Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 2, 2006, Pages 457-460

  Gopalsamy, Ariamala ^a   Aplasca, Alexis ^a   Ciszewski, Gregory ^a   Park, Kaapjoo ^a   Ellingboe, John W ^a   Orlowski, Mark ^a   Feld, Boris ^a   Howe, Anita Y M ^a  

^a WYETH RESEARCH   (United States)

Author keywords

3,4 Dihydro 1H 1 benzothieno 2,3 c pyran; 3,4 Dihydro 1H pyrano 3,4 b benzofuran; HCV polymerase inhibitors

Indexed keywords

ALKYL GROUP; ANTIVIRUS AGENT; AROMATIC COMPOUND; BENZOFURAN DERIVATIVE; FUNCTIONAL GROUP; NUCLEOTIDYLTRANSFERASE INHIBITOR; PYRAN DERIVATIVE; RNA DIRECTED RNA POLYMERASE;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HEPATITIS C VIRUS; IC 50; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOFURANS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; PYRANS; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 27944467051     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.08.114     Document Type: Article

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16. HPLC Conditions: CHIRAL PACK-AD (250X20 mm) column, 10% isopropyl alcohol in heptane (0.1% TFA) eluant.
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