Syphilis: Uncommon presentations in adults

Clinics in Dermatology

Volumn 23, Issue 6, 2005, Pages 555-564

  Dourmishev, Lyubomir A ^a   Dourmishev, Assen L ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

[No Author keywords available]

Indexed keywords

PENICILLIN G;

ALOPECIA; ANEURYSM; ANOREXIA; AORTA VALVE REGURGITATION; ARTHRALGIA; ARTHRITIS; ARTICLE; BONE PAIN; CACHEXIA; CLINICAL FEATURE; CONDYLOMA; CONVALESCENCE; CRANIAL NERVE PARALYSIS; EYE DISEASE; FEVER; GASTRITIS; GLOMERULONEPHRITIS; HAIR LOSS; HEADACHE; HEARING IMPAIRMENT; HEPATITIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IRIDOCYCLITIS; JAUNDICE; KERATITIS; KIDNEY FAILURE; LYMPHADENOPATHY; MALAISE; MENINGITIS; MUCOSAL SECONDARY SYPHILIS; NAIL DISEASE; NAUSEA; NEPHROTIC SYNDROME; NEUROSYPHILIS; NONHUMAN; NYSTAGMUS; OPTIC NERVE DISEASE; OSTEITIS; PAPILLEDEMA; PAPILLITIS; PARESIS; PERCEPTION DEAFNESS; PRIORITY JOURNAL; PROPHYLAXIS; PROTEINURIA; PSORIASIS; PUSTULAR SYPHILIS; RASH; SCAR FORMATION; SKIN DISEASE; SYPHILIS; SYPHILIS MALIGNA; SYPHILITIC LEUKOMELANODERMA; SYPHILITIC ROSEOLA; TABES DORSALIS; TINNITUS; UVEITIS; VOMITING; WEIGHT REDUCTION;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PENICILLIN G; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SYPHILIS SERODIAGNOSIS; SYPHILIS, CUTANEOUS; SYPHILIS, LATENT; TABES DORSALIS; TREPONEMA PALLIDUM; UNITED STATES;

EID: 28644444875     PISSN: 0738081X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clindermatol.2005.01.015     Document Type: Article

References (107)

1. L. Doherty, K.A. Fenton, and J. Jones Syphilis: old problem, new strategy BMJ 325 2002 153 156
2. E. Weir, and D. Fishman Syphilis: have we dropped the ball? CMAJ 167 2002 1267 1268
3. D. Petzoldt Anstieg der syphilis in der Alpen-, Donau-, Moldauregion Hautarzt 47 1996 335
4. B. Swan, and N. Levine Syphilis eMedicine Dermatology 2001 [Journal serial online]. Available at: http://www.emedicine.com/derm/topic413.htm
5. A. Dourmishev Syphilis B. Iliev G. Mitov M. Radev Infectology 2001 Al Marin Drinov Sofia 818 823 [Article in Bulgarian]
6. L.M. Drusin Syphilis makes a comeback Int J STD AIDS 7 1996 7 10
7. G. Spirov Clinic and morphological characteristics of syphilis G. Spirov Syphilis 2000 ARSO Sofia 84 144 [Article in Bulgarian]
8. G. Spirov, and A. Dourmishev Syphilis A. Dourmishev Applied Venereology 2000 Znanie Sofia 13 24 [Article in Bulgarian]
9. P.M. Zorin Pathomorphosis of syphilis, its causes and genesis Vestn Dermatol Venerol 11 1974 29 35 [Article in Russian]
10. A. Dourmishev, and D. Njagolova Significance of donor blood for serological control of the epidemiology of syphilis in our country Dermatol Venereol (Sofia) 29 1991 43 49 [Article in Bulgarian]
11. A.E. Singh, and B. Romanowski Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features Clin Microbiol Rev 12 1999 187 209
12. I. Petkov Syphilis I. Petkov Practical Venereology 1968 Medicina i Fizkultura Sofia 12 50 [Article in Bulgarian]
13. T.A. Chapel The variability of syphilitic chancres Sex Transm Dis 5 1978 68 70
14. R.P. DiCarlo, and D.H. Martin The clinical diagnosis of genital ulcer disease in men Clin Infect Dis 25 1997 292 298
15. A. Mindel, S.J. Tovey, D.J. Timmins, and P. Williams Primary and secondary syphilis, 20 years' experience. 2. Clinical features Genitourin Med 65 1989 1 3
16. A. McMillan, and I.W. Smith Painful anal ulceration in homosexual men Br J Surg 71 1984 215 216
17. T.C. Quinn, L. Corey, and R.G. Chaffee The etiology of anorectal infections in homosexual men Am J Med 71 1981 395 406
18. S.E. Thompson, S.A. Larsen, and A.A. Moreland Syphilis S.A. Morse A.A. Moreland S.E. Thompson Atlas of sexually transmitted diseases 1 1990 Philadelphia Lippincott 1 19
19. U.F. Haustein, B. Pfeil, and A. Zschiesche Analyse der von 1983 1991 an der Universitäts-Hautklinik Leipzig beobachteten Syphilisfälle Hautarzt 44 1993 23 29
20. R.A. Gunn, T.A. Peterman, and K.A. Workowski Genital lesions of primary syphilis JAMA 291 2004 184
21. E. Peyri, J. Gomez, and O. Arango Fistula of the penile urethra caused by a phagedenic chancre Actas Urol Esp 8 1984 243 244 [Article in Spanish]
22. V.G. Koliadenko, D.I.a. Golovchenko, and S.V. Zaiko Phagedenic hard chancre Vestn Dermatol Venerol 10 1988 63 65 [Article in Russian]
23. A.C. Inamadar, and A. Palit Perforating chancre: any cause-effect relation with HIV infection? Sex Transm Infect 79 2003 262
24. G.G. Nureev, and V.I. Shaikhrazieva Case of a hypertrophied hard chancre Vestn Dermatol Venerol 9 1980 71 72 [Article in Russian]
25. T.R. Wade, and A. Huntley Multiple penile chancres. An atypical manifestation of primary syphilis Arch Dermatol 115 1979 227
26. J. Garcia-Silva, J.A. Velasco-Benito, and C. Pena-Penabad Primary syphilis with multiple chancres and porphyria cutanea tarda in an HIV-infected patient Dermatology 188 1994 163 165
27. J.C. English, R.A. Laws, and G.C. Keough Dermatoses of the glans penis and prepuce J Am Acad Dermatol 37 1997 1 24
28. K. Lejman, and Z. Starzycki Syphilitic balanitis of Follmann developing after the appearance of the primary chancre Br J Vener Dis 51 1975 138 140
29. T.A. Chapel The signs and symptoms of secondary syphilis Sex Transm Dis 7 1980 161 164
30. R.C. Adam, and L.B. Harkless Maculopapular rash in a 23-year-old patient J Am Podiatr Med Assoc 77 1987 500 502
31. W.R. Graham, and M. Duvic Nodular secondary syphilis Arch Dermatol 118 1982 205 206
32. S. Sapra, and L. Weatherhead Extensive nodular secondary syphilis Arch Dermatol 125 1989 1666 1669
33. M. Papini, A. Bettacchi, and A. Guiducci Nodular secondary syphilis Br J Dermatol 138 1998 704 705
34. S. Dave, D.V. Gopinath, and D.M. Thappa Nodular secondary syphilis Dermatol Online J 9 2003 9
35. J.L. Held, M. Ross, V. Beltrani Jr., S.R. Kohn, and M.E. Grossman Noduloulcerative or "malignant" syphilis occurring in an otherwise healthy woman: report and review of a dramatic dermatosis Cutis 45 1990 119 122
36. N. Noppakun, S.M. Dinehart, and A.R. Solomon Pustular secondary syphilis Int J Dermatol 26 1987 112 114
37. J.Y. Lee, and M.L. Hsu Alopecia syphilitica, a simulator of alopecia areata: Histopathology and differential diagnosis J Cutan Pathol 18 1991 87 92
38. E.E. Danielian, and M.S. Mokrousov Lesion of the nail plates in a patient with secondary fresh syphilis Vestn Dermatol Venerol 12 1979 59 61 [Article in Russian]
39. A. Dourmishev Disorders of skin pigmentation 1986 Medicina i Fizkultura Sofia 69 [Article in Bulgarian]
40. D. Harden, and J.H. Keeling Papular and nodular lesions of the scalp, face, and neck. Secondary syphilis Arch Dermatol 133 1997 1027 1030
41. I. Savova, E. Teodosieva, and H. Rueva Syphilis psoriasiformis et psoriasis vulgaris Dermatol Venereol (Sofia) 230 1981 180 181 [Article in Bulgarian]
42. Z. Penev, G. Karajashev, and S. Statkova Lues tertiaria perniformis et psoriasiformis Dermatol Venereol (Sofia) 27 1988 48 51 [Article in Bulgarian]
43. P. Sugathan Secondary syphilis and Sweet's syndrome Br J Dermatol 116 1987 879
44. H.F. Jordaan Secondary syphilis and Sweet's syndrome. Reply Br J Dermatol 116 1987 879 880
45. H.F. Jordaan, and J. Cilliers Secondary syphilis mimicking Sweet's syndrome Br J Dermatol 115 1986 495 496
46. D.L. Levin, N.B. Esterely, and J.J. Herman The Sweet syndrome in children J Pediatr 99 1981 73
47. L. Tappeiner, M. Moderer, A. Wollenberg, and H. Wolff Lues maligna ohne. Immunsuppression Akt Dermatol 28 2002 234 236
48. G. Spirov, A. Dourmishev, D. Njagolova, and K. Pramatarov Rarely observed form of syphilis-lues maligna Dermatol Venereol (Sofia) 22 1983 25 31 [Article in Bulgarian]
49. H. Pariser Precocious noduloulcerative cutaneous syphilis Arch Dermatol 111 1975 76 77
50. W.C. Lambert, M.P. Bagley, Y. Khan, and R.A. Schwartz Pustular acneiform secondary syphilis Cutis 37 1986 69 70
51. A. Bonev Frequency and localization of syphilic lesions in oral cavity Stomatology 3 1980 134 138 [Article in Bulgarian]
52. D. Golemanov, and G. Spirov Syphilitic laryngitis with condylomata lata of vocal fold Otorhinolaryngology 2 1979 69 73 [Article in Bulgarian]
53. C. Vibhagool, S.S. Raimer, and R.L. Sanchez A nodule on the lip. Nodular secondary syphilis Arch Dermatol 132 1996 822 826
54. S.Y. Lu, and H.L. Eng Secondary syphilis-related oral ulcers: report of four cases Chang Gung Med J 25 2002 683 688 [Article in Chinese]
55. A. Christen, H.E. Killer, B. Stamm, and P. Itin Secondary syphilis with ocular manifestations and oral ulceration Schweiz Rundsch Med Prax 92 2003 397 402 [Article in German]
56. C. Aquilina, R. Viraben, and P. Denis Secondary syphilis simulating oral hairy leukoplakia J Am Acad Dermatol 49 2003 749 751
57. R. Baran, R. Dawber, A. Tosti, and E. Haneke A text atlas of nail disorders 1996 Martin Dunitz London
58. J. Deschenes, C.D. Seamone, and M.G. Baines Acquired ocular syphilis: diagnosis and treatment Ann Ophthalmol 24 1992 134 138
59. C.E. Margo, and L.M. Hamed Ocular syphilis Surv Ophthalmol 37 1992 203 220
60. T.F. Schlaegel, and S.F. Kao A review (1970-1980) of 28 presumptive cases of syphilitic uveitis Am J Ophthalmol 93 1982 412 414
61. T.C. Spoor, P. Wynn, W.C. Hartel, and C.S. Bryan Ocular syphilis. Acute and chronic J Clin Neuro-ophthalmol 3 1983 197 203
62. M. Yokoi, and M. Kase Retinal vasculitis due to secondary syphilis Jpn J Ophthalmol 48 2004 65 67
63. M.R. Roque, and C.S. Foster Syphilis, ocular manifestations of eMedicine Ophthalmology 2003 [Journal serial online]. Available at: http://www.emedicine. com/
64. A. Morrison On syphilis and the ear-an otologist's view Genitourin Med 68 1992 420 422
65. E. Klemm, and U. Wollina Otosyphilis: report on six cases J Eur Acad Dermatol Venereol 18 2004 429 434
66. G. Spirov Visceral syphilis G. Spirov Syphilis 2000 ARSO Sofia 145 155 [Article in Bulgarian]
67. M.M. Smith, and J.C. Anderson Neurosyphilis as a cause of facial and vestibulocochlear nerve dysfunction: MR imaging features Am J Neuroradiol 21 2000 1673 1675
68. P. Corr, A. Bhigjee, and F. Lockhat Oculomotor nerve root enhancement in meningo vascular syphilis Clin Radiol 59 2004 294 296
69. A.J. Reginato Syphilitic arthritis and osteitis Rheum Dis Clin North Am 19 1993 379 398
70. M. Natale, I. Muras, F.A. Cioffi, and F.P. Bernini Syphilitic spinal arthropathy Acta Neurochir (Wien) 143 2001 1299 1300
71. D. Campisi, and C. Whitcomb Liver disease in early syphilis Arch Intern Med 139 1979 365 366
72. L.R. Petersen, R.H. Mead, and M.G. Perlroth Unusual manifestations of secondary syphilis occurring after orthotopic liver transplantation Am J Med 75 1983 166 170
73. D. Schlossberg Syphilitic hepatitis: a case report and review of the literature Am J Gastroenterol 82 1987 552 553
74. W. Hunte, F. al-Ghraoui, and R.J. Cohen Secondary syphilis and the nephrotic syndrome J Am Soc Nephrol 3 1993 1351 1355
75. G.B. Baudagna, V.C. de Miguel, and V. Greco Acute nephrotic syndrome associated with secondary syphilis Medicina (B Aires) 59 1999 277 278 [Article in Spanish]
76. H.R. Raz, V. Nickeleit, M.J. Mihatsch, and A. Colombi Patient with rapidly progressing renal failure, florid syphilis and positive HIV serology Schweiz Med Wochenschr 128 1998 1850 1856 [Article in German]
77. D.B. Greenstein, C.M. Wilcox, and D.A. Schwartz Gastric syphilis: report of seven cases and review of the literature J Clin Gastroenterol 18 1994 4 9
78. H.A. Winters, V. Notar-Francesco, and K. Bromberg Gastric syphilis: five recent cases and a review of the literature Ann Intern Med 116 1992 314 319
79. S. Olansky Late benign syphilis Med Clin North Am 48 1964 653 665
80. R.H. Kampmeier The late manifestations of syphilis: skeletal, visceral and cardiovascular Med Clin North Am 48 1964 667 697
81. E.G. Clark, and N. Danbolt The Oslo Study of the natural course of untreated syphilis. An epidemiologic investigation based on a re-study of the Boeck-Bruusgaard material Med Clin North Am 48 1964 613 623
82. G. Chung, G.R. Kantor, and S. Whipple Tertiary syphilis of the face J Am Acad Dermatol 24 1991 832 835
83. S.J. Wu, E.Q. Nguyen, T.A. Nielsen, and A.E. Pellegrini Nodular tertiary syphilis mimicking granuloma annulare J Am Acad Dermatol 42 2000 378 380
84. H.A. Heggtveit Syphilitic aortitis. A clinicopathologic autopsy study of 100 cases, 1950 to 1960 Circulation 29 1964 349 355
85. J.D. Jackman Jr., and J.D. Radolf Cardiovascular syphilis Am J Med 87 1989 425 433
86. S. Bojinov Syphilis of nervous system I. Petkov Practical venereology 1968 Medicina i Fizkultura Sofia 57 69 [Article in Bulgarian]
87. P. Shotekov Syphilis of central nervous system G. Spirov Syphilis 2000 ARSO Sofia 145 155 [Article in Bulgarian]
88. H. Hooshmand, M.R. Escobar, and S.W. Kopf Neurosyphilis. A study of 241 patients JAMA 219 1972 726 729
89. J.R. Hotson Modern neurosyphilis: a partially treated chronic meningitis West J Med 135 1981 191 200
90. S.A. Lukehart, E.W. Hook, and S.A. Baker-Zander Invasion of the central nervous system by Treponema pallidum: implications for diagnosis and treatment Ann Intern Med 109 1988 855 862
91. R.P. Simon Neurosyphilis Arch Neurol 42 1985 606 613
92. L.L. Bayne, J.W. Sidley, and D.S. Goodin Acute syphilitic meningitis: its occurrence after clinical and serologic cure of secondary syphilis with penicillin G Arch Neurol 43 1986 137
93. M.D. Holmes, M.M. Brant-Zawadzki, and R.P. Simon Clinical features of meningovascular syphilis Neurology 34 1984 553 556
94. I.E. Loewenfeld The Argyll Robertson pupil 1869-1969. A critical survey of the literature Surv Ophthalmol 14 1969 199 299
95. M. Goulon, J.C. Raphael, A.M. Chesneau, D. Brunel, and C. Lamer Surgically treated syphilitic gumma of the brain. Computerized tomography findings Rev Neurol (Paris) 142 1986 228 232 [Arcticle in French]
96. F.Y. Tsai, A.O. Schilp, and J.S. Leo Angiographic findings with an intracranial gumma Neuroradiology 13 1977 1 5
97. A. Kunicki, I. Goscinski, and J. Kaluza Two cases of cerebral gummata Neurol Neurochir Pol 4 1970 251 254 [Article in Polish]
98. S.C. Tucker, V.M. Yates, and I.V. Thambar Unusual skin ulceration in an HIV-positive patient who had cutaneous syphilis and neurosyphilis Br J Dermatol 136 1997 946 948
99. C.B. Hicks Syphilis and HIV infection W. James Dermatology Clinics vol 9 1991 WB Saunders Philadelphia 493 501
100. G. Ficarra, A.M. Zaragoza, and L. Stendardi Early oral presentation of lues maligna in a patient with HIV infection. A case report Oral Surg Oral Med Oral Pathol 75 1993 728 732
101. E.W. Hook Syphilis and HIV infection J Infect Dis 160 1989 530 534
102. N. Gregory, M. Sanchez, and M.R. Buchness The spectrum of syphilis in patients with human immunodeficiency virus infection J Am Acad Dermatol 22 1990 1061 1067
103. C.B. Hicks, P.M. Benson, and G.P. Lipton Seronegative secondary syphilis in a patient infected with human immunodeficiency virus (HIV) with Kaposi's sarcoma Ann Intern Med 107 1987 492 495
104. C.D. Berry, T.M. Hooton, A.C. Collier, and S.A. Lukehart Neurologic relapse after benzathine penicillin therapy for secondary syphilis in a patient with HIV infection N Engl J Med 316 1987 1587 1589
105. D.R. Johns, M. Tierney, and D. Felsenstein Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus N Engl J Med 316 1987 1569 1572
106. D.A. Katz, J.R. Berger, and R.C. Duncan Neurosyphilis. A comparative study of the effects of infection with human immunodeficiency virus Arch Neurol 50 1993 243 249
107. D.M. Musher, R.J. Hamill, and R.E. Baughn Effect of human immunodeficiency virus (HIV) infection on the course of syphilis and on the response to treatment Ann Intern Med 113 1990 872 881