Pyroglutamic acidosis in a renal transplant patient

Nephrology Dialysis Transplantation

Volumn 20, Issue 12, 2005, Pages 2836-2838

  Foot, Carole L ^a   Fraser, John F ^a   Mullany, Daniel V ^a  

^a THE PRINCE CHARLES HOSPITAL   (Australia)

Author keywords

Acid base disorders; Acidosis; Glutathione; Renal transplant

Indexed keywords

ACETYLSALICYLIC ACID; AMLODIPINE; ANTIBIOTIC AGENT; BICARBONATE; CALCITRIOL; CODEINE; CORTICOSTEROID; HYPERTENSIVE FACTOR; INOTROPIC AGENT; MULTIVITAMIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PARACETAMOL; PREDNISOLONE; PYROGLUTAMIC ACID; TACROLIMUS;

ABDOMINAL PAIN; ADULT; ANION GAP; ANOREXIA; ARTICLE; BACTERIAL ARTHRITIS; BLOOD GAS ANALYSIS; CASE REPORT; CONFUSION; DROWSINESS; DYSPNEA; ECCHYMOSIS; FEMALE; HEMODIALYSIS; HUMAN; HYDRATION; HYPOTENSION; HYPOTHERMIA; KIDNEY GRAFT; LETHARGY; MEDULLARY SPONGE KIDNEY; METABOLIC ACIDOSIS; MITRAL VALVE REGURGITATION; NEUROLOGIC DISEASE; PRIORITY JOURNAL; SEPTIC SHOCK; TACHYCARDIA; URETER SURGERY;

ACIDOSIS; DIAGNOSIS, DIFFERENTIAL; DISEASE PROGRESSION; FATAL OUTCOME; FEMALE; HUMANS; KIDNEY FAILURE, ACUTE; KIDNEY TRANSPLANTATION; MEDULLARY SPONGE KIDNEY; MIDDLE AGED; PYRROLIDONECARBOXYLIC ACID;

EID: 27944508779     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfi184     Document Type: Article

References (10)

1. Pitt J, Hauser S. Transient 5-oxoprolinuria and high anion gap metabolic acidosis: Clinical and biochemical findings in eleven subjects. Clin Chem 1998; 44: 336-340
2. Al-Jishi E, Meyer B, Rashed M et al. Clinical, biochemical, and molecular characterization of patients with glutathione synthetase deficiency. Clin Genet 1999; 55: 444-449
3. Persaud C, Forrester T, Jackson A. Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased during recovery from severe childhood malnutrition and responds to supplemental glycine. J Nutr 1996; 126: 2823-2830
4. Persaud C, McDermott J, De Benoist B et al. The excretion of 5-oxoproline (pyroglutamic acid) as on index of glycine status during normal pregnancy. Br J Obstet Gynaecol 1989; 96: 440-444
5. Yong-Ming Y, Ryan C, Zhe-Wei F et al. Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humans. Am J Physiol Endocrinol Metab 2002; 282: 247-258
6. Creer H, Lau B, Jones J, Chan K. Pyroglutamic acidemia in an adult patient. Clin Chem 1989; 35: 684-686
7. Croal B, Glen A, Kelly C, Logan R. Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy. Clin Chem 1998; 44: 336-340
8. Dempsey G, Lyall H, Corke C, Scheinkestel C. Pyroglutamic acidemia: A cause of high anion gap metabolic acidosis. Crit Care Med 2000; 28: 1803-1807
9. Mizock B, Belyaev S, Mecher C. Unexplained metabolic acidosis in critically ill patients: The role of pyroglutamic acid. Intensive Care Med 2004; 30: 502-505
10. Balasubramanyan N, Havens P, Hoffman G. Unmeasured anions identified by the fencl-Stewart method predict mortality better than base excess, anion gap, and lactate in patients in the pediatric intensive care unit. Crit Care Med 1999; 27: 1577-1581