Study of hypocholesterolemic and antiatherosclerotic properties of Medicago sativa L. cultivated in Egypt

Journal of Food and Drug Analysis

Volumn 13, Issue 3, 2005, Pages 212-218

  Khaleel, Amal E ^a   Gad, Mohamed Z ^b   El Maraghy, Shohda A ^a   Hifnawy, Mohamed S ^a   Abdel Sattar, Essam ^c  

^a CAIRO UNIVERSITY   (Egypt)

^b Ain Shams University   (Egypt)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Alfalfa; Atherosclerosis; Canavanine; Cholesterol; Coumestrol; Hypercholesterolemia; LDL; Saponins

Indexed keywords

CANAVANINE; COUMESTROL; GEMFIBROZIL; HERBACEOUS AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEDICAGO SATIVA EXTRACT; SAPONIN; UNCLASSIFIED DRUG;

ALFALFA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; DRUG MONITORING; DRUG RESPONSE; DRUG SAFETY; EGYPT; HYPERCHOLESTEROLEMIA; NONHUMAN; PLANT GROWTH; RABBIT;

ANIMALIA; MEDICAGO SATIVA; ORYCTOLAGUS CUNICULUS;

EID: 28044464491     PISSN: 10219498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Benson, L. 1965. Plant Classification. pp. 244-247. Health and Co. Boston, U. S. A.
2. Mitchell, H. W. 1983. The British Herbal Pharmacopoeia. pp. 140. The British herbal medicine association.
3. Duke, J. A. 1985. CRC Handbook of Medicinal Herbs. pp. 299-300. Fl, CRC Press. Boca Raton, Florida, U. S. A.
4. Bialy, Z., Jurzysta, M., Oleszek, W., Piacente, S. and Pizza, C. 1999. Saponins in alfalfa (Medicago sativa L.) root and their structural elucidation. J. Agric. Food Chem. 47: 3185-3192.
5. Der Mardersian, A. and Liberti, L. 1988. Natural Product Medicine. pp. 247-249. G. F. Stickley. Philadelphia, U. S. A.
6. Nowacka, J. and Oleszek, W. 1994. Determination of alfalfa (Medicago sativa) saponins by high performance liquid chromatography. J. Agric. Food Chem. 42: 727-730.
7. Story, J. A., Le Page, S. L., Petro, M. S., West, L. G., Cassidy, M. M., Lightfoot, F. G. and Vahouny, G. H. 1984. Interactions of alfalfa plant and sprout saponins with cholesterol in vitro and in cholesterol-fed rats. Am. J. Clin. Nutr. 39: 917-929.
8. Malinow, M. R., McLaughlin, P., Papworth, L., Stafford, C., Kohler, G. O., Livingstone, A. L. and Cheeke, P. R. 1977. Effect of alfalfa saponins on intestinal cholesterol absorption in rats. Am. J. Clin. Nutr. 30: 2061-2067.
9. Dixit, V. P. and Joshi, S. C. 1985. Antiatherosclerotic effects of alfalfa meal ingestion in chicks: a biochemical evaluation. Ind. J. Physiol. Pharmac. 29: 47-50.
10. Yanaura, S. and Sakamoto, M. 1975. Influence of alfalfa meal on experimental hyperlipidaemia. Fol. Pharmacol. Jap. 71: 389-393.
11. Malinow, M. R., McLaughlin, P., Naito, H. K., Lewis, L. A. and McNulty, W. P. 1978. Effect of alfalfa meal on shrinkage (regression) of atherosclerotic plaques during cholesterol feeding in monkeys. Atherosclerosis 30: 27-43.
12. Colodny, L. R., Montgomery, A. and Houston, M. 2001. The role of esterin processed alfalfa saponins in reducing cholesterol. JANA 3: 6-15.
13. Malinow, M. R., McLaughlin, P., Bardana, E. J. and Craig, S. 1984. Elimination of toxicity from diets containing alfalfa seeds. Food Chem. Toxicol. 22: 584-587.
14. El-Hossary, G. A. 1970. A Phamacognostical Study of Certain Saponaria and Valeriana Species Growing in Egypt. pp. 132, 157-165. A thesis presented for Ph.D. degree, faculty of pharmacy, Cairo university. Cairo, Egypt.
15. Honerlagen, H. and Tretter, H. R. 1979. Zur routine-masigen quantitativen Gesamsaponinbestimmung in radix Panax und extrakten. Dent. Apoth. Zeitung 119, 1483-1486.
16. Hiai, S., Oura, H. and Hamanaka, H. 1976. Color reaction of some sapogenins and saponins with vanillin and sulfuric acid. Planta Med. 29: 116-122.
17. Allain, C. C., Poon, L. S., Chen, C. S., Richmond, W. and Fu, P. C. 1974. Enzymatic determination of total serum cholesterol. Clin. Chem. 20: 470-475.
18. Fossati, P. and Pencipe, L. 1982. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin. Chem. 28: 2077-2088.
19. Burstein, M., Scholnick, H. R. and Morin, R. 1970. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J. Lipid Res. 11: 583-595.
20. Isamail, M. F., Gad, M. Z. and Hamdy, M. A. 1999. Study of the hypolipidemic properties of pectin, garlic and ginseng in hypercholesterolemic rabbits. Pharmacol. Res. 39: 157-166.
21. Carleton, M. 1967. Histological Techniques. 4th ed. p. 166. Oxford Press. New York, U. S. A.
22. Kaul, D. and Kukreja, R. S. 1987. Atherogenesis: preventive action of triluoperazine. Atherosclerosis 64: 211-214.
23. Wojcicki, J., Samochowiec, L., Jaworska, M. and Hinek, A. A. 1985. Search for a model of experimental atherosclerosis: comparative studies in rabbits, guinea pigs and rats. Pol. J. Pharmacol. Pharm. 37: 11-21.
24. Sugano, M., Nakashima, Y., Tasaki, H., Takasugi, M., Kuroiwa, A. and Koide, O. 1988. Effects of deltiazem on suppression and regression of experimental atherosclerosis. Br. J. Exp. Pathol. 69: 515-523.
25. Molgaard, J., von Schenck, H. and Olsson, A. G. 1987. Alfalfa seeds lower low density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia. Atherosclerosis 65: 173-179.