Immune responses in Sprague-Dawley rats exposed to dibutyltin dichloride in drinking water as adults

Journal of Immunotoxicology

Volumn 2, Issue 3, 2005, Pages 151-160

  DeWitt, Jamie C ^a   Copeland, Carey B ^b   Luebke, Robert W ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIBUTYLTIN DICHLORIDE; DRINKING WATER; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; ORGANOTIN COMPOUND; POLYVINYLCHLORIDE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DOSE RESPONSE; FEMALE; FLUID INTAKE; IMMUNE FUNCTION TEST; IMMUNE RESPONSE; IMMUNOTOXICITY; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; OVIS ARIES;

EID: 28244468413     PISSN: 16602854     EISSN: 1547691X     Source Type: Journal    
DOI: 10.1080/15476910500276764     Document Type: Article

References (36)

1. DeSantiago, A., and Aguilar-Santelises, M. 1999. Organotin compounds decrease in vitro survival, proliferation and differentiation of normal human B lymphocytes. Human Exp. Toxicol. 18:619-624.
2. Forsyth, D. S., and Jay, B. 1997. Organotin leachates in drinking water from chlorinated poly(vinyl)chloride (CPVC) pipe. Appl. Organomet. Chem. 11:551-558.
3. 3H]-deltamethrin in Xenopus laevis oocytes. Toxicol. Lett. 157:79-88.
4. Miller, K., Scott, M. P., and Foster, J. R. 1983. Thymic involution in rats given diets containing dioctyltin dichloride. Clin. Immunol. Immunopharm. 30:62-70.
5. Mundy, W. R., Freudenrich, T. M., Crofton, K. M., and DeVito, M. J. 2004. Accumulation of PBDE-47 in primary cultures of rat neocortical cells. Toxicol. Sci. 82:164-169.
6. Penninks, A. H., and Seinen, W. 1984. Mechanisms of dialkyltin induced immunopathology. Vet. Quart. 6:209-215.
7. Penninks, A. H., Kuper, F., Spit, B. J., and Seinen, W. 1985. On the mechanism of dialkyltin-induced thymus involution. Immunopharmacology 10:1-10.
8. Pieters, R. H., Albers, R., Bleumink, R., Snoeij, N. J., Itoh, T., Seinen, W., and Penninks, A. H. 1995a. The thymus atrophy-inducing organotin compound DBTC inhibits the binding of thymocytes to thymic epithelial cells. Int. J. Immunopharmacol. 17:329-337.
9. Pieters, R. H., Kampinga, J., Snoeij, N. J., Bol-Schoenmakers, M., Lam, A. W., Penninks, A. H., and Seinen, W. 1989a. An immunohistochemical study of dibutyltin-induced thymus atrophy. Arch. Toxicol. Suppl. 13:175-178.
10. + immature thymocytes. Thymus 14:79-88.
11. Pieters, R. H., Punt, P., Bol, M., Van Dijken, J. M., Seinen, W., and Penninks, A. H. 1995b. The thymus atrophy inducing organotin compound DBTC stimulates TcR αβ-CD3 signaling in immature rat thymocytes. Biochem. Biophys. Res. Commun. 214:552-558.
12. Pieters, R. H., Bol, M., Seinen, W., and Penninks, A. H. 1994. Cellular and molecular aspects of organotin-induced thymus atrophy. Human Exp. Toxicol. 13:876-879.
13. Rooney, A. A., Matulka, R. A., and Luebke, R. W. 2003. Developmental atrazine exposure suppresses immune function in male, but not female Sprague-Dawley rats. Toxicol. Sci. 76:366-375.
14. Sadiki, A., and Williams, D. T. 1999. A study on organotin levels in Canadian drinking water distributed through PVC pipes. Chemosphere 38:1541-1548.
15. Sadiki, A., Williams, D. T., Carrier, R., and Thomas, B. 1996. Pilot study on the contamination of drinking water by organotin compounds from PVC materials. Chemosphere 32:2389-2398.
16. Seinen, W 1980. Immunosuppression induced by certain organotin compounds. Vet. Sci. Commun. 3:279-287.
17. Seinen, W., and Penninks, A. 1979. Immune suppression as a consequence of a selective cytotoxic activity of certain organometallic compounds on the tymus and thymus-dependent lymphocytes. Annals of the New York Academy of Sciences 320:466-517.
18. Seinen, W., and Willems, M. I. 1976. Toxicity of organotin compounds. I. Atrophy of thymus and thymus-dependent lymphoid tissue in rats fed di-n-octyltindichloride. Toxicol. Appl. Pharmacol. 35:63-75.
19. Seinen, W., Vos, J. G., Van Krieken, R., Penninks, A., Brands, R., and Hooykaas, H. 1977a. Toxicity of organotin compounds. III. Suppression of thymus-dependent immunity in rats by di-n-butyltindichloride and di-n-octyltindichloride. Toxicol. Appl. Pharmacol. 42:213-224.
20. Seinen, W., Vos, J. G., Van Spanje, I., Snoek, M., Brands, R., and Hooykaas, H. 1977b. Toxicity of organotin compounds. II. Comparative in vivo and in vitro studies with various organotin and organolead compounds in different animal species with special emphasis on lymphocyte cytotoxicity. Toxicol. Appl. Pharmacol. 42:197-212.
21. Smialowicz, R. J., Riddle, M. M., Rogers, R. R., Luebke, R. W., and Copeland C. B. 1989. Immunotoxicity of tributyltin oxide in rats exposed as adults or pre-weanlings. Toxicology 57:97-111.
22. Smialowicz, R. J., Riddle, M. M., Rogers, R. R., Luebke, R. W., Copeland C. B., and Ernst, G. G. 1990. Immune alterations in rats following subacute exposure to tributyltin oxide. Toxicology 64:169-178.
23. Smialowicz, R. J., Simmons, J.E., Luebke, R. W., and Allis, J. W. 1991. Immunotoxicologic assessment of subacute exposure of rats to carbon tetrachloride with comparison to hepatotoxicity and nephrotoxicity. Fundam. Appl. Toxicol. 17:186-196.
24. Snoeij, N. J., Penninks, A. H., and Seinen W. 1988. Dibutyltin and tributyltin compounds incude thymus atrophy in rats due to a selective action on thymic lymphoblasts. Int. J. Immunopharmacol. 10:891-899.
25. Snoeij, N. J., Penninks, A. H., and Seinen W. 1989. Thymus atrophy and immunosuppression induced by organotin compounds. Arch. Toxicol. (Suppl.) 13:171-174.
26. Snoeij, N. J., Van Iersel, A. A. J., Penninks, A. H., and Seinen, W. 1985. Toxicity of triorganotin compounds: Comparative in vivo studies with a series of trialkyltin compounds and triphenyltin chloride in male rats. Toxicol. Appl. Pharmacol. 81:274-286.
27. Sykes, M., Auchincloss, H., Jr., and Sachs, D. H. 2003. Transplantation Immunology. In Fundamental Immunology. 5th Edition, (Paul, W. E., Ed.), Lippincott Williams and Wilkins: Philadelphia, PA.
28. Temple, L., Butterworth, T. T., Kawabata, A. E., Munson, A. E., and White, K. L., Jr. 1995. ELISA to measure SRBC specific serum IgM: Method and data evaluation. In Methods in Immunology. Volume I (Burleson, G. R., Dean, J. H., and Munson, A. E., Eds.), Wiley-Liss, Inc.: New York.
29. Ueno, S., Kashimoto, T., Susa, N., Ishii, M., Chiba, T., Mutoh, K., Hoshi, F., Suzuki, T., and Sugiyama, M. 2003. Comparison of hepatotoxicity and metabolism of butyltin compounds in the liver of mice, rats, and guinea pigs. Arch. Toxicol. 77:173-181.
30. US EPA. 1997. Toxicological Review (CAS No. 56-35-9) in Support of Summary Information on the Integrated Risk Information System (IRIS).
31. US EPA. 2005. Fact Sheet: The Drinking Water Candidate Contaminant List-The Source of Priority Contaminants for the Dunking Water Program. EPA 815-F-05-001.
32. Verdier, F., Virat, M., Schweinfurth, H., and Descotes, J. 1991. Immunotoxicity of bis(tri-n-butyltin)oxide in the rat. J. Toxicol. Environ. Health. 32:307-317.
33. Vos, J. G., De Klert, A., Krajnc, E. I., Kruizinga, W., Van Ommen, B., and Rozing, J. 1984. Toxicity of bis(tri-n-butyltin)oxide in the rat. II. Suppression of thymus-dependent immune responses and of parameters of nonspecific resistance after short-term exposure. Toxicol. Appl. Pharmacol. 75:387-408.
34. Vos, J. G., DeKlerk, A., Krajnc, E. I., Van Loveren, H., and Rozing, J. 1990. Immunotoxicity of bis(tri-n-butyltin)oxide in the rat: Effect on thymus-dependent immunity and on nonspecific resistance following long-term exposure in young versus aged rats. Toxicol. Appl. Pharmacol. 105:144-155.
35. Whalen, M. M., Loganathan, B. G., and Kannan, K. 1999. Immunotoxicity of environmentally relevant concentrations of butyltins on human natural killer cells in vitro. Environ. Res. 81:108-116.
36. World Health Organization. 1980. Tin and Organotin Compounds: A Preliminary Review. Environmental Health Criteria 15. International Programme on Chemical Safety, Geneva, Switzerland.