Vascular aetiology of erectile dysfunction

International Journal of Andrology, Supplement

Volumn 28, Issue 2, 2005, Pages 35-39

  Francavilla, Sandro ^a   Bocchio, M ^a   Pelliccione, F ^a   Necozione, S ^a   Francavilla, F ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Atherosclerosis; Cardiovascular risk; Carotid arteries; Endothelium; Erectile dysfunction

Indexed keywords

ANGIOGRAPHY; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CARDIOVASCULAR RISK; CELL ACTIVATION; CONFERENCE PAPER; CORONARY ARTERY DISEASE; ENDOTHELIUM CELL; ERECTILE DYSFUNCTION; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR; VASCULAR DISEASE; VASCULAR ENDOTHELIUM;

EID: 28344440430     PISSN: 13504908     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2005.00584.x     Document Type: Conference Paper

References (39)

1. Andersen, T. J., Gerhard, M. D., Meredith, I. T., Charbonneau, F., Delagrange, D., Creager, M. A., Selwyn, A. P. & Ganz, P. (1995) Systemic nature of endothelial dysfunction in atherosclerosis. American Journal of Cardiology 75,71B-74B.
2. Bocchio, M., Desideri, G., Scarpelli, P., Necozione, S., Properzi, G., Spartera, C., Francavilla, F., Ferri, C & Francavilla, S. (2004) Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage. Journal of Urology 171,1601-1604.
3. Bocchio, M., Scarpelli, P., Necozione, S., Pelliccione, F., Mhialca, R., Spartera, C., Francavilla, F. & Francavilla, S. (2005) Intimamedia thickening of common carotid arteries is a risk factor for severe erectile dysfunction in men with vascular risk factors but no clinical evidence of atherosclerosis. Journal of Urology, 173, 526-29.
4. Burchardt, M., Burchardt, T., Baer, L., Kiss, A. J., Pawar, R. V., Shabsigh, A., de la Taille, A., Hayek, O. R. & Shabsigh, R. (2000) Hypertension is associated with severe erectile dysfunction. Journal of Urology 164,1188-1191.
5. Burke, G. L., Evans, G. W., Riley, W. A., Sharrett, A. R., Howard, G., Barnes, R. W., Rosamond, W., Crow, R. S., Rautaharju, P. M. & Heiss, G. (1995) Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. The Atherosclerotic Risk in Communities (ARIC) Study. Stroke 26,386-391.
6. Celermajer, D. S., Sorensen, K. E., Bull, C., Robinson, J. & Deanfield, J. E. (1994) Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. Journal of American College of Cardiology, 24,1468-1474.
7. De Angelis, L., Martella, M. A., Siniscalchi, M., Marino, L., Nappo, F., Giugliano, F., De Lucia, D. & Giugliano, D. (2001) Erectile and endothelial dysfunction in type II diabetes: a possible link. Diabetologia 44,1155-1160.
8. Fasching, P., Waldhausl, W. & Wagner, O. F. (1996) Elevated circulating adhesion molecules in NIDDM: potential mediators in diabetic macroangiopathy. Diabetologia 39,1242-1244.
9. Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J. & McKinlay, J. B. (1994) Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. Journal of Urology 151,54-61.
10. Feldman, H. A., Johannes, C. B., Derby, C. A., Klemman, K. P., Mohr, B. A. & Araujo, A. B. (2000) Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts Male Aging Study. Preventive Medicine 30,328-338.
11. Ferri, C., Carlomagno, A, Coassin, S., Baldoncini, R, Cassone Faldetta, M. R., Laurenti, O., Properzi, G., Santucci, A. & De Mattia, G. (1995) Circulating endothelin-1 levels increase during euglycemic hyperinsulinemic clamp in lean MIDDM men. Diabetes Care 18,226-333.
12. Ferri, C., Desideri, G., Balconcini, R., Bellini, C., De Angelis, C., Mazzocchi, C. & Santucci, A. (1998) Early activation of vascular endothelium in nonobese, nondiabetic essential hypertensive patients with multiple metabolic abnormalities. Diabetes 47, 660-667.
13. Francavilla, S., Properzi, G., Bellini, C., Marino, G., Ferri, C. & Santucci, A. (1997) Endothelin-1 in diabetic and nondiabetic men with erectile dysfunction. Journal of Urology 158,1770-1774.
14. Ganz, P. & Vita, J. A. (2003) Testing endothelial vasomotor function. Nitric oxide, a multiple molecule. Circulation 108, 2049-2053.
15. Gazzaruso, C., Giordanetti, S., De Amici, E., Bertone, G., Falcone, C., Geroldi, D., Fratino, P., Solerte, S. B. & Garzaniti, A. (2004) Relationship between erectile dysfunction and silent myocardial ischemia in apparently uncomplicated type 2 diabetic patients. Circulation 110,22-26.
16. Gearing, A. J. H. & Newman, W. (1993) Circulating adhesion molecules in disease. Immunology Today 14,506-512.
17. Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D. & Wicker, P. A. (1998) Oral sildenafil in the treatment of erectile dysfunction. New England Journal of Medicine 338,1397-1404.
18. Greenstem, A., Chen, J., Miller, H., Matzkin, H., Villa, Y. & Braf, Z. (1997) Does severity of ischemic coronary disease correlate with erectile function? International Journal of Impotence Research 9, 123-126.
19. Kaiser, D. R., Billups, K., Mason, C., Wetterling, R., Lundberg, J. L. & Bank, A. J. (2004) Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical carviovascular disease. Journal of American College of Cardiology 43,179-184.
20. Kim, N., Azadzoi, K. M., Goldstein, I. & Saenz de Tejada, I. (1991) A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. Journal of Clinical Investigation 88,112-118.
21. Kinsey, A. C., Pomeroy, W. & Martin, C. E. (1948) Age and Sexual Outlet. Sexual Behavior in the Human Man. WB Saunders, Philadelphia, PA,218-262.
22. Klein, R., Klein, B. E., Lee, K. E., Moss, S. E. & Cruickshanks, K. J. (1996) Prevalence of self reported erectile dysfunction in people with long-term IDDM. Diabetes Care 19,135-141.
23. Krane, R. J., Goldstein, I. & Saenz de Tejada, I. (1989) Impotence. New England Journal of Medicine 321,1648-1659.
24. Laumann, E. O., Paik, A. & Rosen, R. C. (1999) Sexual dysfunction in the United States: prevalence and predictors. The Journal of American Medical Association 281,537-544.
25. Mogensen, C. E. (1984) Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. New England Journal of Medicine 310,356-360.
26. O'Leary, D. H., Polak, J. F., Kronmal, R. A., Kittner, S. J., Bond, M. G., Wolfson, S. K. Jr, Bommer, W., Price, T. R., Gardin, J. M. & Savage, P. J. (1992) Distribution and correlates of sonografically detected carotid artery disease in the Cardiovascular Health Study: the CHS Collaborative Research Group. Stroke 23,1752-1760.
27. Palmer, R. M. J., Ferrige, A. G. & Moncada, S. (1987) Nitric oxide release accounts for the biological activity of the endothelium-derived relaxing factor. Nature 327,524-526.
28. Quyyumi, A. A. (1998) Endothelial function in health and disease: new insights into the genesis of cardiovascular disease. American Journal of Medicine 105,32S-39S.
29. Raitakari, O. T., Seale, J. P. & Celermajer, D. S. (2001) Impaired vascular response to nitroglycerin in subjects with coronary atherosclerosis. American Journal of Cardiology 87,217-219.
30. Ridker, P. M., Hennekens, C. H., Roitman-Johnson, B., Stampfer, M. J. & Allen, J. (1998) Plasma concentration of soluble intercellular adhesion molecule 1 and risk of future myocardial infarction in apparently healthy men. Lancet 351,88-92.
31. Romundstad, S., Holmen, J., Hallan, H., Kvenild, K. & Ellekjaer, H. (2003) Microalbuminuria and all-cause mortality in treated hypertensive individuals. Does sex matter? The Nord-Trondelag Health Study (HUNT), Norway. Circulation 108, 2783-2789.
32. Rosen, R. C., Cappelleri, J. C., Smith, M. D., Lipsky, J. & Pena, B. M. (1999) Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. International Journal of Impotence Reseach 11,318.
33. Saenz de Tejada, I., Goldstein, L, Azadzoi, K., Krane, L. J. & Cohen, R. A. (1989) Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. New England Journal of Medicine 320,1025-1030.
34. Salonen, J. & Salonen, R. (1991) Ultrasonographically assessed carotid morphology and the risk of coronary artery disease. Arteriosclerosis, Thrombosis and Vascular Biology 11,1245-1249.
35. Sharrett, A. R., Sorlie, P. D., Chambless, L. E., Folsom, A. R., Hutchinson, R. G., Heiss, G. & Szklo, M. (1999) Relative importance of various risk factors for asymptomatic carotid atherosclerosis versus coronary heart disease incidence: the Atherosclerotic Risk in Communities Study. American Journal of Epidemiology 149,843-852.
36. Solomon, H., Man, J., Wierzbicki, S. & Jackson, G. (2003) Relation of erectile dysfunction to angiographic coronary artery disease. American Journal of Cardiology 91,230-231.
37. Spoelstra-de Man, A. M., Brouwer, C. B., Stehouwer, C. D. & Smulders, Y. M. (2001) Rapid progression of albumin excretion is an independent predictor of cardiovascular mortality in patients with type 2 diabetes and microalbuminuria. Diabetes Care 24,2097-2101.
38. Sullivan, M. E., Thompson, C. S., Dashwood, M. R., Khan, M. A., Jeremy, J. Y., Morgan, R. J. & Mikhailidis, D. P. (1999) Nitric oxide and the penile erection: is the erectile dysfunction another manifestation of vascular disease? Cardiovascular Research 43,658-665.
39. Virag, R., Bouilly, P. & Frydman, D. (1985) Is impotence an arterial dysorder? A study of arterial risk factors in impotent men. Lancet 1,181-184.