Phenylalanine ammonia-lyase modified with polyethylene glycol: Potential therapeutic agent for phenylketonuria

Amino Acids

Volumn 29, Issue 3, 2005, Pages 283-287

  Ikeda, K ^a   Schiltz, E ^b   Fujii, T ^a   Takahashi, M ^a   Mitsui, K ^a   Kodera, Y ^a   Matsushima, A ^a   Inada, Y ^a   Schulz, G E ^b   Nishimura, H ^a,c  

^a TOIN UNIVERSITY OF YOKOHAMA   (Japan)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Department of Biomedical Engineering   (Japan)

Author keywords

Enzyme replacement therapy; Phenylalanine; Phenylalanine ammonia lyase; Phenylketonuria; Polyethylene glycol

Indexed keywords

2,4 BIS (O METHOXYPOLYETHYLENEGLYCOL) 6 CHLORO TRIAZINE; CINNAMIC ACID; MACROGOL; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; PHENYLALANINE AMMONIA LYASE; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANTIGENICITY; ARTICLE; CIRCULATION; DRUG CONJUGATION; DRUG STABILITY; ENZYME STABILITY; ENZYME THERAPY; FEMALE; MOUSE; NERVE CELL LESION; NONHUMAN; PARSLEY; PHENYLKETONURIA; PRIORITY JOURNAL;

ANIMALS; ENZYME ACTIVATION; FEMALE; MICE; MICE, INBRED BALB C; PETROSELINUM; PHENYLALANINE; PHENYLALANINE AMMONIA-LYASE; PHENYLKETONURIAS; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

ANIMALIA; PETROSELINUM CRISPUM;

EID: 28644437751     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-005-0218-5     Document Type: Article

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