Telomerase catalytic subunit gene expression does not influence survival of patients with squamous cell carcinoma of the larynx and hypopharynx: A case-control study

Journal of Laryngology and Otology

Volumn 119, Issue 11, 2005, Pages 917-921

  Luzar, Boštjan ^a   Poljak, Mario ^a   Fischinger, Janez ^b   Klopčič, Ulrika ^c   Gale, Nina ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^c INSTITUTE OF ONCOLOGY   (Slovenia)

Author keywords

Carcinoma; Hypopharynx; Larynx; Squamous Cell; Survival; Telomerase

Indexed keywords

MESSENGER RNA; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CANCER GRADING; CANCER LOCALIZATION; CANCER SIZE; CANCER SURVIVAL; CASE CONTROL STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; ENZYME SUBUNIT; FEMALE; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHARYNX CARCINOMA; LARYNX CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PREDICTION; PROGNOSIS; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; DNA-BINDING PROTEINS; EPIDEMIOLOGIC METHODS; FEMALE; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPOPHARYNGEAL NEOPLASMS; LARYNGEAL NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; TELOMERASE; TUMOR MARKERS, BIOLOGICAL;

EID: 28044441320     PISSN: 00222151     EISSN: None     Source Type: Journal    
DOI: 10.1258/002221505774783403     Document Type: Article

References (23)

1. Quon H, Liu FF, Cummings BJ. Potential molecular prognostic markers in head and neck squamous cell carcinomas. Head Neck 2001;23:147-59
2. Helliwell TR. Evidence based pathology: squamous carcinoma of the hypopharynx. J Clin Pathol 2003;56:81-5
3. Blackburn EH. Structure and function of telomeres. Nature 1991;350:569-73
4. Ulaner G. Telomere maintenance in clinical medicine. Am J Med 2004;117:262-9
5. Shanmugaratnam K. Histological typing of tumours of the upper respiratory tract and ear. Berlin: Springer Verlag, 1997
6. Sobin LH, Whittekind C, eds. TNM classification of malignant tumors, 5th edn. New York: Wiley-Liss, 1997;27-42
7. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 1993;54:594-606
8. Pompe-Kirn V, Golouh R, Lindtner J, Primic-Žakelj M, Ravnihar B, Rudolf Z et al. eds. Incidenca raka v Sloveniji [Cancer incidence in Slovenia]. Ljubljana: Onkološki Inštitut, 2002;1-75
9. Blot WJ. Invited commentary: more evidence of increased risks of cancer among alcohol drinkers. Am J Epidemiol 1999;150:1138-40
10. Visser O, Coeberth JWW, Schouten LJ, van Dijck JAAM. Incidence of Cancer in the Netherlands 1994. Sixth Report of the Netherlands Cancer Registry. Utrecht: Vereniging van Integrale Kankercentra, 1997
11. Koscielny S, Eggeling F, Dahse R, Fiedler W. The influence of reactivation of the telomerase in tumour tissue on the prognosis of squamous cell carcinomas in the head and neck. J Oral Pathol Med 2004;33:538-42
12. Liao CT, Tung-Chieh Chang J, Wang HM, Chen IH, Lin CY, Chen TM et al. Telomerase as an independent prognostic factor in head and neck squamous cell carcinoma. Head Neck 2004;26:504-12
13. Patel MM, Parekh LJ, Jha FP, Sainger RN, Patel JB, Patel DD et al. Clinical usefulness of telomerase activation and telomere length in head and neck cancer. Head Neck 2002;24:1060-7
14. Thurnher D, Knerer B, Formanek M, Kornfehl J. Non-radioactive semiquantitative testing for expression levels of telomerase activity in head and neck squamous cell carcinomas may be indicative for biological tumour behaviour. Acta Otolaryngol (Stockh) 1998;118:423-7
15. Hohaus S, Cavallo S, Bellacosa A, Genuardi M, Galli J, Cadoni G et al. Telomerase activity in human laryngeal squamous cell carcinomas. Clin Cancer Res 1996;2:1890-5
16. Curran AJ, Gullane PJ, Irish J, Macmillan C, Freeman J, Kamel-Reid S. Telomerase activity is upregulated in laryngeal squamous cell carcinoma. Laryngoscope 2000;110:391-6
17. Schneider-Stock R, Emrich T, Peters B, Jaeger V, Roessner A. Analysis of human telomerase reverse transcriptase mRNA (hTERT) expression in myxoid liposarcomas using LightCycler real-time quantitative reverse transcriptase-polymerase chain reaction. Electrophoresis 2001;22:1098-101
18. Schrader M, Burger AM, Muller M, Krause H, Straub B, Smith GL et al. Quantification of human telomerase reverse transcriptase mRNA in testicular germ cell tumors by quantitative fluorescence real-time RT-PCR. Oncol Rep 2002;9:1097-105
19. Luzar B, Poljak M, Marin IJ, Gale N. Telomerase reactivation is an early event in laryngeal carcinogenesis. Mod Pathol 2003;16:841-8
20. Fujimoto R, Kamata N, Yokoyama K, Ueda N, Satomura K, Hayashi E et al. Expression of telomerase components in oral keratinocytes and squamous cell carcinomas. Oral Oncol 2001;37:132-40
21. Luzar B, Poljak M, Marin IJ, Fischinger J, Gale N. Quantitative measurement of telomerase catalytic subunit (hTERT) mRNA in laryngeal squamous cell carcinomas. Anticancer Res 2001;21:4011-15
22. Nadal A, Cardesa A. Molecular biology of laryngeal squamous cell carcinoma. Virchows Arch 2003;442:1-7
23. Forastiere A, Koch W, Trotti A, Sidransky D. Head and neck cancer. N Engl J Med 2001;345:1890-900