Hyperoxic ventilation enables hemodilution beyond the critical myocardial hemoglobin concentration

European Journal of Medical Research

Volumn 10, Issue 11, 2005, Pages 462-468

  Meier, Jens ^a   Kemming, Gregor ^b   Meisner, Franz ^c   Pape, Andreas ^a   Habler, Oliver ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

Anemia; Anemia tolerance; Hemodilution; Hyperoxic hemodilution; Oxygen

Indexed keywords

HEMOGLOBIN; HETASTARCH; OXYGEN;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; ELECTROCARDIOGRAM; HEART FUNCTION; HEART HEMODYNAMICS; HEART MUSCLE ISCHEMIA; HEART MUSCLE OXYGEN CONSUMPTION; HEART OUTPUT; HEMODILUTION; HEMOGLOBIN DETERMINATION; HYPOXIA; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYGEN TISSUE LEVEL; OXYGEN TRANSPORT; ROOM VENTILATION; TISSUE OXYGENATION;

ANIMALS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; ELECTROCARDIOGRAPHY; HEMATOCRIT; HEMODILUTION; HEMODYNAMIC PROCESSES; HEMOGLOBINS; HETASTARCH; HYPEROXIA; MYOCARDIAL ISCHEMIA; MYOCARDIUM; OXYGEN; OXYGEN CONSUMPTION; PLASMA SUBSTITUTES; RESPIRATION, ARTIFICIAL; SUS SCROFA; VASCULAR RESISTANCE;

EID: 28444460809     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. 2 tension in local control of coronary blood flow. Am J Physiol 258: 1388-1394
2. Chapler C, Cain S, Stainsby W (1984) The effects of hyperoxia on oxygen uptake during acute anemia. Can J Physiol Pharmacol 62: 809-814
3. Clark L (1956) Monitor and control of blood and tissue oxygen tension. Trans Am Soc Artif Intern Org 2: 41-46
4. Duling B (1972) Microvascular responses to alterations in oxygen tension. Circ Res 31: 481-489
5. Glenny R, Bernard S, Brinkley M (1993) Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion. J Appl Physiol 74: 2585-97
6. Habler O, Messmer K (1997) The physiology of oxygen transport. Tranfus Sci 18: 425-435
7. Habler O, Kleen M, Hutter J, Podtschaske A, Tiede M, Kemming G, Welte M, Corso C, Batra S, Keipert P, Faithfull N, Messmer K (1998) Effects of hyperoxic ventilation on hemodilution-induced changes in anesthetized dogs. Transfusion 38: 135-144
8. Habler O, Kleen MS, Hutter JW, Podtschaske AH, Tiede M, Kemming GI, Welte MV, Corso CO, Batra S, Keipert PE, Faithfull NS, Messmer KF (1998) Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusions: Effects on tissue oxygenation during profound hemodilution in anesthetized dogs. Transfusion 38: 145-155
9. Harder D, Narayanan J, Birks E, Liard J, Imig J, Lombard J, Lange A, Roman R (1996) Identification of a putative microvascular oxygen sensor. Circ Res 79: 54-61
10. Holt J, Rhode E, Kines H (1968) Ventricular volumes and body weight in mammals. Am J Physiol 215: 704-715
11. 2 transport and tissue oxygenation. TATM 5: 523-529
12. Kemming G, Meisner F, Meier J, Tillmanns J, Thein E, Eriskat J, Habler O (2004) Hyperoxic ventilation at the critical hematocrit: Effects on myocardial perfusion and function. Acta Anaesthesiol Scand 48: 951-959
13. Kemming G, Meisner F, Kleen M, Meier J, Tillmanns J, Hutter J, Wojtczyk C, Packert K, Bottino D, Habler O (2003) Hyperoxic ventilation at the critical hematocrit. Resuscitation 56: 289-297
14. Kessler M, Höper J, Krumme BA (1976) Monitoring of tissue perfusion and cellular function. Anesthesiology 45: 184-197
15. Kuhr L.-P., Bein T, Schächinger U, Stumpf M, Bele S, Taeger K, Nerlich M (2003) Hb=1,1 g/dl: erfolgreiche Behandlung nach Polytrauma mit schwerem hämorrhagischen Schock. Unfallchirurg 106: 586-591
16. London MJ, Hollenberg M, Wong MG, Levenson L, Tubau JF, Browner W, Mangano DT (1988) Intraoperative myocardial ischaemia: Localisation by continuous 12-lead electrocardiography. Anesthesiology 69: 232-241
17. Lund N, Jorfeldt L, Lewis D, Ödman S (1980) Skeletal muscle oxygen pressure fields in artificially ventilated critically ill patients. Acta Anaesth Scand 24: 347-353
18. Meier J, Kemming G, Kisch-Wedel H, Wölkhammer S, Habler O (2004) Hyperoxic ventilation reduces 6-hour mortality at the critical hemoglobin concentration. Anesthesiology 100: 70-76
19. Meier J, Kemming G, Kisch-Wedel H, Blum J, Pape A, Habler O (2004) Hyperoxic ventilation reduces 6-hour mortality after partial fluid resuscitation from hemorrhagic shock. Shock 22: 240-247
20. Meier J, Pape A, Lauscher P, Zwißler B, Habler O (2005) Hyperoxia in lethal methemoglobinemia: effects on oxygen transport, tissue oxygenation and survival in pigs. Crit Care Med 33(7): 1582-1588
21. Meisner F, Kemming G, Habler O, Kleen M, Tillmanns J, Hutter J, Bottino D, Thein E, Meier J, Wojtczyk C, Pape A, Messmer K (2001) Diaspirin crosslinked hemoglobin enables extreme hemodilution beyond the critical hematocrit. Crit Care Med 29: 829-838
22. Messmer K, Sunder-Plassmann L, Klövekorn WP, Holper K (1972) Circulatory significance of hemodilution: Rheological changes and limitations. Adv Microcirc 4: 1-77.
23. Ng K, Chow L, Wang C, Yang Y, Liu K, Lee T (2000) Successful management of massive blood loss to extremely low hemoglobin in an elderly woman receiving spinal surgery. Acta Anaesthesiol Sin 38: 89-92.
24. Spahn D, Leone B, Reves J, Pasch T (1994) Cardiovascular and coronary physiology of acute isovolemic hemodilution: A review of nonoxygen-carrying and oxygen-carrying solutions. Anesth Analg 78: 1000-1021
25. Spahn D, van Brempt R, Theilmeier G, Reibold J, Welte M, Heinzerling H, Birck K, Keipert P, Messmer K, Heinzerling H, Birck K, Keipert P, Messmer K (1999) Perflubron emulsion delays blood transfusion in orthopedic surgery. European Perflubron Emulsion Study Group. Anesthesiology 91: 1195-1208
26. Thein E, Raab S, Harris A, Messmer K (2000) Automation of the use of fluorescent microspheres for the determination of blood flow. Com Meth Prog Biomed 61: 11-21
27. Thein E, Raab S, Harris A, Messmer K (2002) Comparison of regional blood flow values measured by radioactive and fluorescent microspheres. Eur Surg Res 34: 215-223
28. Viele M, Weiskopf R (1994) What can we learn about the need for transfusion from patients who refuse blood? The experience with Jehovah's Witness. Transfusion 34: 396-401.
29. Yamaguchi S, Shinohara M, Mishio M, Okuda Y, Kitajima T (2000) Two cases of extreme hemodilution caused by massive hemorrhage immediatly after start of operation. Masui 49: 391-395
30. Zander R, Bormann B (1996) Life without hemoglobin. Anaesthesiol Intensivmed Notfallmed Schmerzther 31: 492-494
31. Zollinger A, Hager P, Singer T, Friedl HP, Pasch T, Spahn DR (1997) Extreme hemodilution due to massive blood loss in tumor surgery. Anesthesiology 87: 985-987