Can the therapeutic window for tissue plasminogen activator be extended to 6 hours after stroke onset?

Nature Clinical Practice Cardiovascular Medicine

Volumn 2, Issue 7, 2005, Pages 342-343

  Alexandrov, Andrei V ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b NONE   (United States)

Author keywords

MRI; Stroke; Tissue plasminogen activator; Transcranial Doppler imaging

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

BLEEDING; BLOOD CLOT; BOLUS INJECTION; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; DIFFUSION WEIGHTED IMAGING; DISEASE SEVERITY; DOPPLER ECHOGRAPHY; DRUG CONTRAINDICATION; DRUG EFFICACY; DRUG SAFETY; HUMAN; INTERNAL CAROTID ARTERY OCCLUSION; MAGNETIC RESONANCE ANGIOGRAPHY; MIDDLE CEREBRAL ARTERY OCCLUSION; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT SELECTION; PERFUSION WEIGHTED IMAGING; PRIORITY JOURNAL; RECANALIZATION; SHORT SURVEY; STROKE;

CEREBROVASCULAR ACCIDENT; FIBRINOLYTIC AGENTS; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING; PROSPECTIVE STUDIES; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 27944491239     PISSN: 17434297     EISSN: 17434300     Source Type: Journal    
DOI: 10.1038/ncpcardio0243     Document Type: Short Survey

References (5)

1. Hacke W et al.; the ATLANTIS, ECASS, and NINDS-rt-PA Investigators (2004) Association of outcome with early stroke treatment: Pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 363: 768-774
2. Tanne D et al. (2002) Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: The Multicenter rt-PA Stroke Survey. Circulation 105: 1679-1685
3. Warach S (2001) Tissue viability thresholds in acute stroke: The 4-factor model. Stroke 32: 2460-2461
4. Davalos A et al. (2004) The clinical-DWI mismatch: A new diagnostic approach to the brain tissue at risk of infarction. Neurology 62: 2187-2192
5. Chemyshev OY et al. (2005) Yield and accuracy of urgent combined carotid/ transcranial ultrasound testing in acute cerebral ischemia. Stroke 36: 32-37