Preparation of Tc-99m-macroaggregated albumin from recombinant human albumin for lung perfusion imaging

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 62, Issue 1, 2006, Pages 26-31

  Hunt, A P ^a   Frier, M ^a   Johnson, R A ^b   Berezenko, S ^c   Perkins, A C ^a  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b Upperton Ltd   (United Kingdom)

^c Delta Biotechnology Ltd   (United Kingdom)

Author keywords

Diagnosis of pulmonary embolism; Lung imaging; Lung perfusion; Macroaggregates; Radiopharmaceutical; Recombinant albumin; Serum albumin

Indexed keywords

ACETIC ACID; BUFFER; HUMAN ALBUMIN; MACROSALB TC 99M; RADIOPHARMACEUTICAL AGENT; RECOMBINANT PROTEIN; STANNOUS CHLORIDE;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG RELEASE; DRUG STABILITY; FEMALE; IMAGING SYSTEM; ISOTOPE LABELING; LUNG PERFUSION; MOLECULAR STABILITY; NONHUMAN; PARTICLE SIZE; RABBIT; RADIOACTIVITY; RADIOCHEMISTRY;

ALBUMINS; ANIMALS; DRUG STABILITY; FEMALE; HUMANS; LUNG; PARTICLE SIZE; RABBITS; RADIOPHARMACEUTICALS; RECOMBINANT PROTEINS; TECHNETIUM TC 99M AGGREGATED ALBUMIN; TISSUE DISTRIBUTION;

EID: 28444499071     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.06.005     Document Type: Article

References (11)

1. M. Pistolesi, and M. Miniati Imaging techniques in treatment algorithms of pulmonary embolism Eur. Respir. J. Suppl. 35 2002 28s 39s
2. D.F. Worsley, and A. Alavi Radionuclide imaging of acute pulmonary embolism Semin. Nucl. Med. 33 2003 259 278
3. D.M. Asher Bovine sera used in the manufacture of biologicals: current concerns and policies of the US food and drug administration regarding the transmissible spongiform encephalopathies Dev. Biol. Stand. 99 1999 41 44
4. R. Bradley The research programme on transmissible spongiform encephalopathies in Britain with special reference to bovine spongiform encephalopathy Dev. Biol. Stand. 80 1993 157 170
5. A.C. Perkins, and M. Frier Bad blood and biologicals; the need for new radiopharmaceutical source materials Nucl. Med. Commun. 20 1999 1 3
6. A.V. Quirk, M.J. Geisow, J.R. Woodrow, S.J. Burton, P.C. Wood, A.D. Sutton, R.A. Johnson, and N. Dodsworth Production of recombinant human serum albumin from Saccharomyces cerevisiae Biotechnol. Appl. Biochem. 11 1989 273 287
7. N. Dodsworth, R. Harris, K. Denton, J. Woodrow, P.C. Wood, and A. Quirk Comparative studies of recombinant human albumin and human serum albumin derived by blood fractionation Biotechnol. Appl. Biochem 24 1996 171 176
8. 99mTc- recombinant human albumin (rHSA: a new generation of radiopharmaceutical) Eur. J. Nucl. Med. 21 1994 1231 1233
9. European Pharmacopeia fifth ed. European Directorate for the Quality of Medicines. Strasbourg, 2005.
10. M.J. Kruip, M.G. Leclercq, C. van der Heul, M.H. Prins, and H.R. Buller Diagnostic strategies for excluding pulmonary embolism in clinical outcome studies. A systematic review Ann. Intern. Med. 138 2003 941 951
11. C. Schumichen V/Q-scanning/SPECT for the diagnosis of pulmonary embolism Respiration 70 2003 329 342