Characterization of a topologically aberrant plasmid population from pilot-scale production of clinical-grade DNA

Journal of Biotechnology

Volumn 121, Issue 1, 2006, Pages 1-12

  Weigl, Debra ^a   Molloy, Mike J ^b   Clayton, Tim M ^b,d   Griffith, Jack ^c   Smith, Clara R ^a,e   Steward, Terry ^b   Merrill, Barbara M ^a,f   DePrince, Randolph B ^a,g   Jone, Carl S ^b   Persmark, Magnus ^a,h  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d MERCK SERONO S A   (Switzerland)

^e Diosynth Biotechnology   (United States)

^f BAYER CORPORATION   (United States)

^g Invitrogen Corporation ^*  (United States)

^h Invitrogen Corp   (United States)

Author keywords

Characterization; DNA vaccine; Plasmid; Supercoiling; Topology

Indexed keywords

CELL CULTURE; CHARACTERIZATION; DNA; ELECTROPHORESIS; FERMENTATION; GELS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; TOPOLOGY; VACCINES;

DNA VACCINES; METABOLIC STRESS; PLASMIDS; SUPERCOILING;

CYTOLOGY;

PLASMID DNA;

AGAR GEL ELECTROPHORESIS; ARTICLE; CELL SEPARATION; CONTROLLED STUDY; DNA METHYLATION; DNA SUPERCOILING; ESCHERICHIA COLI; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA METHYLATION; DNA, SUPERHELICAL; MICROSCOPY, ELECTRON, TRANSMISSION; PLASMIDS; REFERENCE STANDARDS; ULTRAFILTRATION;

ESCHERICHIA COLI;

EID: 28444476690     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2005.06.019     Document Type: Article

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