Different B-cell populations are responsible for the peripheral and intrathecal antibody production in neuroborreliosis

International Immunology

Volumn 17, Issue 12, 2005, Pages 1631-1637

  Lakos, András ^a   Ferenczi, Emoke ^b   Komoly, Sámuel ^c,d   Granström, Marta ^e  

^a Center for Tick borne Diseases   (Hungary)

^b NATIONAL CENTER FOR EPIDEMIOLOGY   (Hungary)

^c Jahn Ferenc Del Pesti korhaz Budapest   (Hungary)

^d UNIVERSITY OF PÉCS   (Hungary)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Borrelia burgdorferi; Comparative immunoblot assay; Intrathecal antibody synthesis; Lyme disease; Neuroborreliosis

Indexed keywords

BACTERIUM ANTIBODY; CEFTRIAXONE;

ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOBLOTTING; INTERMETHOD COMPARISON; LYME DISEASE; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; NEUROLOGIC DISEASE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; RELIABILITY; SENSITIVITY ANALYSIS;

ANTIBODIES, BACTERIAL; ANTIBODY FORMATION; B-LYMPHOCYTES; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; FEMALE; HUMANS; LYME NEUROBORRELIOSIS; MALE;

EID: 28744442190     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxh343     Document Type: Article

References (29)

1. Steere, A. C. 2001. Lyme disease. N. Engl. J. Med. 345:115.
2. Hansen, K. 1994. Lyme neuroborreliosis: Improvements of the laboratory diagnosis and a survey of epidemiological and clinical features in Denmark 1985-1990. Acta Neurol. Scand. Suppl. 151:1.
3. Hansen, K. and Lebech, A. M. 1992. The clinical and epidemiological profile of Lyme neuroborreliosis in Denmark 1985-1990. A prospective study of 187 patients with Borrelia burgdorferi specific intrathecal antibody production. Brain 115:399.
4. Steere, A. C., Berardi, V. P., Weeks, K. E., Logigian, E. L. and Ackermann, R. 1990. Evaluation of the intrathecal antibody response to Borrelia burgdorferi as a diagnostic test for Lyme neuroborreliosis. J. Infect. Dis. 161:1203.
5. Stanek, G., O'Connell, S., Cimmino, M. et al. 1996. European union concerted action on risk assessment in Lyme Borreliosis: Clinical case definitions for Lyme borreliosis. Wien. Klin. Wochenschr. 108:741.
6. Centers for Disease Control. 1997. Case definitions for infectious conditions under public health surveillance. Morb. Mortal. Wkly. Rep. 46:1.
7. Brouqui, P., Bacellar, F., Baranton, G. et al. 2004. Guidelines for the diagnosis of tick-borne bacterial diseases in Europe. Clin. Microbiol. Infect. 10:1108.
8. Kaiser, R. 2000. False-negative serology in patients with neuroborreliosis and the value of employing of different borrelial strains in serological assays. J. Med. Microbiol. 49:911.
9. Halperin, J. J., Volkman, D. J. and Wu, P. 1991. Central nervous system abnormalities in Lyme neuroborreliosis. Neurology 41:1571.
10. Wilske, B., Schierz, G., Preac-Mursic, V. et al. 1986. Intrathecal production of specific antibodies against Borrelia burgdorferi in patients with lymphocytic meningoradiculitis (Bannwarth's syndrome). J. Infect. Dis. 153:304.
11. Centers for Disease Control. 1995. Lyme disease surveillance summary. 6:1.
12. Murray, N., Kristoferitsch, W., Stanek, G. and Steck, A. J. 1986. Specificity of CSF antibodies against components of Borrelia burgdorferi in patients with meningopolyneuritis Garin-Bujadoux-Bannwarth. J. Neurol. 233:224.
13. Karlsson, M., Möllegard, I., Stiernstedt, G., Henriksson, A. M. and Wretlind, B. 1988. Characterization of antibody response in patients with Borrelia meningitis. Serodiagn. Immunother. Infect. Dis. 2:375.
14. Kaiser, R. and Lucking, C. H. 1993. Intrathecal synthesis of specific antibodies in neuroborreliosis. Comparison of different ELISA techniques and calculation methods. J. Neurol. Sci. 118:64.
15. Schutzer, S. E., Coyle, P. K., Krupp, L. B., Deng, Z., Belman, A. L. and Dattwyler, R. 1997. Simultaneous expression of borrelia OspA and OspC and IgM response in cerebrospinal fluid in early neurologic Lyme disease. J. Clin. Investig. 100:763.
16. Molnár, E. 1982. Occurrence of tick-borne encephalitis and other arboviruses in Hungary. Geogr. Med. 12:78.
17. Nagy, G. and Mezey, I. 1977. The use of ion exchange chromatography for demonstration of rubella-specific IgM antibodies. Acta Microbiol. Acad. Sci. Hung. 24:189.
18. Lakos, A. and Granström, M. 1997. Diagnostic power of immunoblot in Lyme borreliosis (Lb). The 15th Annual Meeting of the European Society for Paediatric Infectious Diseases. Paris, France, 21-23 May. Abstract book, 126.
19. Stiernstedt, G., Granström, M., Hederstedt, B. and Sköldenberg, B. 1985. Diagnosis of spirochetal meningitis by enzyme-linked immunosorbent assay and indirect immunofluorescence assay in serum and cerebrospinal fluid. J. Clin. Microbiol. 21:819.
20. Hansen, K. and Lebech, A. M. 1991. Lyme neuroborreliosis: A new sensitive diagnostic assay for intrathecal synthesis of Borrelia burgdorferi-specific immunoglobulin G, A, and M. Ann. Neurol. 30:197.
21. Zbinden, R., Goldenberger, D., Lucchini, G. M. and Altwegg, M. 1994. Comparison of two methods for detecting intrathecal synthesis of Borrelia burgdorferi-specific antibodies and PCR for diagnosis of Lyme neuroborreliosis. J. Clin. Microbiol. 32: 1795.
22. Picha, D., Moravcová, L., Zdarsky, E. and Benes, J. 2000. Clinical comparison of immunoblot and antibody index for detection of intrathecal synthesis of specific antibodies in Lyme neuroborreliosis. Eur. J. Clin. Microbiol. Infect. Dis. 19:805.
23. Jespersen, D. J., Smith, T. F., Rosenblatt, J. E. and Cockerill, F. R., III. 2002. Comparison of the Borrelia DotBlot G, MarDx, and VIDAS enzyme immunoassays for detecting immunoglobulin G antibodies to Borrelia burgdorferi in human serum. J. Clin. Microbiol. 40:4782.
24. Sopper, S., Sauer, U., Hemm, S. et al. 1998. Protective role of the virus-specific immune response for development of severe neurologic signs in simian immunodeficiency virus-infected macaques. J. Virol. 72:9940.
25. Goudsmit, J., Wolters, E. C., Bakker, M. et al. 1986. Intrathecal synthesis of antibodies to HTLV-III in patients without AIDS or AIDS related complex. Br. Med. J. (Clin. Res. Ed.) 292:1231.
26. Krüger, H., Pulz, M., Martin, R. and Sticht-Groh, V. 1990. Long-term persistence of specific T- and B-lymphocyte responses to Borrelia burgdorferi following untreated neuroborreliosis. Infection 18:263.
27. Krüger, H., Reuss, K., Pulz, M. et al. 1989. Meningoradiculitis and encephalomyelitis due to Borrelia burgdorferi: A follow-up study of 72 patients over 27 years. J. Neurol. 236:322.
28. Halperin, J. J., Krupp, L. B., Gloghtly, M. G. and Volkmann, D. J. 1990. Lyme borreliosis associated encephalopathy. Neurology 40:1340.
29. Lakos, A., Ferenczi, E., Ferencz, A. and Tóth, E. 1997. Tick-borne encephalitis. Parasitol. Hung. 30:5.