Press chamber coating as external lubrication for high speed rotary presses: Lubricant spray rate optimization

Drug Development and Industrial Pharmacy

Volumn 31, Issue 10, 2005, Pages 951-957

  Jahn, T ^a   Steffens, K J ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

External lubrication; Lubricant concentration; Magnesium stearate; PKB; Press chamber coating; Rotary tablet press; Tablet lubrication

Indexed keywords

LUBRICATING AGENT; MAGNESIUM STEARATE;

ARTICLE; CORRELATION ANALYSIS; LUBRICATION; MATERIAL COATING; TABLET; TENSILE STRENGTH;

CALIBRATION; DRUG COMPOUNDING; EQUIPMENT DESIGN; EXCIPIENTS; LACTOSE; LUBRICATION; MANNITOL; SORBITOL; SPECTROPHOTOMETRY, ATOMIC; STARCH; STEARIC ACIDS; TABLETS; TENSILE STRENGTH;

EID: 28744436975     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040500306161     Document Type: Article

References (30)

1. Al Shammat, M., Travers, D. N., & Buttery, T. C. (1979). Die wall reaction and friction during compaction of some direct compression base. Journal of Pharmacy and Pharmacology, 31, 76.
2. Bolhuis, G. K., & Lerk, C. F. (1973). Comparitive evaluation of excipients for direct compression. Pharmaceutisch Weekblad, 108, 469-481.
3. Bolhuis, G. K., & Lerk, C. F. (1977). Film forming of tablet lubricants during mixing process of solids. Acta Pharmaceutica Technologica, 23, 13-20.
4. Bolhuis, G. K., Lerk, C. F., Zijlstra, H. T., & De Boer, A. H. (1975). Film formation by magnesium stearate during mixing and its effect on tabletting. Pharmaceutisch Weekblad, 110, 317-325.
5. Bolhuis, G. K., Lerk, C. F., & Broersma, P. (1980). Mixing action and evaluation of tablet lubricants in direct compression. Drug Development and Industrial Pharmacy, 6, 15-33.
6. De Boer, A. H., Bolhuis, G. K., & Lerk, C. F. (1978). Bonding characteristics by scanning electron microscopy of powders mixed with magnesium stearate. Powder Technology, 20, 75-82.
7. Fell, J. T., & Newton, J. M. (1970). Determination of tablet strength by the diametrical compression test. Journal of Pharmaceutical Sciences, 59, 688-691.
8. Führer, C., Hanssen, D., & Schäfer, B. (1970a). Messung und Interpretation von Rest- und Ausstoßkräften bei der Tablettierung. Pharmazeutische Industrie, 32(1), 17-21.
9. Führer, C., Hanssen, D., & Schäfer, B. (1970b). Beurteilung von Magnesiumstearat als Tablettengleitmittel durch elektronische Druckmessung. Pharmazeutische Industrie, 32(2), 97-101.
10. Gruber, P., Gläsel, V. I., Klingelhöller, W., & Liske, T. (1988). Preßkammerbeschichtung, ein Beitrag zur Optimierung der Tablettenherstellung. Pharmazeutische Industrie, 50(7), 839-845.
11. Gullatz, A. (1996). Darstellung und Auswertung von Ausstoßkrä ften an Tablettenpressen. In: Dissertation. Germany: University of Bonn, 79-83.
12. Hinzpeter, J., Zeuschner, U., Olerags, H. J., & Lüneburg, P. (July 1, 1997). Method and Device for Depositing Pulverized Lubricants or Parting Compounds on the Pressing Rolls of Tableting Machines. U.S. Patent 5,643,630.
13. Jarosz, P. J., & Parrott, E. L. (1984). Effect of lubricants on tensile strengths of tablets. Drug Development and Industrial Pharmacy, 10, 259-273.
14. Lachman, L., Lieberman, H. E., & Kanig, J. L. (1976). Compaction and compression. In: The Theory and Practice of Industrial Pharmacy (2nd ed.). Philadelphia: Lea and Febiger, 306-307.
15. Laich, T., & Kissel, T. (1997). Experimentelle Charakterisierung der Preßkammerbeschichtung auf Rundlauftablettenpressen. Pharmazeutische Industrie, 59, 265-272.
16. Laich, T., & Kissel, T. (1998a). Untersuchung schmiermittelabhä ngiger Kenngrößen an einer Exzentertablettenpresse ausgerüstet mit einem externen Schmiersystem. Pharmazeutische Industrie, 60, 547-554.
17. Laich, T., & Kissel, T. (1998b). Automatische Anpassung der Schmiermittelmenge durch Regelung eines externen Schmiersystems. Pharmazeutische Industrie, 60, 896-904.
18. Lerk, C. F., Bolhuis, G. K., & Smedema, S. S. (1977). Interaction of lubricants and colloidal silica during mixing with excipients 1. Pharmaceutica Acta Helvetiae, 52, 33-38.
19. Miller, T. A., & York, P. (1988). Pharmaceutical tablet lubrication. International Journal of Pharmaceutics, 41, 1-19.
20. Mitrevej, K. T., & Augsburger, L. L. (1982). Adhesion of tablets in a rotary tablet press 2. Effects of blending time, running time and lubricant concentration. Drug Development and Industrial Pharmacy, 8, 237-282.
21. Mohrle, R. (1980). Effervescent tablet. In: H. A. Liebermann, L. Lachman (Eds.), Pharmaceutical Dosage Forms, Tablets. New York: Marcel Dekker, Inc., 225-257.
22. Moody, G., Rubinstein, M. H., & FitzSimmons, R. A. (1981). Tablet lubricants 1. Theory and modes of action. International Journal of Pharmaceutics, 9, 75-80.
23. Ragnarrson, G., Holzer, A. W., & Sjogren, J. (1979). The influence of mixing time and colloidal silica on the lubrication properties of magnesium stearate. International Journal of Pharmaceutics, 3, 127-131.
24. Riepma, K. A., Vromans, H., & Lerk, C. F. (1993). A coherent matrix model for the consolidation and compaction of an excipient with magnesium stearate. International Journal of Pharmaceutics, 97(1-3), 195-203.
25. Ritschel, W. A., & Bauer-Brandl, A. (2002). In: W. A. Ritschel (Ed.), Die Tablette (2nd ed.). Aulendorf, Germany: Editio Cantor, 324.
26. Schmidt, P. C., & Tenter, U. (1989). Preßkraft- und Weg-Zeit-Charakteristik von Rundlauftablettenpressen; 5. Mitt: Messung und Auswertung von Ausstoßkräften. Pharmazeutische Industrie, 51, 183-187.
27. Schrank-Junghäni, H., Bier, H. P., & Sucker, H. (1984). The measurement of die wall forces to determine the minimum concentration of lubricant needed for tablet formulations. Acta Pharmaceutica Technologica, 30(3), 224-234.
28. Shangraw, R. F. (1987). Compendial standards for pharmaceutical excipients. Drug Development and Industrial Pharmacy, 13, 2421-2439.
29. Stainforth, J. N., Cryer, S., Ahmed, H. A., & Davies, S. P. (1989). Aspects of pharmaceutical tribology. Drug Development and Industrial Pharmacy, 15(14-16), 2265-2294.
30. Varian (1989). Analytical Methods. Varian Techtron Pty Limited: Mulgrave Victoria, Australia, 37.