Immunohistochemical analysis of p110RB expression in human cells and tissues: A reappraisal and critical review of the literature

Applied Immunohistochemistry and Molecular Morphology

Volumn 4, Issue 1, 1996, Pages 16-24

  Skelly, M ^a   Coltrera, M D ^a   Gown, A M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Heat induced epitope retrieval; Immunolocalization; Microwave oven; Nuclear immunostaining; p110RB

Indexed keywords

RETINOBLASTOMA PROTEIN;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROWAVE RADIATION; NORMAL HUMAN; PRIORITY JOURNAL; TECHNIQUE; TUMOR SUPPRESSOR GENE;

EID: 2842605030     PISSN: 10623345     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Tomasino RM, Morello V, Tralongo V, et al. p53 expression in human renal cell carcinoma: an immunohistochemical study and a literature outline of the cytogenetic characterization. Pathologica 1994;86:227-33.
2. Allred DC, O'Connell P, Fuqua SA, Osborne CK. Immunohistochemical studies of early breast cancer evolution. Breast Cancer Res Treat 1994;32:13-8.
3. Gorgoulis V, Rassidakis G, Karameris A, Giatromanolaki A, Barbatis C, Kittas C. Expression of p53 protein in laryngeal squamous cell carcinoma and dysplasia: possible correlation with human papillomavirus infection and clinicopathological findings. Virchows Arch 1994;425:481-9.
4. Rusch V, Klimstra D, Linkov I, Dmitrovsky E. Aberrant expression of p53 or the epidermal growth factor receptor is frequent in early bronchial neoplasia and coexpression precedes squamous cell carcinoma development. Cancer Res 1995;55:1365-72.
5. Tiniakos DG, Healicon RM, Hair T, Wadehra V, Horne CH, Angus B. p53 immunostaining as a marker of malignancy in cytologic preparations of body fluids. Acta Cytol 1995;39: 171-6.
6. Porter PL, Gown AM, Kramp SG, Coltrera MD. Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fixed, embedded tissue. Am J Pathol 1992;140:145-53.
7. Geradts J, Hu SX, Lincoln CE, Benedict WF, Xu HJ. Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti-RB antibodies. Int J Cancer 1994;58:161-7.
8. Xu HJ, Hu SX, Cagle PT, Moore GE, Benedict WF. Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas. Cancer Res 1991;51:2735-9.
9. Xu HJ, Cairns P, Hu SX, Knowles MA, Benedict WF. Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression. Int J Cancer 1993;53:781-4.
10. Wang J, Coltrera MD, Gown AM. Abnormalities of p53 and p110RB tumor suppressor gene expression in human soft tissue tumors: correlations with cell proliferation and tumor grade. Mod Pathol 1995;8:837-42.
11. Gown AM, Boyd HC, Chang Y, Ferguson M, Reichler B, Tippens D. Smooth muscle cells can express cytokeratins of "simple" epithelium. Immunocytochemical and biochemical studies in vitro and in vivo. Am J Pathol 1988;132:223-32.
12. Trifillis P, Picardi J, Alwine JC. Simian virus 40 T antigen can transcriptionally activate and mediate viral DNA replication in cells which lack the retinoblastoma susceptibility gene product. J Virol 1990;64:1345-7.
13. Wen SF, Nodelman M, Nared-Hood K, Duncan J, Geradts J, Shepard HM. Retinoblastoma protein monoclonal antibodies with novel characteristics. J Immunol Methods 1994; 169:231-40.
14. Levine AJ, Perry ME, Chang A, et al. The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis. Br J Cancer 1994;69:409-16.
15. Mateo MS, Sanchez-Beato M, Martinez JC, Orfao A, Orradre JL, Piris MA. p53, Rb and bcl-2 expression during the cell cycle: a study in phytohemagglutinin stimulated lymphocytes and microwave irradiated lymphoid sections. J Clin Pathol 1995;48:151-9.
16. Sawan A, Randall B, Angus B, et al. Retinoblastoma and p53 gene expression related to relapse and survival in human breast cancer: an immunohistochemical study. J Pathol 1992;168:23-8.
17. Trudel M, Mulligan L, Cavenee W, Margolese R, Cot'e J, Gari'epy G. Retinoblastoma and p53 gene product expression in breast carcinoma: immunohistochemical analysis and clinicopathologic correlation. Hum Pathol 1992;23:1388-94.
18. Ali AA, Marcus JN, Harvey JP, et al. RB1 protein in normal and malignant human colorectal tissue and colon cancer cell lines. FASEB J 1993;7:931-7.
19. Cordon-Cardo C, Richon VM. Expression of the retinoblastoma protein is regulated in normal human tissues. Am J Pathol 1994;144:500-10.
20. Constancia M, Seruca R, Carneiro F, Silva F, Castedo S. Retinoblastoma gene structure and product expression in human gastric carcinomas. Br J Cancer 1994;70:1018-24.
21. Xu HJ, Hu SX, Benedict WF. Lack of nuclear RB protein staining in G0/middle G1 cells: correlation to changes in total RB protein level. Oncogene 1991;6:1139-46.
22. Chen PL, Scully P, Shew JY, Wang JY, Lee WH. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 1989;58: 1193-8.
23. Kornblau SM, Xu HJ, Zhang et al. Levels of retinoblastoma protein expression in newly diagnosed acute myelogenous leukemia. Blood 1994;84:256-61.
24. Coppola JA, Lewis BA, Cole MD. Increased retinoblastoma gene expression is associated with late stages of differentiation in many different cell types. Oncogene 1990;5:1731-3.
25. Suzuki-Takahashi I, Kitagawa M, Saijo M, et al. The interactions of E2F and pRB and with p107 are regulated via the phosphorylation of pRB and p107 by a cyclin-dependent kinase. Oncogene 1995;10:1691-8.
26. van-Wijnen AJ, Aziz F, Grana X, et al. Transcription of histone H4, H3, and H1 cell cycle genes: promoter factor HiNF-D contains CDC2, cyclin A, and an RB-related protein. Proc Natl Acad Sci USA 1994;91:12882-6.
27. Smith EJ, Nevins JR. The Rb-related p107 protein can suppress E2F function independently of binding to cyclin A/cdk2. Mol Cell Biol 1995;15:338-44.
28. Kim YW, Otterson GA, Kratzke RA, Coxon AB, Kaye FJ. Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. Mol Cell Biol 1994;14:7256-64.
29. Cryns VL, Thor A, Xu HJ, et al. Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma [see comments]. N Engl J Med 1994;330:757-61.
30. Henson JW, Schnitker BL, Correa KM, et al. The retinoblastoma gene is involved in malignant progression of astrocytomas. Ann Neurol 1994;36:714-21.
31. Phillips SM, Barton CM, Lee SJ, et al. Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic lumorigenesis. Br J Cancer 1994;70: 1252-7.
32. Dodson MK, Cliby WA, Xu HJ, et al. Evidence of functional RB protein in epithelial ovarian carcinomas despite loss of heterozygosity at the RB locus. Cancer Res 1994;54:610-3.
33. Kim TM, Benedict WF, Xu HJ, et al. Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression. Cancer Res 1994;54:605-9.
34. Neubauer A, de-Kant E, Rochlitz C, et al. Altered expression of the retinoblastoma susceptibility gene in chronic lymphocytic leukaemia. Br J Haematol 1993;85:498-503.
35. Strohmeyer T, Reissmann P, Cordon-Cardo C, Hartmann M, Ackermann R, Slamon D. Correlation between retinoblastoma gene expression and differentiation in human testicular tumors. Proc Natl Acad Sci USA 1991;88:6662-6.
36. De-Chiara A, T'Ang A, Triche TJ. Expression of the retinoblastoma susceptibility gene in childhood rhabdomyosarcomas. J Natl Cancer Int 1993;85:152-7.
37. Logothetis CJ, Xu HJ, Ro JY, et al. Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer [see comments]. J Natl Cancer Inst 1992;84:1256-61.
38. Cordon-Cardo C, Wartinger D, Petrylak D, et al. Altered expression of the retinoblastoma gene product: prognostic indicator in bladder cancer [see comments]. J Natl Cancer Inst 1992;84:1251-6.
39. Bravo R, Macdonald-Bravo H. Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 1987; 105:1549-54.
40. Coltrera MD, Skelly M, Gown AM. Anti-PCNA antibody PC10 yields unreliable proliferation indices in routinely processed, deparaffinized, formalin fixed tissue. Appl Immunohistochem 1993;1:193-200.