Development and scale up of preparative HIC for the purification of a recombinant therapeutic protein

Chemical Engineering and Technology

Volumn 28, Issue 11, 2005, Pages 1398-1407

  Graumann, Klaus ^a   Ebenbichler, Adelheid Anna ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; COLUMN CHROMATOGRAPHY; HYDROPHOBIC CHROMATOGRAPHY; HYDROPHOBICITY; OPTIMIZATION; PURIFICATION; SEPARATION;

HOST CELL PROTEIN (HCP); HYDROPHOBIC INTERACTION CHROMATOGRAPHY (HIC); RECOMBINANT PROTEIN;

PROTEINS;

BIOTECHNOLOGY;

EID: 28144463212     PISSN: 09307516     EISSN: None     Source Type: Journal    
DOI: 10.1002/ceat.200500165     Document Type: Article

References (11)

1. A. Jungbauer, J. Chromatogr. A 2005, 1065 (1), 3.
2. G. Sofer, L. Hagel, Handbook of Process Chromatography - A Guide to Optimization, Scale-up and Validation, Academic Press, San Diego 1997.
3. F. Xia, D. Nagrath, S. Garde, S. M. Cramer, Biotechnol. Bioeng. 2004, 87 (3), 354.
4. S. Oscarsson, J. Chromatogr. B 1997, 699, 117.
5. F.-Y. Lin, W.-Y. Chen, M. T. W. Hearn, J. Mol. Recognit. 2002, 15, 55.
6. T. Tibbs Jones, E. J. Fernandez, Biotechnol. Bioeng. 2004, 87 (3), 388.
7. R. Hahn, K. Deinhofer, C. Machhold, A. Jungbauer, J Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2003, 790 (1-2), 99.
8. C. Machold, K. Deinhofer, R. Hahn, A. Jungbauer, J. Chromatogr. A 2002, 972 (1), 3.
9. K. Graumann, K. Guenther, E. Wert Castro, A. Ebenbichler, PREP2004 Symposium, Baltimore, MD, May 2004.
10. A. Rathore, A. Velayudhan, BioPharm Int. 2003 (1), 34.
11. Preparative and Production Scale Chromatography (Ed: G. Ganetsos), Marcel Dekker, New York 1993.