(24) Acetylcholinesterase mutants: Oxime-assisted catalytic scavengers of organophosphonates

Chemico-Biological Interactions

Volumn 157-158, Issue , 2005, Pages 388-390

  Kovarik, Zrinka ^a,b   Radić, Zoran ^a   Simeon Rudolf, Vera ^b   Reiner, Elsa ^b   Taylor, Palmer ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; CYCLOHEPTYLMETHYLPHOSPHONYLTHIOCHOLINE; MUTANT PROTEIN; OXIME; PHOSPHONIC ACID DERIVATIVE; SCAVENGER; UNCLASSIFIED DRUG; PYRIDINIUM DERIVATIVE; THIOCHOLINE;

COLORIMETRY; CONFERENCE PAPER; DECOMPOSITION; ENZYME MECHANISM; GENE MUTATION; HIGH THROUGHPUT SCREENING; SPECTROPHOTOMETRY; ANIMAL; ARTICLE; CATALYSIS; GENETICS; METABOLISM; MOUSE; MUTATION; PH;

ACETYLCHOLINESTERASE; ANIMALS; CATALYSIS; HYDROGEN-ION CONCENTRATION; MICE; MUTATION; OXIMES; PYRIDINIUM COMPOUNDS; THIOCHOLINE;

EID: 28744439173     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.10.069     Document Type: Conference Paper

References (6)

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2. Z. Kovarik, Z. Radić, H.A. Berman, V. Simeon-Rudolf, E. Reiner, and P. Taylor Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates Biochem. J. 373 2003 33 40
3. L. Wong, Z. Radić, R.J.M. Brüggemann, N. Hosea, H.A. Berman, and P. Taylor Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis Biochemistry 39 2000 5750 5757
4. Z. Kovarik, Z. Radić, H.A. Berman, V. Simeon-Rudolf, E. Reiner, and P. Taylor Mutant cholinesterases possesing enchanced capacity for reactivation of their phosphonylated conjugates Biochemistry 43 2004 3222 3229
5. G.L. Ellman, K.D. Courtney, V. Andres Jr., and R.M. Featherstone A new and rapid colorimetric determination of acetylcholinesterase activity Biochem. Pharmacol. 7 1961 88 95
6. Y. Ashani, Z. Radić, I. Tsigelny, D.C. Vellom, N.A. Pickering, D.M. Quinn, B.P. Doctor, and P. Taylor Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes J. Biol. Chem. 270 1995 6370 6380