Clear cell Sarcoma-like tumor with Osteoclast-like giant cells in the small bowel: Further evidence for a new tumor entity

International Journal of Surgical Pathology

Volumn 13, Issue 4, 2005, Pages 313-318

  Friedrichs, Nicolaus ^a   Testi, Maria Adele ^b   Moiraghi, Luisa ^b   Modena, Piergiorgio ^b   Paggen, Ellen ^a   Plötner, Andreas ^c   Wiechmann, Volker ^c   Mantovani Löffler, Luisa ^c   Merkelbach Bruse, Sabine ^a   Buettner, Reinhard ^a   Wardelmann, Eva ^a  

^a UNIVERSITY OF BONN   (Germany)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c Klinikum St Georg   (Germany)

Author keywords

Clear cell sarcoma; FISH; Multinucleated giant cells; Translocation

Indexed keywords

ACTIN; CD34 ANTIGEN; DESMIN; KI 67 ANTIGEN; MELAN A; PROTEIN BCL 2; PROTEIN HMB 45; PROTEIN S 100; SMOOTH MUSCLE ACTIN; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; UNCLASSIFIED DRUG; VIMENTIN;

ADULT; ARTICLE; CASE REPORT; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 22; CLEAR CELL SARCOMA; DIFFERENTIAL DIAGNOSIS; FLUORESCENCE IN SITU HYBRIDIZATION; GASTROINTESTINAL STROMAL TUMOR; GIANT CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL INTESTINE CANCER; TUMOR DIAGNOSIS;

ADULT; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 22; DIAGNOSIS, DIFFERENTIAL; GIANT CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; JEJUNAL NEOPLASMS; MALE; NEOPLASM PROTEINS; OSTEOCLASTS; PHOSPHOPYRUVATE HYDRATASE; RECEPTOR, NERVE GROWTH FACTOR; S100 PROTEINS; SARCOMA, CLEAR CELL; TRANSLOCATION, GENETIC; VIMENTIN;

EID: 28044453100     PISSN: 10668969     EISSN: None     Source Type: Journal    
DOI: 10.1177/106689690501300402     Document Type: Article

References (14)

1. Miettinen M, Sobin LH, Sarlomo-Rikala M. Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT). Mod Pathol 13:459-465, 2000
2. Fletcher CDM, Unni KK, Mertens F. Clear cell sarcoma of soft tissue. In Pathology and genetics of tumours of soft tissue and bone. IARCPress, Lyon, pp. 211-212, 2002
3. Chung EB, Enzinger FM. Malignant melanoma of soft parts. A reassessment of clear cell sarcoma. Am J Surg Pathol 7:405-413, 1983
4. Henkle CT, Hawkins AL, McCarthy EF, Griffin CA. Clear cell sarcoma case report: Complex karyotype including t(12;22) in primary and metastatic tumor. Cancer Genet Cytogenet 149:63-67, 2004
5. Kim YC, Vandersteen DP, Jung HG. Myxoid clear cell sarcoma. Am J Dermatopathol 27:51-55, 2005
6. Panagopoulos I, Mertens F, Debiec-Rychter M, Isaksson M, Limon J, Kardas I, Domanski HA, Sciot R, Perek D, Crnalic S, Larsson O, Mandahl N. Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses. Int J Cancer 99:560-567, 2002
7. Evans HL, Shipley J. Leiomyosarcoma. In Fletcher CD, Unni KK, Mertens F (eds). Tumours of soft tissue and bone. IARCPress, Lyon, pp. 131-134, 2002
8. Schaefer KL, Brachwitz K, Wai DH, Braun Y, Diallo R, Korsching E, Eisenacher M, Voss R, Van Valen F, Baer C, Selle B, Spahn L, Liao SK, Lee KA, Hogendoorn PC, Reifenberger G, Gabbert HE, Poremba C. Expression profiling of t(12;22)-positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3. Cancer Res 64:3395-405, 2004
9. Zambrano E, Reyes-Mugica M, Franchi A, Rosai J. An osteoclast-rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma of soft parts: Reports of 6 cases of a GIST simulator. Int J Surg Pathol 11:75-81, 2003
10. Covinsky M, Gong S, Rajaram V, Perry A, Pfeifer J. EWS-ATF1 fusion transcripts in gastrointestinal tumors previously diagnosed as malignant melanoma. Hum Pathol 36:74-81, 2005
11. Alpers CE, Beckstead JH. Malignant neuroendocrine tumor of the jejunum with osteoclast-like giant cells. Enzyme histochemistry distinguishes tumor cells from giant cells. Am J Surg Pathol 9:57-64, 1985
12. Donner LR, Trompler RA, Dobin S. Clear cell sarcoma of the ileum: The crucial role of cytogenetics for the diagnosis. Am J Surg Pathol 22:121-124, 1998
13. Fukuda T, Kakihara T, Baba K, Yamaki T, Yamaguchi T, Suzuki T. Clear cell sarcoma arising in the transverse colon. Pathol Int 50:412-416, 2000
14. Pauwels P, Debiec-Rychter M, Sciot R, Vlasveld T, den Butter B, Hagemeijer A, Hogendoorn PC. Clear cell sarcoma of the stomach. Histopathology 41:526-530, 2002