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note
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The compounds were synthesized without complicated steps and were obtained in a high yield. Oligonucleotides containing the adenosine derivatives were synthesized on a solid support using phosphoramidite chemistry by automated DNA synthesis.
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-1, respectively), implying that the deoxyadenosine derivatives did not form a base pair with the opposing thymine.
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note
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Intercalation of the aromatic hydrocarbon group of X and the nucleotide base flipping for DNA duplexes were confirmed by thermodynamic parameters, CD spectra, gel electrophoresis, and fluorescence quenching experiments using 2-amino purine (manuscript in preparation).
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