Randomized placebo-controlled trial of a flavonoid-rich plant extract-based cream in the treatment of rosacea

Journal of the European Academy of Dermatology and Venereology

Volumn 19, Issue 5, 2005, Pages 564-568

  Rigopoulos, D ^a,d   Kalogeromitros, D ^a   Gregoriou, S ^a   Pacouret, J M ^b   Koch, C ^b   Fisher, N ^c   Bachmann, K ^c   Brown, M ^c   Schwarz, E ^c   Camel, E ^d   Katsambas, A ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b IRIS Institut de Recherches et d'Innovations Scientifiques   (France)

^c IEC Company ^*

^d ANDREAS SYGROS HOSPITAL   (Greece)

Author keywords

Chrysanthellium indicum; Flavonoids; Microcirculation; Rosacea

Indexed keywords

CHRYSANTHELLUM INDICUM EXTRACT; FLAVONOID; PLACEBO; PLANT EXTRACT; RUTOSIDE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ROSACEA; SKIN SENSITIVITY; SKIN TOXICITY; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EMOLLIENTS; FEMALE; FLAVONOIDS; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PLANT EXTRACTS; PROBABILITY; REFERENCE VALUES; ROSACEA; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 28544446431     PISSN: 09269959     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2005.01248.x     Document Type: Article

References (13)

1. Dahl MV. Pathogenesis of rosacea. Adv Dermatol 2001; 17: 29-45.
2. Bamford JT. Rosacea: current thoughts on origin. Semin Cutan Med Surg 2001; 20: 199-206.
3. Szlachcic A. The link between helicobacter pylori infection and rosacea. J Eur Acad Dermatol Venereol 2002; 41: 768-770.
4. Georgala S, Katoulis AC, Kylafis GD et al. Increased density of Demodex follicularum and evidence of delayed hypersensitivity reaction in subjects with papulopostular rosacea. J Eur Acad Dermatol Venereol 2001; 15: 441-444.
5. McClellan KJ, Noble S. Topical metronidazole: a review of its use in rosacea. Am J Clin Dermatol 2000; 1: 191-199.
6. Rebora A. The management of rosacea. Am J Clin Dermatol 2002; 3: 489-496.
7. Del Rosso JQ. A status report on the medical management of rosacea: focus on topical therapies. Cutis 2002; 70: 271-275.
8. Tan JKL, Girard C, Krol A. Randomized placebo-controlled trial of metronidazole 1% cream with sunscreen SPF 15 in treatment of rosacea. J Cut Medical Surg 2002: 529-534.
9. Oztas MO, Balk M, Ogus E et al. The role of free-oxygen radicals in the aetiopathogenesis of rosacea. Clin Exp Dermatol 2003; 28: 188-192.
10. Honore-Thorez D. Description, identification and therapeutic use of Chrysanthellum 'americanum': Chrysanthellum indicum DC. subsp. afroamericanum B. L. Turner. J Pharm Belg 1985; 40: 323-331.
11. Cloarec M. Pharmacologie clinique et clinique d'un extrait de Chrysanthellum. CHU Hopital Saint-Antoine, Paris, 1982.
12. Merfort I. In vivo skin penetration studies of camomile flavones. Pharmazie 1994; 49: 509-511.
13. Draelos ZD. Cosmetics in acne and rosacea. Semin Cutan Med Surg 2001; 20: 209-214.