trans-4-(Aminomethyl)cyclohexane carboxylic acid methylamide (t-AMCHA methylamide) inhibits the physical interaction between urokinase-type plasminogen activator and stratum corneum, and accelerates the recovery of barrier function [5]

Journal of Dermatological Science

Volumn 40, Issue 3, 2005, Pages 218-220

  Katsuta, Yuji ^a   Yoshida, Yuzo ^a   Kawai, Eriko ^a   Suetsugu, Masaru ^a   Kohno, Yoshiyuki ^a   Inomata, Shinji ^a   Kitamura, Kenji ^a  

^a SHISEIDO RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (AMINOMETHYL)CYCLOHEXANE CARBOXYLIC ACID METHYLAMIDE; CARBOXYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL TISSUE; CONTROLLED STUDY; DRUG EFFECT; DRY SKIN; ENZYME ACTIVATION; ENZYME INHIBITION; GUINEA PIG; HUMAN; HUMAN TISSUE; LETTER; MALE; MOLECULAR WEIGHT; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STRATUM CORNEUM; SUNBURN; WATER LOSS;

ANIMALS; ANTIFIBRINOLYTIC AGENTS; RECOVERY OF FUNCTION; SKIN; TRANEXAMIC ACID; URINARY PLASMINOGEN ACTIVATOR;

EID: 28444435523     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2005.10.004     Document Type: Letter

References (5)

1. M. Denda, K. Kitamura, P.M. Elias, and K.R. Feingold trans-4- (Aminomethyl) cyclohexane carboxylic acid (T-AMCHA), an anti-fibrinolytic agent, accelerates barrier recovery and prevents the epidermal hyperplasia induced by epidermal injury in hairless mice and humans J Invest Dermatol 109 1997 84 90
2. Y. Katsuta, Y. Yoshida, E. Kawai, Y. Kohno, and K. Kitamura Urokinase-type plasminogen activator is activated in stratum corneum after barrier disruption J Dermatol Sci 32 2003 55 57
3. M. Denda, L.C. Wood, S. Emami, C. Calhoun, B.E. Brown, and P.M. Elias The epidermal hyperplasia associated with repeated barrier disruption by acetone treatment or tape stripping cannot be attributed to increased water loss Arch Dermatol Res 288 1996 230 238
4. M. Denda, J. Sato, T. Tsuchiya, P.M. Elias, and K.R. Feingold Low humidity stimulates epidermal DNA synthesis and amplifies the hyperproliferative response to barrier disruption: implication for seasonal exacerbations of inflammatory dermatoses J Invest Dermatol 111 1998 873 878
5. K. Kitamura, A. Ito, K. Yamada, Y. Yoshida, and M. Fukuda Potential medication for skin care - focusing on the development of a new effective compound for dry skin Skin Interface Living Syst 1998 151 166