaninemia produces cerebral hyperglycinemia in immature rats Journal of Neurochemistry 36 1981 34 43
5. R.G. Daniel, and H.A. Waisman The effects of excess amino acids on the growth of the young rat Growth 32 1968 255 265
6. S. Fukushima, G.H. Friedell, J.B. Jacobs, and S.M. Cohen Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide Cancer Research 41 1981 3100 3103
7. S. Fukushima, A. Hagiwara, T. Ogiso, M. Shibata, and N. Ito Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl-(4-hydroxybutyl)amine Food and Chemical Toxicology 21 1983 59 68
8. S. Fukushima, M.-A. Shibata, T. Shirai, S. Tamano, and N. Ito Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis in rats Cancer Research 46 1986 1623 1626
9. S. Fukushima, S. Tamano, M.-A. Shibata, Y. Kurata, M. Hirose, and N. Ito The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder Carcinogenesis 9 1988 1203 1206
10. D.G. Goodman, J.M. Ward, R.A. Squire, K.C. Chu, and M.S. Linhart Neoplastic and nonneoplastic lesions in aging F344 rats Toxicology and Applied Pharmacolology 48 1979 237 248
11. J.K. Haseman, J. Arnold, and S.L. Eustis Tumor incidences in Fischer 344 rats: NTP historical data G.A. Boorman S.L. Eustis M.R. Elwell C.A. Montogomery Jr. W.F. Mackenzie Pathology of the Fischer Rat 1990 Academic Press Inc. San Diego, CA 555 564
12. M. Ishidate Jr., T. Sofuni, K. Yoshikawa, M. Hayashi, T. Nohmi, M. Sawada, and A. Matsuoka Primary mutagenicity screening of food additives currently used in Japan Food and Chemical Toxicology 22 1984 623 636
13. T. Kakizoe, H. Komatsu, Y. Honma, T. Niijima, and T. Sugimura Detection of amino acids as possible promoters of bladder cancer in rats by measuring their enhancement of agglutination of bladder cells by concanavalin A Gann 73 1982 870 873
14. M. Kawabe, Y. Takesada, S. Tamano, A. Hagiwara, N. Ito, and T. Shirai Subchronic toxicity study of L-isoleucine in F344 rats Journal of Toxicology and Environmental Health 47 1996 499 508
15. S.M. Lynch, and J.J. Strain Increased hepatic lipid peroxidation with methionine toxicity in the rat Free Radical Research Communications 5 1989 221 226
16. A. Maekawa, Y. Kurokawa, M. Takahashi, T. Kokubo, T. Ogiu, H. Onodera, H. Tanigawa, Y. Ohno, F. Furukawa, and Y. Hayashi Spontaneous tumors in F-344/DuCrj rats Gann 74 1983 365 372
17. K. Maita, M. Hirano, T. Harada, K. Mitsumori, A. Yoshida, K. Takahashi, N. Nakashima, T. Kitazawa, A. Enomoto, K. Inui, and Y. Shirasu Spontaneous tumors in F344/DuCrj rats from 12 control groups of chronic and oncogenicity studies The Journal of Toxicological Sciences 12 1987 111 126
18. C.D. Malis, L.C. Racusen, K. Solez, and A. Whelton Nephrotoxicity of lysine and of a single dose of aminoglycoside in rats given lysine The Journal of Laboratory and Clinical Medicine 103 1984 660 676
19. M. Matsushima The role of L-tryptophan's promoting factor on tumorigenesis in the urinary bladder. 2. Urinary bladder carcinogenicity of FANFT (initiating factor) and L-tryptophan (promoting factor) in mice Japanese Journal of Urology 68 1977 731 736
20. M. Miyakawa, and O. Yoshida DNA synthesis of the urinary bladder epitherium in rats with long-term feeding of dl-tryptophan-added and pyridoxine-deficient diet Gann 64 1973 411 413
21. Y. Nishio, T. Kakizoe, M. Ohtani, S. Sato, T. Sugimura, and S. Fukushima L-isoleucine and L-leucine: Tumor promoters of bladder cancer in rats Science 231 1986 843 845
22. J.L. Radomski, E.M. Glass, and W.B. Deichmann Transitional cell hyperplasia in the bladders of dogs fed DL-tryptophan Cancer Research 31 1971 1690 1694
23. J.L. Radomski, T. Radomski, and W.E. MacDonald Cocarcinogenic interaction between D,L-tryptophan and 4-aminobiphenyl or 2-naphthylamine in dogs Journal of National Cancer Institute 58 1977 1831 1834
24. A.G. Renwick, and J. Sims Distension of the urinary bladder in rats fed saccharin containing diet Cancer Letters 18 1983 63 68
25. H.E. Sauberlich Studies on the toxicity and antagonism of amino acids for weanling rats The Journal of Nutrition 75 1961 61 72
26. O. Yoshida, R.R. Brown, and G.T. Bryan Relationship between tryptophan metabolism and heterotropic recurrences of human urinary bladder tumors Cancer 25 1970 773 780