Enantioselective pharmacokinetics of mabuterol in rats studied using sequential achiral and chiral HPLC

Biomedical Chromatography

Volumn 19, Issue 9, 2005, Pages 703-708

  Lu, Xiumei ^a   Liu, Pei ^a   Chen, Huashan ^a   Qin, Feng ^a   Li, Famei ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Chiral; Enantioselectivity; HLPC; Mabuterol; Pharmacokinetics

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; RATS;

CHIRAL; CHIRAL HPLC; CHROMATOGRAPHIC METHODS; ENANTIOSELECTIVE PHARMACOKINETICS; ENDOGENOUS SUBSTANCES; HLPC; MABUTEROL; ODS COLUMNS; ORAL DOSE; PLASMA SAMPLES;

ENANTIOMERS;

MABUTEROL;

ACCURACY; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CALIBRATION; CHIRAL CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; QUANTITATIVE ANALYSIS; RACEMIC MIXTURE; RAT; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; VALIDATION PROCESS;

ANIMALIA;

EID: 28444451470     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.584     Document Type: Article

References (14)

1. Aboul-Enein HY and Ali I. Chiral resolution of clenbuterol, cimaterol, and mabuterol on Chirobiotic V, T, and TAG columns. Journal of Separation Science 2002; 25: 851-855.
2. Brambilla G, Fiori M, Rizzo B, Crescenzi V and Masci G. Use of molecularly imprinted polymers in the solid-phase extraction of clenbuterol from animal feeds and biological matrices. Journal of Chromatography B 2001; 759: 27-32.
3. Chirobioc™ Handbook. Guide to Using Macrocyclic Glycopeptide Bonded Phases for Chiral LC Separations, 3rd edn. Advanced Separation Technologies, Whippany, NJ, USA, 1999, 18.
4. Guentert TW, Buskin JN and Galeazzi RL. Single dose pharmacokinetics of mabuterol in man. Arzneimittelforschung 1984; 34: 1691-1696.
5. Kootstra PR, Kuijpers CJPF, Wubs KL, Doorn D, Sterk SS, Ginkel LA and Stephany RW. The analysis of beta-agonists in bovine muscle using molecular imprinted polymers with ion trap LCMS screening. Analytica Chimica Acta 2005; 529: 75-81.
6. 2-stimulant I: bronchodilating effect. Arzneimittelforschung 1984; 34: 1633-1640.
7. 2-stimulant. II: effects on the cardiovascular system and smooth muscle organs. Arzneimittelforschung 1984a; 34: 1641-1651.
8. 2-stimulant. III: effects on the central nervous system, striated muscle and carbohydrate and lipid metabolism. Arzneimittelforschung 1984b; 34:1652-1658.
9. Qureshi GA and Eriksson A. Determination of clenbuterol and mabuterol in equine plasma by ion-pair liquid chromatography with electrochemical detection. Chromatographic and electrochemical characteristics. Journal of Chromatography 1988; 441: 197-205.
10. 2-Adrenergic agonist residues: simultaneous methyl- and butylboronic derivatization for confirmatory analysis by gas chromatography-mass spectrometry. Journal of Chromatography B 1998; 716: 366-370.
11. Reig M, Battle N, Navarro JL and Toldrá F. Stability of β-agonist methyl boronic derivatives before gas chromatography-mass spectrometry analysis. Analytica Chimica Acta 2005; 529: 293-297
12. 2-adrenergic stimulant in the trachea. Journal of Immunoassay 1985; 6: 261-276.
13. You QD and Lin GQ. Chiral Drugs. Chemical Industry Press: Beijing, 2004; 27.
14. 2-stimulant. I: studies on the absorption, distribution and excretion in rats. Arzneimittelforschung 1984; 34: 1659-1667.