The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers

Chemico-Biological Interactions

Volumn 157-158, Issue , 2005, Pages 191-198

  Ordentlich, Arie ^a   Barak, Dov ^a   Sod Moriah, Gali ^a   Kaplan, Dana ^a   Mizrahi, Dana ^a   Segall, Yoffi ^a   Kronman, Chanoch ^a   Karton, Yishai ^a   Lazar, Arie ^a   Marcus, Dino ^a   Velan, Baruch ^a   Shafferman, Avigdor ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

Acyl pocket; Cationic binding subsite; Charged leaving group; Peripheral anionic site (PAS); Phosphate inhibitors

Indexed keywords

ACETYLCHOLINESTERASE; AMMONIA; ASPARAGINE; CATION; CHEMICAL WARFARE AGENT; METHYLPHOSPHONIC ACID; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; PHENYLALANINE; PHOSPHORUS DERIVATIVE; SARIN; SOMAN; TRYPSIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CONFERENCE PAPER; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME KINETICS; HUMAN; MOLECULAR INTERACTION; MUTANT; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; STEREOCHEMISTRY; WILD TYPE;

ACETYLCHOLINESTERASE; ACYLATION; ANIONS; BINDING SITES; CHOLINE; HUMANS; MOLECULAR STRUCTURE; MUTATION; ORGANOTHIOPHOSPHORUS COMPOUNDS; PHENYLALANINE; STEREOISOMERISM;

EID: 28744446707     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.10.026     Document Type: Conference Paper

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