The utility of EEG in dementia: A clinical perspective

International Journal of Geriatric Psychiatry

Volumn 20, Issue 11, 2005, Pages 1038-1045

  Adamis, Dimitrios ^a   Sahu, Sunita ^b   Treloar, Adrian ^b,c  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b OXLEAS NHS FOUNDATION TRUST   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Dementia; Electroencephalography; Psychiatric services; Review

Indexed keywords

CHOLINESTERASE INHIBITOR; DONEPEZIL; RIVASTIGMINE; TACRINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALPHA RHYTHM; ALZHEIMER DISEASE; BETA RHYTHM; BRAIN RADIOGRAPHY; COGNITIVE DEFECT; COMPUTER ASSISTED TOMOGRAPHY; CREUTZFELDT JAKOB DISEASE; DELTA RHYTHM; DEMENTIA; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFICACY; ELECTROENCEPHALOGRAM; FRONTOTEMPORAL DEMENTIA; HUMAN; HUNTINGTON CHOREA; IMAGE ANALYSIS; INFORMATION RETRIEVAL; INTERMETHOD COMPARISON; MEDICAL LITERATURE; MEDICAL SPECIALIST; MEDLINE; MULTIINFARCT DEMENTIA; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PREDICTION; QUANTITATIVE ANALYSIS; REVIEW; SYSTEMATIC REVIEW; THETA RHYTHM;

AIDS DEMENTIA COMPLEX; CHOLINESTERASE INHIBITORS; CREUTZFELDT-JAKOB SYNDROME; DEMENTIA; DIAGNOSIS, DIFFERENTIAL; ELECTROENCEPHALOGRAPHY; HUMANS; HUNTINGTON DISEASE; PARKINSON DISEASE; PROGNOSIS; TREATMENT OUTCOME;

EID: 28444480743     PISSN: 08856230     EISSN: None     Source Type: Journal    
DOI: 10.1002/gps.1393     Document Type: Review

References (98)

1. Adler G, Brassen S. 2001. Short-term rivastigmine treatment reduces EEG slow-wave power in Alzheimer patients. Neuropsychobiol 43: 273-276.
2. Adler G, Brassen S, Chwalek K, Dieter B, Teufel M. 2004. Prediction of treatment response to rivastigmine in Alzheimer's dementia. J Neurol Neurosurg Psychiatry 75: 292-294.
3. Adler G, Brassen S, Jajcevic A. 2003. EEG coherence in Alzheimer's dementia. J Neural Transm 110: 1051-1058.
4. Agnoli A, Martucci N, Manna V, Conti L, Fioravanti M. 1983. Effect of cholinergic and anticholinergic drugs on short-term memory in Alzheimer's dementia: a neuropsychological and computerized electroencephalographic study. Clin Neuropharmacol 6: 311-323.
5. Aguglia U, Gambardella A, Le Piane E, Messina D, Farnarier G, et al. 1997. Disappearance of periodic sharp wave complexes in Creutzfeldt-Jakob disease. Neurophysiol Clin 27: 277-282.
6. Alhainen K, Partanen J, Reinikainen K, Laulumaa V, Soininen H, et al. 1991. Discrimination of tetrahydroaminoacridine responders by a single dose pharmaco-EEG in patients with Alzheimer's disease. Neurosci Lett 127: 113-116.
7. Alhainen K, Riekkinen PJ, Sr. 1993. Discrimination of Alzheimer patients responding to cholinesterase inhibitor therapy. Acta Neurol Scand Suppl 149: 16-21.
8. Almkvist O, Jelic V, Amberla K, Hellstrom-Lindahl E, Meurling L, Nordberg A. 2001. Responder characteristics to a single oral dose of cholinesterase inhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients. Dement Geriatr Cogn Disord 12: 22-32.
9. Baldeweg T, Gruzelier JH. 1997. Alpha EEG activity and subcortical pathology in HIV infection. Int J Psychophysiol 26: 431-442.
10. Balkan S, Yaras N, Mihci E, Dora B, Agar A, Yargicoglu P. 2003. Effect of donepezil on EEG spectral analysis in Alzheimer's disease. Acta Neurol Belg 103: 164-169.
11. Barber PA, Varma AR, Lloyd JJ, Haworth B, Snowden JS, Neary D. 2000. The electroencephalogram in dementia with Lewy bodies. Acta Neurol Scand 101: 53-56.
12. Bennys E, Rondouin G, Vergnes C, Touchon J. 2001. Diagnostic value of quantitative EEG in Alzheimer's disease. Neurophysiol Clin 31: 153-160.
13. Berg L, Danziger WL, Storandt M, Coben LA, Gado M, et al. 1984. Predictive features in mild senile dementia of the Alzheimer type. Neurology 34: 563-569.
14. Brassen S, Adler G. 2003. Short-term effects of acetylcholinesterase inhibitor treatment on EEG and memory performance in Alzheimer patients: an open, controlled trial. Pharmacopsychiatry 36: 304-308.
15. Brenner RP, Ulrich RF, Spiker DG, Sclabassi RJ, Reynolds CF, 3rd, et al. 1986. Computerized EEG spectral analysis in elderly normal, demented and depressed subjects. Electroencephalogr Clin Neurophysiol 64: 483-492.
16. Brenner RP, Reynolds CF, 3rd, Ulrich RF. 1989. EEG findings in depressive pseudodementia and dementia with secondary depression. Electroencephalogr Clin Neurophysiol 72: 298-304.
17. Brenner RP. 1993. EEG and Dementia. In Electroencephalography: Basic Principles, Clinical Application, and Related Files, 3rd edn, Niedermeyer E, Lopes da Silva F (eds). Williams & Wilkins: Baltimore, MD; 339-349.
18. Briel RC, McKeith IG, Barker WA, Hewitt Y, Perry RH, et al. 1999. EEG findings in dementia with Lewy bodies and Alzheimer's disease. J Neurol Neurosurg Psychiatry 66: 401-403.
19. Calzetti S, Bortone E, Negrotti A, Zinno L, Mancia D. 2002. Frontal intermittent rhythmic delta activity (FIRDA) in patients with dementia with Lewy bodies: a diagnostic tool? Neurol Sci 23(Suppl. 2): S65-S66.
20. Cambier DM, Kantarci K, Worrell GA, Westmoreland BF, Aksamit AJ. 2003. Lateralized and focal clinical, EEG, and FLAIR MRI abnormalities in Creutzfeldt-Jakob disease. Clin Neurophysiol 114: 1724-1728.
21. Chan D, Walters RJ, Sampson EL, Schott JM, Smith SJ, Rossor MN. 2004. EEG abnormalities in frontotemporal lobar degeneration. Neurology 62: 1628-1630.
22. Chiaramonti R, Muscas GC, Paganini M, Muller TJ, Fallgatter AJ, et al. 1997. Correlations of topographical EEG features with clinical severity in mild and moderate dementia of Alzheimer type. Neuropsychobiol 36: 153-158.
23. Claus JJ, Kwa VI, Teunisse S, Walstra GJ, van Gool WA, et al. 1998a. Slowing on quantitative spectral EEG is a marker for rate of subsequent cognitive and functional decline in early Alzheimer disease. Alzheimer Dis Assoc Disord 12: 167-174.
24. Claus JJ, Ongerboer de Visser BW, Walstra GJ, Hijdra A, Verbeeten B, Jr., van Gool WA. 1998b. Quantitative spectral electroencephalography in predicting survival in patients with early Alzheimer disease. Arch Neurol 55: 1105-1111.
25. Claus JJ, Strijers RL, Jonkman EJ, Ongerboer de Visser BW, Jonker C, et al. 1999. The diagnostic value of electroencephalography in mild senile Alzheimer's disease. Clin Neurophysiol 110: 825-832.
26. Claus JJ, Ongerboer De Visser BW, Bour LJ, Walstra GJ, Hijdra A, et al. 2000. Determinants of quantitative spectral electroencephalography in early Alzheimer's disease: cognitive function, regional cerebral blood flow, and computed tomography. Dement Geriatr Cogn Disord 11: 81-89.
27. Coben LA, Danziger W, Storandt M. 1985. A longitudinal EEG study of mild senile dementia of Alzheimer type: changes at 1 year and at 2.5 years. Electroencephalogr Clin Neurophysiol 61: 101-112.
28. Comi GC, Fornara C, Locatelli T, et al. 1998. EEG coherence in Alzheimer's disease and multi-infarct dementia. Arch Gerontol Geriatr (Suppl. 6): 91-98.
29. Crystal HA, Dickson DW, Lizardi JE, Davies P, Wolfson LI. 1990. Antemortem diagnosis of diffuse Lewy body disease. Neurology 40: 1523-1528.
30. d'Onofrio F, Salvia S, Petretta V, Bonavita V, Rodriguez G, Tedeschi G. 1996. Quantified-EEG in normal aging and dementias. Acta Neurol Scand 93: 336-345.
31. Dunkin JJ, Osato S, Leuchter AF. 1995. Relationships between EEG coherence and neuropsychological tests in dementia. Clin Electroencephalogr 26: 47-59.
32. Edwards-Lee T, Cook I, Fairbanks L, Leuchter A, Cummings JL. 2000. Quantitative electroencephalographic correlates of psychosis in Alzheimer disease. Neuropsychiatry Neuropsychol Behav Neurol 13: 163-170.
33. Erkinjuntti T, Larsen T, Sulkava R, Ketonen L, Laaksonen R, Palo J. 1988. EEG in the differential diagnosis between Alzheimer's disease and vascular dementia. Acta Neurol Scand 77: 36-43.
34. Fletcher DJ, Raz J, Fein G. 1997. Intra-hemispheric alpha coherence decreases with increasing cognitive impairment in HIV patients. Electroencephalograp & Clin Neurophysiol 102: 286-294.
35. Fogelson N, Kogan E, Korczyn AD, Giladi N, Shabtai H, Neufeld MY. 2003. Effects of rivastigmine on the quantitative EEG in demented Parkinsonian patients. Acta Neurol Scand 107: 252-255.
36. Forstl H, Besthorn C, Hentschel F, Geiger-Kabisch C, Sattel H, Schreiter-Gasser U. 1996. Frontal lobe degeneration and Alzheimer's disease: a controlled study on clinical findings, volumetric brain changes and quantitative electroencephalography data. Dementia 7: 27-34.
37. Hansen HC, Zschocke S, Sturenburg HJ, Kunze K. 1998. Clinical changes and EEG patterns preceding the onset of periodic sharp wave complexes in Creutzfeldt-Jakob disease. Acta Neurol Scand 97: 99-106.
38. Helkala EL, Laulumaa V, Soininen H, Partanen J, Riekkinen PJ. 1991. Different patterns of cognitive decline related to normal or deteriorating EEG in a 3-year follow-up study of patients with Alzheimer's disease. Neurology 41: 528-532.
39. Hughes J. 1995. The EEG in psychiatry: an outline with summarized points and references. Clin Electroencephalograp 26: 92-101.
40. Hughes JR. 1996. A review of the usefulness of the standard EEG in psychiatry. Clin Electroencephalograp 27: 35-39.
41. Hughes JR, John ER. 1999. Conventional and Quantitative Electroencephalography in Psychiatry. J Neuropsychiatry Clin Neurosci 11: 190-208.
42. Ihl R, Brinkmeyer J, Janner M, Kerdar MS. 2000. A comparison of ADAS and EEG in the discrimination of patients with dementia of the Alzheimer type from healthy controls. Neuropsychobiol 41: 102-107.
43. Jelic V, Shigeta M, Julin P, Almkvist O, Winblad B, Wahlund LO. 1996. Quantitative electroencephalography power and coherence in Alzheimer's disease and mild cognitive impairment. Dementia 7: 314-323.
44. Jelic V, Julin P, Shigeta M, Nordberg A, Lannfelt L, et al. 1997. Apolipoprotein E epsilon4 allele decreases functional connectivity in Alzheimer's disease as measured by EEG coherence. J Neurol Neurosurg Psychiatry 63: 59-65.
45. Jelic V, Blomberg M, Dierks T, Basun H, Shigeta M, et al. 1998a. EEG slowing and cerebrospinal fluid tau levels in patients with cognitive decline. Neuroreport 9: 157-160.
46. Jelic V, Dierks T, Amberla K, Almkvist O, Winblad B, Nordberg A. 1998b. Longitudinal changes in quantitative EEG during long-term tacrine treatment of patients with Alzheimer's disease. Neurosci Lett 254: 85-88.
47. Jelic V, Johansson SE, Almkvist O, Shigeta M, Julin P, et al. 2000. Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer's disease. Neurobiol Aging 21: 533-540.
48. Jeong J, Chae JH, Kim SY, Han SH. 2001. Nonlinear dynamic analysis of the EEG in patients with Alzheimer's disease and vascular dementia. J Clin Neurophysiol 18: 58-67.
49. Knott V, Mohr E, Mahoney C, Ilivitsky V. 2000. Pharmaco-EEG test dose response predicts cholinesterase inhibitor treatment outcome in Alzheimer's disease. Methods Find Exp Clin Pharmacol 22: 115-122.
50. Kogan EA, Korczyn AD, Virchovsky RG, Klimovizky S, Treves TA, Neufeld MY. 2001. EEG changes during long-term treatment with donepezil in Alzheimer's disease patients. J Neural Transm 108: 1167-1173.
51. Kowalski JW, Gawel M, Pfeffer A, Barcikowska M. 2001. The diagnostic value of EEG in Alzheimer disease: correlation with the severity of mental impairment. J Clin Neurophysiol 18: 570-575.
52. Lehtovirta M, Partanen J, Kononen M, Hiltunen J, Helisalmi S, et al. 2000. A longitudinal quantitative EEG study of Alzheimer's disease: relation to apolipoprotein E polymorphism. Dement Geriatr Cogn Disord 11: 29-35.
53. Leocani L, Comi G. 1999. EEG coherence in pathological conditions. J Clin Neurophysiol 16: 548-555.
54. Leuchter AF, Spar JE, Walter DO, Weiner H. 1987. Electroencephalographic spectra and coherence in the diagnosis of Alzheimer's-type and multi-infarct dementia. A pilot study. Arch Gen Psychiatry 44: 993-998.
55. Leuchter AF, Newton TF, Cook IA, Walter DO, Rosenberg-Thompson S, Lachenbruch PA. 1992. Changes in brain functional connectivity in Alzheimer-type and multi-infarct dementia. Brain 115: 1543-1561.
56. Levy SR, Chiappa KH, Burke CJ, Young RR. 1986. Early evolution and incidence of electroencephalographic abnormalities in Creutzfeldt-Jakob disease. J Clin Neurophysiol 3: 1-21.
57. Lindau M, Jelic V, Johansson SE, Andersen C, Wahlund LO, Almkvist O. 2003. Quantitative EEG abnormalities and cognitive dysfunctions in frontotemporal dementia and Alzheimer's disease. Dement Geriatr Cogn Disord 15: 106-114.
58. Londos E, Passant U, Brun A, Rosen I, Risberg J, Gustafson L. 2003. Regional cerebral blood flow and EEG in clinically diagnosed dementia with Lewy bodies and Alzheimer's disease. Arch Gerontol Geriatr 36: 231-245.
59. Lopez OL, Brenner RP, Becker JT, Ulrich RF, Boller F, DeKosky ST. 1997. EEG spectral abnormalities and psychosis as predictors of cognitive and functional decline in probable Alzheimer's disease. Neurology 48: 1521-1525.
60. Montplaisir J, Petit D, McNamara D, Gauthier S. 1996. Comparisons between SPECT and quantitative EEG measures of cortical impairment in mild to moderate Alzheimer's disease. Eur Neurol 36: 197-200.
61. Moretti DV, Babiloni C, Binetti G, Cassetta E, Dal Forno G, et al. 2004. Individual analysis of EEG frequency and band power in mild Alzheimer's disease. Clin Neurophysiol 115: 299-308.
62. Muller TJ, Thome J, Chiaramonti R, Dierks T, Maurer K, et al. 1997a. A comparison of qEEG and HMPAO-SPECT in relation to the clinical severity of Alzheimer's disease. Eur Arch Psychiatry Clin Neurosci 247: 259-263.
63. Muller HF, Engelsmann F, Nair NP, Robitaille Y. 1997b. Psychogeriatric clinical, electro-encephalographic and autopsy findings. Neuropsychobiol 35: 95-101.
64. Musha T, Asada T, Yamashita F, Kinoshita T, Chen Z, et al. 2002. A new EEG method for estimating cortical neuronal impairment that is sensitive to early stage Alzheimer's disease. Clin Neurophysiol 113: 1052-1058.
65. Newton TF, Leuchter AF, Walter DO, et al. 1994. Electroencephalographic coherence in acquired immune deficiency syndrome. Psychiatry Res 54: 1-11.
66. Nobili F, Copello F, Vitali P, Prastaro T, Carozzo S, et al. 1999. Timing of disease progression by quantitative EEG in Alzheimer's patients. J Clin Neurophysiol 16: 566-573.
67. Nuwer MR, Miller EN, Visscher BR, et al. 1992. Asymptomatic HIV infection does not cause EEG abnormalities: results from the Multicenter AIDS Cohort Study (MACS) Neurology 42(6): 1214-1219.
68. Onofrj M, Thomas A, Iacono D, Luciano AL, Di Iorio A. 2003. The effects of a cholinesterase inhibitor are prominent in patients with fluctuating cognition: a part 3 study of the main mechanism of cholinesterase inhibitors in dementia. Clin Neuropharmacol 26: 239-251.
69. Parisi A, Di Perri G, Strosselli M, Nappi G, Minoli L, Rondanelli EG. 1989. Usefulness of computerized electroencephalography in diagnosing, staging and monitoring AIDS-dementia complex. Aids 3: 209-213.
70. Penttila M, Partanen JV, Soininen H, Riekkinen PJ. 1985. Quantitative analysis of occipital EEG in different stages of Alzheimer's disease. Electroencephalogr Clin Neurophysiol 60: 1-6.
71. Pijnenburg YA, van der Made Y, van Cappellen, et al. 2004. EEG synchronization likelihood in mild cognitive impairment and Alzheimer's disease during a working memory task. Clin Neurophysiol 115: 1332-1339.
72. Pozzi D, Vazquez S, Petracchi M, Dancygier G, Garcia H, Starkstein S. 1996. Quantified electroencephalographic correlates of relative frontal or parietal hypoperfusion in dementia. J Neuropsychiatry Clin Neurosci 8: 26-32.
73. Prichep LS, John ER, Ferris SH, Reisberg B, Almas M, et al. 1994. Quantitative EEG correlates of cognitive deterioration in the elderly. Neurobiol Aging 15: 85-90.
74. Pucci E, Cacchió G, Angeloni R, et al. 1998. EEG spectral analysis in Alzheimer's disease and different degenerative dementias. Arch Gerontol Geriatr 26: 283-297.
75. Pucci E, Belardinelli N, Cacchio G, Signorino M, Angeleri F. 1999. EEG power spectrum differences in early and late onset forms of Alzheimer's disease. Clin Neurophysiol 110: 621-631.
76. Reeves RR, Struve EA, Patrick G. 2002. The effects of donepezil on quantitative EEG in patients with Alzheimer's disease. Clin Electroencephalogr 33: 93-96.
77. Robinson DJ, Merskey H, Blume WT, Fry R, Williamson PC, Hachinski VC. 1994. Electroencephalography as an aid in the exclusion of Alzheimer's disease. Arch Neurol 51: 280-284.
78. Rodriguez G, Nobili F, Rocca G, De Carli F, Gianelli MV, Rosadini G. 1998. Quantitative electroencephalography and regional cerebral blood flow: discriminant analysis between Alzheimer's patients and healthy controls. Dement Geriatr Cogn Disord 9: 274-283.
79. Rodriguez G, Copello F, Vitali P, Perego G, Nobili F. 1999a. EEG spectral profile to stage Alzheimer's disease. Clin Neurophysiol 110: 1831-1837.
80. Rodriguez G, Nobili F, Copello F, Vitali P, Gianelli MV, et al. 1999b. 99mTc-HMPAO regional cerebral blood flow and quantitative electroencephalography in Alzheimer's disease: a correlative study. J Nucl Med 40: 522-529.
81. Rodriguez G, Vitali P, De Leo C, De Carli F, Girtler N, Nobili F. 2002. Quantitative EEG changes in Alzheimer patients during long-term donepezil therapy. Neuropsychobiology 46: 49-56.
82. Rosen I. 1996. Electroencephalography as a diagnostic tool in dementia; a review. Acta Neurol Scand Suppl 168: 63-70.
83. Sato K, Kamiya S, Okawa M, Hozumi S, Hori H, Hishikawa Y. 1996. On the EEG component waves of multi-infarct dementia seniles. Int J Neurosci 86: 95-109.
84. Seal ECJ, Van Hintum CJA, Pierson JM, Helme RD. 1998. Quantitative electroencephalography, with serial subtraction and odour detection in the differentiation of Alzheimer's disease and vascular dementia Arch Gerontol Geriatri 27: 115-126.
85. Scott DF, Heathfield KW, Toone B, Margerison JH. 1972. The EEG in Huntington's chorea: a clinical and neuropahological study. J Neurol Neurosurg Psychiatry 35: 97-102.
86. Signorino M, Pucci E, Belardinelli N, Nolfe G, Angeleri F. 1995. EEG spectral analysis in vascular and Alzheimer dementia. Electroencephalogr Clin Neurophysiol 94: 313-325.
87. Stam CJ, van der Made Y, Pijnenburg YA, Scheltens P. 2003. EEG synchronization in mild cognitive impairment and Alzheimer's disease. Acta Neurol Scand 108: 90-96.
88. Steinhoff BJ, Racker S, Herrendorf G, Poser S, Grosche S, et al. 1996. Accuracy and reliability of periodic sharp wave complexes in Creutzfeldt-Jakob disease. Arch Neurol 53: 162-166.
89. Steinhoff BJ, Kropp S, Riedemann C, Eckardt KM, Herrendorf G, Poser S. 1998. [Elecroencephalographic charactistics of Creutzfeldt-Jakob disease and its differential diagnosis]. Fortschr Neurol Psychiatr 66: 357-365.
90. Stigsby B, Johannesson G, Ingvar DH. 1981. Regional EEG analysis and regional cerebral blood flow in Alzheimer's and Pick's diseases. Electroencephalogr Clin Neurophysiol 51: 537-547.
91. Streletz LJ, Reyes PF, Zalewska M, Katz L, Fariello RG. 1990. Computer analysis of EEG activity in dementia of the Alzheimer's type and Huntington's disease. Neurobiol Aging 11: 15-20.
92. Strijers RL, Scheltens P, Jonkman EJ, de Rijke W, Hooijer C, Jonker C. 1997. Diagnosing Alzheimer's disease in community-dwelling elderly: a comparison of EEG and MRI. Dement Geriatr Cogn Disord 8: 198-202.
93. Van Everbroeck B, Dobbeleir I, De Waele M, De Deyn P, Martin JJ, Cras P. 2004 Differential diagnosis of 201 possible Creutzfeldt-Jakob disease patients. J Neurol 251(3): 298-304.
94. Weiner H, Schuster DB. 1956. The electroencephalogram in dementia. Some preliminary observations and correlations. Electroencephalogr Clin Neurophysiol 8: 479-488.
95. Wszolek Z, Herkes GK, Lagerlund TD, Kokmen E. 1992. Comparison of EEG background frequency analysis, psychologic test scores, short test of mental status, and quantitative SPECT in dementia. J Geriatr Psychiatry Neurol 5: 22-30.
96. Wszolek ZK, Lagerlund TD, Steg RE, McManis PG. 1998. Clinical neurophysiologic findings in patients with rapidly progressive familial parkinsonism and dementia with pallido-ponto-nigral degeneration. Electroencephalogr Clin Neurophysiol 107: 213-222.
97. Yenor GG, Leuchter AF, Jenden D, Read SL, Cummings JL, Miller BL. 1996. Quantitative EEG in frontotemporal dementia. Clin Electroencephalogr 27: 61-68.
98. Yoshimura M, Isotani T, Yagyu T, Irisawa S, Yoshida T, et al. 2004. Global approach to multichannel electroencephalogram analysis for diagnosis and clinical evaluation in mild Alzheimer's disease. Neuropsychobiol 49: 163-166.