Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes

General Physiology and Biophysics

Volumn 24, Issue 3, 2005, Pages 311-325

  Bebarova M ^a   Matejovic P ^a   Pasek M ^a   Simurdova M ^a   Šimurda, Jiří ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Action potential; Ajmaline; Concentration; Dependence; Ionic currents; Rat ventricular myocytes

Indexed keywords

AJMALINE; CALCIUM ION; POTASSIUM ION; SODIUM ION;

ANIMAL CELL; ANIMAL TISSUE; CALCIUM CURRENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DATA ANALYSIS; DRUG MECHANISM; DRUG SENSITIVITY; DRUG STRUCTURE; ELECTRIC POTENTIAL; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE STEADY POTENTIAL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART RIGHT VENTRICLE; IC 50; ION CURRENT; MALE; MEMBRANE CURRENT; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; RAT; REVIEW; ROOM TEMPERATURE; SODIUM CURRENT; VELOCITY; WHOLE CELL;

ACTION POTENTIALS; ADENOSINE TRIPHOSPHATE; AJMALINE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; HEART VENTRICLES; INHIBITORY CONCENTRATION 50; IONS; MALE; MODELS, CHEMICAL; MUSCLE CELLS; PATCH-CLAMP TECHNIQUES; POTASSIUM; RATS; RATS, WISTAR; SODIUM; TEMPERATURE; TIME FACTORS;

ANIMALIA;

EID: 28444454098     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (48)

1. Abraham S., Beatch G. N., MacLeod B. A., Walker M. J. (1989): Antiarrhythmic properties of tetrodotoxin against occlusion-induced arrhythmias in the rat: a novel approach to the study of the antiarrhythmic effects of ventricular sodium channel blockade. J. Phaxmacol. Exp. Ther. 251, 1166-1173
2. Ahmmed G. U., Hisatome I., Kurata Y., Makita N., Tanaka Y., Tanaka H., Okamura T., Sonoyama K., Furuse Y., Kato M., Yamamoto Y., Ogura K., Shimoyama M., Miake J., Sasaki N., Ogino, K., Igawa O., Yoshida A., Shigemasa C. (2002): Analysis of moricizine block of sodium current in isolated guinea-pig atrial myocytes. Atrioventricular difference of moricizine block. Vascul. Pharmacol. 38, 131-141
3. + currents in isolated adult rat ventriculax myocytes. J. Gen. Physiol. 97, 973-1011
4. Arribas F., Cosio F. G., Palacios J., Alonso M., Lopez-Gil M. (1986): Effects of intravenous ajmaline on atrial excitability and conduction in man. Eur. Heart. J. 7, 158-164
5. Bahníková M., Matejovič P., Pásek M., Šimurdová M., Šimurda J. (2002): Ajmaline-induced block of sodium current in rat ventricular myocytes. Scr. Med. (Brno) 75, 169-178
6. Bébarová M., Matejovič P., Pásek M., Šimurdová M., Šimurda J. (2005): Effect of ajmaline on transient outward current in rat ventricular myocytes. Gen. Physiol. Biophys. 24, 27-45
7. Bojorges R., Pastelin G., Sanchez-Perez S., Mendez R., Kabela E. (1975): The effects of ajmaline in experimental and clinical arrhythmias and their relation to some electrophysiological parameters of the heart. J. Pharmacol. Exp. Ther. 193, 182-193
8. Brugada J., Brugada P., Brugada R. (2000): Sudden death (VI). The Brugada syndrome and right myocardiopathies as a cause of sudden death. The differences and similarities. Rev. Esp. Cardiol. 53, 275-285, (in Spanish)
9. Chen X., Borggrefe M., Martinez-Rubio A., Hief C., Haverkamp W., Hindricks G., Breithardt G. (1994): Efficacy of ajmaline and propafenone in patients with accessory pathways: a prospective randomized study. J. Cardiovasc. Pharmacol. 24, 664-669
10. + channels in rabbit atrial and ventricular cardiomyocytes. Eur. J. Pharmacol. 373, 223-232
11. Clark R. B., Bouchard R. A., Salinas-Stefanon E., Sanchez-Chapula J., Giles W. R. (1993): Heterogeneity of action potential waveforms and potassium currents in rat ventricle. Cardiovasc. Res. 27, 1795-1799
12. Cubeddu L. X. (2003): QT prolongation and fatal arrhythmias: a review of clinical implications and effects of drugs. Am. J. Ther. 10, 452-457
13. Dagres N., Clague J. R., Kottkamp H., Breithardt G., Borggrefe M. (2000): Antidromic atrioventricular reentrant tachycardia mimicking ventricular tachycardia in the setting of previous myocardial infarction. Clin. Cardiol. 23, 63-65
14. Eckardt L., Kirchhof P., Johna R., Breithardt G., Borggrefe M., Haverkamp W. (1999): Transient local changes in right ventricular monophasic action potentials due to ajmaline in a patient with Brugada syndrome. J. Cardiovasc. Electrophysiol. 10, 1010-1015
15. Enomoto K., Imoto M., Nagashima R., Kaneko T., Maruyama T., Kaji Y., Tsuda Y., Kanaya S., Fujino, T., Niho Y. (1995): Effects of ajmaline on non-sodium ionic currents in guinea pig ventricular myocytes. Jpn. Heart. J. 36, 465-476
16. Grenadier E., Alpan G., Keidar S., Weiss D., Marmor A., Palant A. (1983): The efficacy of ajmaline in ventricular arrhythmias after failure of lidocaine therapy in the acute phase of myocardial infarction. Angiology 34, 204-214
17. ATP channels and myocardial preconditioning: an update. Am. J. Physiol. 285, H921-930
18. Haverkamp W., Monnig G., Kirchhof P., Eckardt L., Borggrefe M., Breithardt G. (2001): Torsades de pointes induced by ajmaline. Z. Kardiol. 90, 586-590
19. Heistracher P. (1964): Electrophysiological studies on the mechanism of action of an antifibrillation agent on the rate of rise of the action potential of Purkinje fibers. Pflügers. Arch. 279, 305-329
20. Heistracher P. (1971): Mechanism of action of antifibrillatory drugs. Naunyn Schmiedebergs Arch. Pharmakol. 269, 199-212
21. Hii J. T., Wyse D. G., Gillis A. M., Duff H. J., Solylo M. A., Mitchell L. B. (1992): Precordial QT interval dispersion as a marker of torsades de pointes. Disparate effects of class Ia antiarrhythmic drugs and amiodaron. Circulation 86, 1376-1382
22. Hohnloser S. H., Singh B. N. (1995): Proarrhythmia with class III antiarrhythmic drugs: definition, electrophysiologic mechanisms, incidence, predisposing factors, and clinical implications. J. Cardiovasc. Electrophysiol. 6, 920-936
23. Homma N., Tsujimoto G., Hashimoto K. (2001): Electrophysiologic effects of an antiarrhythmic agent, bidisomide, on sodium current in isolated rat ventricular myocytes: comparison with mexiletine and disopyramide. Jpn. J. Pharmacol. 86, 23-31
24. Ito M., Onodera S., Noshiro H., Odakura H., Yasuda S., Nagashima M., Shinoda S., Suzuki H. (1990): Effect of class Ia antiarrhythmic agents on fasciculoventricular fibers. J. Electrocardiol. 23, 323-329
25. Ju Y. K., Saint D. A., Gage P. W. (1992): Effects of lignocaine and quinidine on the persistent sodium current in rat ventricular myocytes. Br. J. Pharmacol. 107, 311-316
26. Kiesecker C., Zitron E., Lück S., Bloehs R., Scholz E. P., Kathöfer S., Thomas D., Kreye V. A., Katus H. A., Schoels W., Karle C. A., Kiehn J. (2004): Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action. Naunyn Schmiedebergs Arch. Pharmacol. 370, 423-435
27. Kolář F., Ošt'ádal B. (2004): Molecular mechanisms of cardiac protection by adaptation to chronic hypoxia. Physiol. Res. 53, S3-13
28. Körper S., Wink M., Fink R. (1998): Differential effects of alkaloids on sodium currents of isolated single skeletal muscle fibers. FEBS Lett 436, 251-255
29. Liebeswar G., Thaler E., Heistracher P. (1970): Kinetik der Erholung der Natrium-Kanäle von der blockierenden Wirkung von Antifibrillantien. Naunyn Schmiedebergs Arch. Pharmakol. 266, 392-393
30. + channels by flecainide: evidence from the analysis of disease-linked mutations. J. Gen. Physiol. 120, 39-51
31. Manz M., Mletzko R., Jung W., Luderitz B. (1992): Electrophysiological and haemodynamic effects of lidocaine and ajmaline in the management of sustained ventricular tachycardia. Eur. Heart. J. 13, 1123-1128
32. Manz M., Luderitz B. (1993): Supraventricular tachycardia and pre-excitation syndromes: pharmacological therapy. Eur. Heart. J. 14 (Suppl E), 91-98
33. Obayashi K., Mandel W. J. (1976): Electrophysiological effects of ajmaline in isolated cardiac tissue. Cardiovasc. Res. 10, 20-24
34. Padrini R., Piovan D., Javarnaro A., Cucchini F., Ferrari M. (1993): Pharmacokinetics and electrophysiological effects of intravenous ajmaline. Clin. Pharmacokinet. 25, 408-414
35. Roden D. M. (1993): Early after-depolarizations and torsades de pointes: implications for the control of cardiac arrhythmias by prolonging repolarization. Eur. Heart. J. 14 (Suppl H), 56-61
36. Roden D. M. (2003): Genetic polymorphisms, drugs, and proarrhythmia. J. Interv. Card. Electrophysiol. 9, 131-135
37. Rolf S., Haverkamp W., Borggrefe M., Mußhoff U., Eckardt L., Mergenthaler J., Snydersb D. J., Pongs O., Speckmann E. J., Breithardt G., Madeja M. (2000): Effects of antiarrhythmic drugs on cloned cardiac voltage-gated potassium channels expressed in Xenopus oocytes. Naunyn Schmiedebergs Arch. Pharmacol. 362, 22-31
38. Saint D. A., Ju Y. K., Gage P. W. (1992): A persistent sodium current in rat ventricular myocytes. J. Physiol. (London), 453, 219-231
39. + channels in Xenopus oocytes. Br. J. Pharmacol. 107, 1061-1067
40. + channel block by disopyramide. J. Pharmacol. Exp. Ther. 290, 515-523
41. + current in rat cardiac ventricular cells. J. Physiol. (London), 491, 81-97
42. Schrickel J., Bielik H., Yang A., Schwab J. O., Shlevkov N., Schimpf R., Luderitz B., Lewalter T. (2003): Amiodarone-associated "torsades de pointes". Relevance of concomitant cardiovascular medication in a patient with atrial fibrillation and structural heart disease. Z. Kardiol. 92, 889-892
43. Schuchert A., Meinertz T. (2000): Acute effects of a class IA antiarrhythmic drug on the ventricular evoked response amplitude in patients with cardiac pacemakers. Cardiology 94, 103-105
44. + currents in rat ventricular myocytes. Circ. Res. 74, 620-628
45. + channel blocking actions of flecainide compared with those of propafenone and quinidine in adult rat ventricular myocytes. J. Pharmacol. Exp. Ther. 269, 66-74
46. Šimurdová M., Bravený P. (1998): ATP-sensitive potassium channels and cardiac protection. Exp. Clin. Cardiol. 3, 3-9
47. Varro A., Lathrop D. A., Hester S. B., Nanasi P. P., Papp J. G. (1993): Ionic currents and action potentials in rabbit, rat, and guinea pig ventricular myocytes. Basic Res. Cardiol. 88, 93-102
48. + current in rat ventricle. Am. J. Physiol. 276, H1599-1607