Evaluation of CD8+ T-cell and antibody responses following transient increased viraemia in rhesus macaques infected with live, attenuated simian immunodeficiency virus

Journal of General Virology

Volumn 86, Issue 12, 2005, Pages 3375-3384

  Metzner, Karin J ^a,g   Moretto, Walter J ^b   Donahoe, Sean M ^a,h   Jin, Xia ^c   Gettie, Agegnehu ^a   Montefiori, David C ^d   Marx, Preston A ^e   Binley, James M ^f   Nixon, Douglas F ^b   Connor, Ruth I ^a,i  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^f TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^g UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^h HARVARD MEDICAL SCHOOL   (United States)

ⁱ DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN GP 130; NEUTRALIZING ANTIBODY; PROTEIN ANTIBODY; PROTEIN P27; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BLOOD CELL; CELLULAR IMMUNITY; CHEMOPROPHYLAXIS; CONTROLLED STUDY; IN VIVO STUDY; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; MACACA; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; SUPPRESSOR CELL; VACCINATION; VIREMIA; VIRUS INFECTION; VIRUS LOAD; VIRUS REPLICATION;

ANIMALS; ANTIBODIES, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE PRODUCTS, ENV; GENE PRODUCTS, GAG; LYMPHOCYTE DEPLETION; MACACA MULATTA; NEUTRALIZATION TESTS; RNA, VIRAL; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIREMIA;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA; MACACA MULATTA; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 28044435084     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.81206-0     Document Type: Article

References (35)

1. Almond, N., Rose, J., Sangster, R., Silvera, P., Stebbings, R., Walker, B. & Stott, E. J. (1997). Mechanisms of protection induced by attenuated simian immunodeficiency virus. I. Protection cannot be transferred with immune serum. J Gen Virol 78, 1919-1922.
2. Baba, T. W., Jeong, Y. S., Pennick, D., Bronson, R., Greene, M. F. & Ruprecht, R. M. (1995). Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267, 1820-1825.
3. Baba, T. W., Liska, V., Khimani, A. H. & 8 other authors (1999). Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques. Nat Med 5, 194-203.
4. Barouch, D. H., Santra, S., Schmitz, J. E. & 26 other authors (2000). Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 290, 486-492.
5. Chakrabarti, L. A., Lewin, S. R., Zhang, L. & 7 other authors (2000). Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection. J Virol 74, 1209-1223.
6. Connor, R. I., Montefiori, D. C., Binley, J. M. & 8 other authors (1998). Temporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine. J Virol 72, 7501-7509.
7. Douek, D. C., McFarland, R. D., Keiser, P. H. & 11 other authors (1998). Changes in thymic function with age and during the treatment of HIV infection. Nature 396, 690-695.
8. Egan, M. A., Charini, W. A., Kuroda, M. J. & 10 other authors (2000). Simian immunodeficiency virus (SIV) gag DNA-vaccinated rhesus monkeys develop secondary cytotoxic T-lymphocyte responses and control viral replication after pathogenic SIV infection. J Virol 74, 7485-7495.
9. + T cell responses in a cohort of chronically infected patients are associated with interruptions in anti-HIV chemotherapy. J Infect Dis 181, 1264-1272.
10. Hazenberg, M. D., Otto, S. A., Cohen Stuart, J. W. T. & 11 other authors (2000). Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nat Med 6, 1036-1042.
11. + T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med 189, 991-998.
12. Kostrikis, L. G., Tyagi, S., Mhlanga, M. M., Ho, D. D. & Kramer, R. F. (1998). Spectral genotyping of human alleles. Science 279, 1228-1229.
13. Larsson, M., Jin, X. Ramratnam, B. & 8 other authors (1999). A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals. AIDS 13, 767-777.
14. + lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment. J Virol 75, 10187-10199.
15. Mackall, C. L., Hakim, F. T. & Gress, R. E. (1997). Restoration of T-cell homeostasis after T-cell depletion. Semin Immunol 9, 339-346.
16. Mackay, G. A., Liu, Z., Singh, D. K. & 9 other authors (2004). Protection against late-onset AIDS in macaques prophylactically immunized with a live simian HIV vaccine was dependent on persistence of the vaccine virus. J Immunol 173, 4100-4107.
17. Madden, L. J., Zandonatti, M. A., Flynn, C. T., Taffe, M. A., Marcondes, M. C., Schmitz, J. E., Reimann, K. A., Henriksen, S. J. & Fox, H. S. (2004). CD8+ cell depletion amplifies the acute retroviral syndrome. J Neurovirol 10 (Suppl. 1), 58-66.
18. + T cell depletion on virus replication in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine. J Exp Med 191, 1921-1931.
19. Montefiori, D. C., Robinson, W. E., Jr, Schuffman, S. S. & Mitchell, W. M. (1988). Evaluation of antiviral drugs and neutralizing antibodies to human immunodeficiency virus by a rapid and sensitive microtiter infection assay. J Clin Microbiol 26, 231-235.
20. Montefiori, D. C., Baba, T. W., Li, A., Bilska, M. & Ruprecht, R. M. (1996). Neutralizing and infection-enhancing antibody responses do not correlate with the differential pathogenicity of SIVmac239delta3 in adult and infant rhesus monkeys. J Immunol 157, 5528-5535.
21. Moretto, W. J., Drohan, L. A. & Nixon, D. F. (2000). Rapid quantification of SIV-specific CD8 T cell responses with recombinant vaccinia virus ELISPOT or cytokine flow cytometry. AIDS 14, 2625-2627.
22. Pantaleo, G. & Koup, R. A. (2004). Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know. Nat Med 10, 806-810.
23. Rasmussen, R. A., Hofmann-Lehmann, R., Li, P.-L. & 8 other authors (2002). Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques. AIDS 16, 829-838.
24. Regier, D. A. & Desrosiers, R. C. (1990). The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus. AIDS Res Hum Retroviruses 6, 1221-1231.
25. + lymphocytes. Science 283, 857-860.
26. Schmitz, J. E., Kuroda, M. J., Santra, S. & 14 other authors (2003). Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus. J Virol 77, 2165-2173.
27. Sharpe, S. A., Cope, A., Dowall, S. & 8 other authors (2004). Macaques infected long-term with attenuated simian immunodeficiency virus (SIVmac) remain resistant to wild-type challenge, despite declining cytotoxic T lymphocyte responses to an immunodominant epitope. J Gen Virol 85, 2591-2602.
28. Sodora, D. L., Douek, D. C., Silvestri, G. & 8 other authors (2000). Quantification of thymic function by measuring T cell receptor excision circles within peripheral blood and lymphoid tissues in monkeys. Eur J Immunol 30, 1145-1153.
29. Trkola, A., Kuster, H., Leemann, C. & 10 other authors (2004). Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set point. Blood 104, 1784-1792.
30. Van Rompay, K. K. A., Cherrington, J. M., Marthas, M. L. & 8 other authors (1996). 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob Agents Chemother 40, 2586-2591.
31. Van Rompay, K. K. A., Cherrington, J. M., Marthas, M. L., Lamy, P. D., Dailey, P. J., Canfield, D. R., Tarara, R. P., Bischofberger, N. & Pedersen, N. C. (1999). 9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) therapy prolongs survival of infant macaques inoculated with simian immunodeficiency virus with reduced susceptibility to PMPA. Antimicrob Agents Chemother 43, 802-812.
32. Van Rompay, K. K. A., Miller, M. D., Marthas, M. L. & 8 other authors (2000). Prophylactic and therapeutic benefits of short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) administration to newborn macaques following oral inoculation with simian immunodeficiency virus with reduced susceptibility to PMPA. J Virol 74, 1767-1774.
33. + -cell-mediated suppression of virulent simian immunodeficiency virus during tenofovir treatment. J Virol 78, 5324-5337.
34. Whitney, J. B. & Ruprecht, R. M. (2004). Live attenuated HIV vaccines: pitfalls and prospects. Curr Opin Infect Dis 17, 17-26.
35. Zhang, L., Lewin, S. R., Markowitz, M. & 16 other authors (1999). Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy. J Exp Med 190, 725-732.