Anti-inflammatory effects of indomethacin's methyl ester derivative and induction of apoptosis in HL-60 cells

Biological and Pharmaceutical Bulletin

Volumn 28, Issue 12, 2005, Pages 2206-2210

  Chao, Su Hui ^a   Wu, An Bang ^a   Lee, Chia Jung ^a   Chen, Fu An ^b   Wang, Ching Chiung ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAJEN INSTITUTE OF TECHNOLOGY   (Taiwan)

Author keywords

Anti inflammatory drug; Apoptosis; Caspase 3; Cyclooxygenase; 1 (4 chloro benzoyl) 5 methoxy 2 methyl indol 3 yl acetic acid methyl ester

Indexed keywords

8 (4 CHLOROBENZOYL) 3A HYDROXY 5 METHOXY 8A METHYL 2 OXO 2,3,3A,8A TETRAHYDRO 1H FURO[2,3 B]INDOLE; CYCLOOXYGENASE 2; DNA FRAGMENT; ESTER DERIVATIVE; GAMMA LACTONE DERIVATIVE; INDOMETACIN; INDOMETACIN DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROCASPASE 3; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; [1 (4 CHLOROBENZOYL) 5 METHOXY 2 METHYLINDOL 3 YL]ACETIC ACID ETHYL ESTER; [1 (4 CHLOROBENZOYL) 5 METHOXY 2 METHYLINDOL 3 YL]ACETIC ACID METHYL ESTER;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STIMULATION; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PHOTOSYNTHESIS; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION;

EID: 28744446574     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.28.2206     Document Type: Article

References (16)

1. Presott S. M., Fitzpatrick F. A., Biochim. Biophys. Acta/Reviews on Cancer, 1470, M69-M78 (2000).
2. Lim J. T. E., Piazza G. A., Han E. K. H., Delohery T. M., Li H., Finn T. S., Buttyan R., Yamamoto H., Sperl G. J., Brendel K., Gross P. H., Pamukcu R., Weinstein I. B., Biochem. Pharmacol., 58, 1097-1107 (1999).
3. Zhu G. H., Wong B. C. Y., Eoog M. C., Ching C. K., Yuen S. T., Chan E. Y. T., Lai K. C., Lam S. K., Br. J. Cancer, 79, 393-400 (1999).
4. Zhou X. M., Wong B. C., Fan X. M., Zhang H. B., Lin M. C., Kung H. F., Fan D. M., Lam S. K., Carcinogenesis, 22, 1393-1397 (2001).
5. de Groot D. J., Timmer T., Spierings D. C. J., Le T. K. P., de Jong S., de Vries E. G., Br. J. Cancer, 92, 1459-1466 (2005).
6. Wu A. B., Cheng W. H., Hu C. M., Chen F. A., Chou T. C., Chen C.Y., Tetrahedron Lett., 38, 621-622 (1997).
7. Cochran F. G., Selph J., Sherman P., Med. Res. Rev., 16, 547-563 (1996).
8. Wink D. A., Kasprzak K. S., Maragos C. M., Elespuru R. K., Misra M., Dunams T. M., Allen J. S., Keefer L. K., Science, 254, 1001-1002 (1991).
9. Heitmeier M. R., Scarim A. L., Corbett J. A., J. Biol. Chem., 273, 15301-15307 (1998).
10. Allen R. T., Hunter III W. J., Agrawal D. K., J. Pharmacol. Toxicol. Meth., 37, 215-228 (1997).
11. Wang C. C., Chen L. G., Yang L. L., Cancer Lett., 149, 77-83 (2000).
12. Williams C. S., Mann M., Dubois R. N., Oncogene, 18, 7908-7916 (1999).
13. Berg J., Fellier H., Christoph T., Grarup J., Stimmeder D., Inflamm. Res., 48, 369-379 (1999).
14. Kalgutkar A. S., Marnett A. B., Crews B. C., Remmel R. P., Marnett L. J., J. Med. Chem., 43, 2860-2870 (2000).
15. Decker P., Muller S., Curr. Pharm. Biotechnol., 3, 275-283 (2002).
16. Concha N. O., Abdel-Meguid S. S., Curr. Med. Chem., 9, 713-726 (2002).