Neuropharmacokinetic characterization of lamotrigine after its acute administration to rats

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 27, Issue 8, 2005, Pages 539-545

  Castel Branco, M M ^a   Falcao A C ^a   Figueiredo, I V ^a   Caramona, M M ^a   Lanao, J M ^b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Brain; Lamotrigine; Pharmacokinetics; Plasma; Rats

Indexed keywords

LAMOTRIGINE;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BRAIN HOMOGENATE; BRAIN SIZE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; LINEAR SYSTEM; MALE; NONHUMAN; PARTITION COEFFICIENT; RAT; REACTION TIME; SINGLE DRUG DOSE; STATISTICAL MODEL;

ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; INJECTIONS, INTRAPERITONEAL; MALE; RATS; RATS, WISTAR; TIME FACTORS; TRIAZINES;

EID: 28444499339     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2005.27.8.928299     Document Type: Article

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