The cytoplasmic tail of the α3 integrin subunit promotes neurite outgrowth in PC12 cells

Journal of Neuroscience Research

Volumn 82, Issue 6, 2005, Pages 753-761

  Mechai, Nadja ^a   Wenzel, Markus ^a   Koch, Manuel ^b   Lucka, Lothar ^a   Horstkorte, Rüdiger ^a   Reutter, Werner ^a   Danker, Kerstin ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Cytoplasmic tail; Integrin 3 1; Interleukin 2 receptor subunit; Rho kinase; RhoA

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CHIMERIC PROTEIN; COMPLEMENTARY DNA; INTERLEUKIN 2 RECEPTOR; KALININ; PROTEIN SUBUNIT; RECEPTOR SUBUNIT; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; VERY LATE ACTIVATION ANTIGEN 3; ANTIBODY; CELL ADHESION MOLECULE; ENZYME INHIBITOR; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL STRAIN; CYTOPLASM; CYTOSKELETON; ENZYME INHIBITION; GENE EXPRESSION; GENETIC TRANSFECTION; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; RAT; ANIMAL; BIOSYNTHESIS; CARCINOMA; CELL DIFFERENTIATION; COMPARATIVE STUDY; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; HUMAN; IMMUNOLOGY; METABOLISM; METHODOLOGY; NEURITE; PATHOLOGY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; BLOTTING, WESTERN; CARCINOMA; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELL LINE, TUMOR; CYTOPLASM; ENZYME INHIBITORS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; HUMANS; INTEGRIN ALPHA3BETA1; NEURITES; PC12 CELLS; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, INTERLEUKIN-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION;

EID: 28544449721     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20693     Document Type: Article

References (50)

1. Albelda SM, Buck CA. 1990. Integrins and other cell adhesion molecules. FASEB J 4:2868-2880.
2. Arthur WT, Petch LA, Burridge K. 2000. Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism. Curr Biol 10:719-722.
3. Bauer JS, Varner J, Schreiner C, Kornberg L, Nicholas R, Juliano RL. 1993. Functional role of the cytoplasmic domain of the integrin α5 subunit. J Cell Biol 122:209-221.
4. Berrier AL, Mastrangelo AM, Downward J, Ginsberg M, LaFlamme SE. 2000. Activated R-Ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains. J Cell Biol 151:1549-1560.
5. Berrier AL, Martinez R, Bokoch GM, LaFlamme SE. 2002. The integrin beta tail is required and sufficient to regulate adhesion signaling to Rac1. J Cell Sci 115:4285-4291.
6. Cary LA, Han DC, Guan JL. 1999. Integrin-mediated signal transduction pathways. Histol Histopathol 14:1001-1009.
7. FAK and the β1 integrin subunit are constitutively complexed in HaCaT cells. Exp Cell Res 239:326-331.
8. Danker K, Mechai N, Lucka L, Reutter W, Horstkorte R. 2001. The small GTPase ras is involved in growth factor-regulated expression of the alpha1 integrin subunit in PC12 cells. Biol Chem 382:969-972.
9. de Melker AA, Sterk LM, Delwel GO, Fles DL, Daams H, Weening JJ, Sonnenberg A. 1997. The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization. Lab Invest 76: 547-563.
10. DeFreitas MF, Yoshida CK, Frazier WA, Mendrick DL, Kypta RM, Reichardt LF. 1995. Identification of integrin alpha 3 beta 1 as a neuronal thrombospondin receptor mediating neurite outgrowth. Neuron 15:333-343.
11. DeMali KA, Wennerberg K, Burridge K. 2003. Integrin signaling to the actin cytoskeleton. Curr Opin Cell Biol 15:572-582.
12. Greene LA, Aletta JM, Rukenstein A, Green SH. 1987. PC12 pheochromocytoma cells: culture, nerve growth factor treatment, and experimental exploitation. Methods Enzymol 147:207-216.
13. Hall A. 1998. Rho GTPases and the actin cytoskeleton. Science 279:509-514.
14. Hayashi Y, Haimovich B, Reszka A, Boettiger D, Horwitz A. 1990. Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells. J Cell Biol 110:175-184.
15. Howe A, Aplin AE, Alahari SK, Juliano RL. 1998. Integrin signaling and cell growth control. Curr Opin Cell Biol 10:220-231.
16. Hughes PE, Pfaff M. 1998. Integrin affinity modulation. Trends Cell Biol 8:359-364.
17. Hughes PE, Diaz-Gonzales F, Leong L, Wu C, McDonald JA, Shattil SJ, Ginsberg MH. 1996. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J Biol Chem 271:6571-6574.
18. Hynes RO. 1987. Integrins: a family of cell surface receptors. Cell 48:549-554.
19. Ishii T, Satoh E, Nishimura M. 2001. Integrin-linked kinase controls neurite outgrowth in N1E-115 neuroblastoma cells. J Biol Chem 276: 42994-43003.
20. Ishizaki T, Uehata M, Tamechika I, Keel J, Nonomura K, Maekawa M, Narumiya S. 2000. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 57:976-983.
21. Kawaguchi S, Hemler ME. 1993. Role of the alpha subunit cytoplasmic domain in regulation of adhesive activity mediated by the integrin VLA-2. J Biol Chem 268:16279-16285.
22. Kreidberg JA, Donovan MJ, Goldstein SL, Rennke H, Shepherd K, Jones RC, Jaenisch R. 1996. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development 122:3537-3547.
23. LaFlamme SE, Akiyame SK, Yamada KM. 1992. Regulation of fibronectin receptor distribution. J Cell Biol 117:437-447.
24. Liu S, Ginsberg MH. 2000. Paxillin binding to a conserved sequence motif in the alpha 4 integrin cytoplasmic domain. J Biol Chem 275: 22736-22742.
25. Liu S, Calderwood DA, Ginsberg MH. 2000. Integrin cytoplasmic domain-binding proteins. J Cell Sci 113:3563-3571.
26. Löster K, Voigt S, Heidrich C, Hofmann W, Reutter W. 1994. Cell-collagen adhesion is inhibited by monoclonal antibody 33.4 against the rat alpha 1-integrin subunit. Exp Cell Res 212:155-160.
27. Marcantonio EE, Guan JL, Trevithick JE, Hynes RO. 1990. Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis. Cell Regul 1:597-604.
28. Mastrangelo AM, Homan SM, Humphries MJ, LaFlamme SE. 1999. Amino acid motifs required for isolated beta cytoplasmic domains to regulate "in trans" beta1 integrin conformation and function in cell attachment. J Cell Sci 112:217-229.
29. Mielenz D, Hapke S, Poschl E, von der Mark H, von der Mark KJ. 2001. The integrin alpha 7 cytoplasmic domain regulates cell migration, lamellipodia formation, and p130CAS/Crk coupling. J Biol Chem 276:13417-13426.
30. Müller MM, Singer BB, Öbrink B, Lucka L. 2005. Transmembrane CEACAM1 affects integrin-dependent signalling and regulates extracellular matrix protein-specific morphology and migration of endothelial cells. Blood 105:3925-3934.
31. Nikolic M. 2002. The role of Rho GTPases and associated kinases in regulating neurite outgrowth. Int J Biochem Cell Biol 34:731-745.
32. Nusser N, Gosmanova E, Zheng Y, Tigyi G. 2002. Nerve growth factor signals through TrkA, phosphatidylinositol 3-kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells. J Biol Chem 277:35840-35846.
33. Relvas JB, Setzu A, Baron W, Buttery PC, LaFlamme SE, Franklin RJ, ffrench-Constant C. 2001. Expression of dominant-negative and chimeric subunits reveals an essential role for beta1 integrin during myelination. Curr Biol 11:1039-1043.
34. Rheinwald JG, Beckett MA. 1981. Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultures from human squamous cell carcinomas. Cancer Res 41:1657-1663.
35. Rossino P, Gavazzi I, Timpl R, Aumailley M, Abbadini M, Giancotti F, Silengo L, Marchisio P, Tarone G. 1990. Nerve growth factor induces increased expression of a laminin-binding integrin in rat pheochromocytoma PC12 cells. Exp Cell Res 189:100-108.
36. Rousselle P, Lunstrum GP, Keene DR, Burgeson RE. 1991. Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. Cell Biol 114:567-576.
37. Sastry SK, Horwitz AF. 1996. Adhesion-growth factor interactions during differentiation: an integrated biological response. Dev Biol 180:455-467.
38. Schaller MD, Otey CA, Hildebrand JD, Parsons JT. 1995. Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J Cell Biol 130:1181-1187.
39. Smith BE, Bradshaw AD, Choi ES, Rouselle P, Wayner EA, Clegg DO. 1996. Human SY5Y neuroblastoma cell interactions with laminin isoforms: neurite outgrowth on laminin-5 is mediated by integrin alpha 3 beta 1. Cell Adhes Commun 3:451-462.
40. Solowska J, Guan JL, Marcantonio EE, Trevithick JE, Buck CA, Hynes RO. 1989. Expression of normal and mutant avian integrin subunits in rodent cells. J Cell Biol 109:853-861.
41. Sonnenberg A, Modderman PW, Hogervorst F. 1988. Laminin receptor on platelets is the integrin VLA-6. Nature 336:487-489.
42. Tomaselli KJ, Hall DE, Flier LA, Gehlsen KR, Turner DC, Carbonetto S, Reichardt LF. 1990. A neuronal cell line (PC12) expresses two beta 1-class integrins-alpha 1 beta 1 and alpha 3 beta 1-that recognize different neurite outgrowth-promoting domains in laminin. Neuron 5: 651-662.
43. Tomaselli KJ, Doherty P, Emmett CJ, Damsky CH, Walsh FS, Reichardt LF. 1993. Expression of beta 1 integrins in sensory neurons of the dorsal root ganglion and their functions in neurite outgrowth on two laminin isoforms. J Neurosci 13:4880-4888.
44. Vogelezang MG, Liu Z, Relvas JB, Raivich G, Scherer SS, ffrench-Constant C. 2001. Alpha4 integrin is expressed during peripheral nerve regeneration and enhances neurite outgrowth. J Neurosci 21:6732-6744.
45. Vossmeyer D, Kaufmann C, Löster K, Lucka L, Horstkorte R, Reutter W, Danker K. 2000. The cytoplasmic domain of the α1-integrin subunit influences stress fiber formation via the conserved GFFKR motif. Exp Cell Res 256:321-327.
46. Whittaker CA, DeSimone DW. 1993. Integrin alpha subunit mRNAs are differentially expressed in early Xenopus embryos. Development 117:1239-1249.
47. Wixler V, Laplantine E, Geerts D, Sonnenberg A, Petersohn D, Eckes B, Paulsson M, Aumailley M. 1999. Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains. FEBS Lett 445:351-355.
48. Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. 2000. The LIM-only protein DRAL/ FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. J Biol Chem 275: 33669-33678.
49. Zhang XA, Bontrager AL, Stipp CS, Kraeft SK, Bazzoni G, Chen LB, Hemler ME. 2001. Phosphorylation of a conserved integrin a3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement. Mol Biol Cell 12:351-365.
50. Zutter MM, Santoro SA, Wu JE, Wakatsuki T, Dickeson SK, Elson EL. 1999. Collagen receptor control of epithelial morphogenesis and cell cycle progression. Am J Pathol 155:927-940.