Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors

Journal of Cellular Biochemistry

Volumn 96, Issue 5, 2005, Pages 1034-1048

  Weng, Jinsheng ^a   Ma, Wenbin ^a   Mitchell, Dianne ^a   Zhang, Jianshe ^b   Liu, Mingyao ^a,c  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

^b CHANGSHA UNIVERSITY   (China)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

IL 6; OR51E2; Prostate cancers; Prostate specific G protein coupled receptor; Prostate specific promoters; PSGR; Transcriptional regulation

Indexed keywords

CYTOKINE; G PROTEIN COUPLED RECEPTOR; GROWTH FACTOR; INTERLEUKIN 6; LUCIFERASE; NUCLEOTIDE; PROSTATE SPECIFIC G PROTEIN COUPLED RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CONTROLLED STUDY; DNA SEQUENCE; EXON; GC RICH SEQUENCE; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRON; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE TUMOR; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PSGR GENE; REGULATORY MECHANISM; TATA BOX; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; CELL LINE, TUMOR; DISEASE PROGRESSION; DNA PRIMERS; ENHANCER ELEMENTS (GENETICS); EXONS; GENOME; HELA CELLS; HUMANS; INTERLEUKIN-6; INTRONS; LUCIFERASES; MALE; MICE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); PROSTATIC NEOPLASMS; RECEPTORS, ODORANT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; SOFTWARE; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 28044438196     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20600     Document Type: Article

References (49)

1. Accili D, Arden KC. 2004. Foxos at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117:421-426.
2. Alien LF, Lefkowitz RJ, Caron MG, Cotecchia S. 1991. G-protein-coupled receptor genes as protooncogenes: Constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc Natl Acad Sci USA 88:11354-11358.
3. Andersen B, Rosenfeld MG. 1994. Pit-1 determines cell types during development of the anterior pituitary gland. A model for transcriptional regulation of cell phenotypes in mammalian organogenesis. J Biol Chem 269:29335-29338.
4. Arvanitakis L, Geras-Raaka E, Varma A, Gershengorn MC, Cesarman E. 1997. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature 385:347-350.
5. Boyce FM, Beggs AH, Feener C, Kunkel LM. 1991. Dystrophin is transcribed in brain from a distant upstream promoter. Proc Natl Acad Sci USA 88:1276-1280.
6. Brunei A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. 2004. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015.
7. Chelly J, Hamard G, Koulakoff A, Kaplan JC, Kahn A, Berwald-Netter Y. 1990. Dystrophin gene transcribed from different promoters in neuronal and glial cells. Nature 344:64-65.
8. Chen T, Wang LH, Farrar WL. 2000. Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells. Cancer Res 60:2132-2135.
9. Chung TD, Yu JJ, Spiotto MT, Bartkowski M, Simons JW. 1999. Characterization of the role of IL-6 in the progression of prostate cancer. Prostate 38:199-207.
10. Courtois SJ, Lafontaine DA, Rousseau GG. 1992. Characterization of an alternative promoter in the human growth hormone gene. J Biol Chem 267:19736-19743.
11. Culig Z, Bartsch G, Hobisch A. 2002. Interleukin-6 regulates androgen receptor activity and prostate cancer cell growth. Mol Cell Endocrinol 197:231-238.
12. Deeble PD, Murphy DJ, Parsons SJ, Cox ME. 2001. Interleukin-6- and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells. Mol Cell Biol 21:8471-8482.
13. Drachenberg DE, Elgamal AA, Rowbotham R, Peterson M, Murphy GP. 1999. Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer. Prostate 41:127-133.
14. Edwards SW, Tan CM, Limbird LE. 2000. Localization of G-protein-coupled receptors in health and disease. Trends Pharmacol Sci 21:304-308.
15. Giri D, Ozen M, Ittmann M. 2001. Interleukin-6 is an autocrine growth factor in human prostate cancer. Am J Pathol 159:2159-2165.
16. Gonzalez-Crespo S, Boronat A. 1991. Expression of the rat growth hormone-releasing hormone gene in placenta is directed by an alternative promoter. Proc Natl Acad Sci USA 88:8749-8753.
17. Gutkind JS. 1998a. Cell growth control by G-protein-coupled receptors: From signal transduction to signal integration. Oncogene 17:1331-1342.
18. Gutkind JS. 1998b. The pathways connecting G-protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 273:1839-1842.
19. Hobisch A, Eder IE, Putz T, Horninger W, Bartsch G, Klocker H, Culig Z. 1998. Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor. Cancer Res 58:4640-4645.
20. Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Kanada N, Saso H, Kobayashi R, Hung MC. 2004. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117:225-237.
21. Keller ET, Chang C, Ershler WB. 1996. Inhibition of NFkappaB activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone- mediated repression of the interleukin-6 promoter. J Biol Chem 271:26267-26275.
22. Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH III, Wright CV, White MF, Arden KC, Accili D. 2002. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110:1839-1847.
23. Lee SH, Minowa MT, Mouradian MM. 1996. Two distinct promoters drive transcription of the human D1A dopamine receptor gene. J Biol Chem 271:25292-25299.
24. Lin YH, Shin EJ, Campbell MJ, Niederhuber JE . 1995. Transcription of the blk gene in human B lymphocytes is controlled by two promoters. J Biol Chem 270:25968-25975.
25. Lin J, Adam RM, Santiestevan E, Freeman MR. 1999. The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res 59:2891-2897.
26. Nakae J, Kitamura T, Kitamura Y, Biggs WH III, Arden KC, Accili D. 2003. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev Cell 4:119-129.
27. Neubig RR. 2002. Regulators of G protein signaling (RGS proteins): Novel central nervous system drug targets. J Pept Res 60:312-316.
28. Overdier DG, Ye H, Peterson RS, Clevidence DE, Costa RH. 1997. The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney. J Biol Chem 272:13725-13730.
29. Perez-Stable CM, Pozas A, Roos BA. 2000. A role for GATA transcription factors in the androgen regulation of the prostate-specific antigen gene enhancer. Mol Cell Endocrinol 167:43-53.
30. Qiu Y, Ravi L, Kung HJ. 1998. Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells. Nature 393:83-85.
31. Ren H, Stiles GL. 1995. Separate promoters in the human A1 adenosine receptor gene direct the synthesis of distinct messenger RNAs that regulate receptor abundance. Mol Pharmacol 48:975-980.
32. Shields JM, Yang VW. 1998. Identification of the DNA sequence that interacts with the gut-enriched Kruppel-like factor. Nucleic Acids Res 26:796-802.
33. Smith PC, Hobisch A, Lin DL, Culig Z, Keller ET. 2001. Interleukin-6 and prostate cancer progression. Cytokine Growth Factor Rev 12:33-40.
34. Stafford LJ, Xia C, Ma W, Cai Y, Liu M. 2002. Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res 62:5399-5404.
35. Steiner H, Godoy-Tundidor S, Rogatsch H, Berger AP, Fuchs D, Comuzzi B, Bartsch G, Hobisch A, Culig Z. 2003. Accelerated in vivo growth of prostate tumors that up-regulate interleukin-6 is associated with reduced retinoblastoma protein expression and activation of the mitogen-activated protein kinase pathway. Am J Pathol 162:655-663.
36. Timmusk T, Palm K, Metsis M, Reintam T, Paalme V, Saarma M, Persson H. 1993. Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10:475-489.
37. Tran H, Brunet A, Griffith EC, Greenberg ME. 2003. The many forks in FOXO's road. Sci STKE 172:Re5.
38. Ueda T, Bruchovsky N, Sadar MD. 2002. Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. J Biol Chem 277:7076-7085.
39. Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF. 2003. Novel human G-protein-coupled receptors. Biochem Biophys Res Commun 305:67-71.
40. Wadman IA, Osada H, Grutz GG, Agulnick AD, Westphal H, Forster A, Rabbitts TH. 1997. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J 16:3145-3157.
41. Weng J, Wang J, Cai Y, Stafford LJ, Mitchell D, Ittmann M, Liu M. 2005. Increased expression of prostate-specific G-protein coupled receptor (PSGR) in human prostate intraepithelial neoplasia (PIN) and prostate cancers. Int J Cancer 113(5):811-818.
42. Xia C, Ma W, Stafford LJ, Marcus S, Xiong WC, Liu M. 2001a. Regulation of the p21-activated kinase (PAK) by a human Gbeta-like WD-repeat protein, hPIP1. Proc Natl Acad Sci USA 98:6174-6179.
43. Xia C, Ma W, Wang F, Hua S, Liu M. 2001b. Identification of a prostate-specific G-protein coupled receptor in prostate cancer. Oncogene 20:5903-5907.
44. Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M. 2003. GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins. Mol Cell Biol 23:2476-2488.
45. Xu Y, Fang XJ, Casey G, Mills GB. 1995. Lysophospholipids activate ovarian and breast cancer cells. Biochem J 309(Pt 3):933-940.
46. Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG, Moul JW, Soppett D, Srivastava S. 2000. PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. Cancer Res 60:6568-6572.
47. Yang L, Wang L, Lin HK, Kan PY, Xie S, Tsai MY, Wang PH, Chen YT, Chang C. 2003. Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells. Biochem Biophys Res Commun 305:462-469.
48. Young D, Waitches G, Birchmeier C, Fasano O, Wigler M. 1986. Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell 45:711-719.
49. Yuan TT, Toy P, McClary JA, Lin RJ, Miyamoto NG, Kretschmer PJ. 2001. Cloning and genetic characterization of an evolutionary conserved human olfactory receptor that is differentially expressed across species. Gene 278:41-51.