Histologic effects of laser-assisted topical anesthesia in a porcine model

Academic Emergency Medicine

Volumn 12, Issue 12, 2005, Pages 1148-1152

  Singer, Daniel D ^a   Singer, Adam J ^a,c   McClain, Steve A ^a   Tortora, George ^b  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Infection; Laser; Scarring; Stratum corneum

Indexed keywords

ALUMINUM; EOSIN; ERBIUM; HEMATOXYLIN; ISOFLURANE; YTTRIUM;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; BACTERIAL GROWTH; BASEMENT MEMBRANE; BIOPSY; COLONY FORMING UNIT; CONFIDENCE INTERVAL; CONTROLLED STUDY; DATA ANALYSIS; DEVICE; ELECTRON MICROSCOPY; EPIDERMIS; EPIDERMIS HYPERPLASIA; HISTOLOGY; HYPERKERATOSIS; INFECTION; INOCULATION; IRRADIATION; LASER; NECROSIS; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCAR FORMATION; STAINING; STAPHYLOCOCCUS AUREUS; STATISTICS; STRATUM CORNEUM; SWINE; TOPICAL ANESTHESIA; WOUND DRESSING;

ADMINISTRATION, TOPICAL; ANESTHESIA, LOCAL; ANIMALS; BACTERIAL INFECTIONS; DISEASE MODELS, ANIMAL; FEMALE; LASER THERAPY, LOW-LEVEL; RANDOM ALLOCATION; REFERENCE VALUES; SKIN; SUS SCROFA; WOUND HEALING;

EID: 27944466829     PISSN: 10696563     EISSN: None     Source Type: Journal    
DOI: 10.1197/j.aem.2005.07.015     Document Type: Article

References (21)

1. F.N. Marzulli Barriers to skin penetration J Invest Dermatol 39 1962 387 393
2. K.C. Madison Barrier function of the skin: "La raison d'etre" of the epidermis J Invest Dermatol 121 2003 231 241
3. J. Luhmann, S. Hurt, M. Shootman, and R. Kennedy A comparison of buffered lidocaine versus ELA-Max before peripheral intravenous catheter insertions in children Pediatrics 113 2004 217 220
4. H. Vaghadia, O.A. al-Ahdal, and K. Nevin EMLA patch for intravenous cannulation in adult surgical outpatients Can J Anaesth 44 1997 798 802
5. M.R. Prausnitz, V. Bose, R. Langer, and J.C. Weaver Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery Proc Natl Acad Sci U S A 90 1993 10504 10508
6. S. Mitragotri, and J. Kost Low-frequency sonophoresis: a review Adv Drug Deliv Rev 27 2004 589 601
7. P.G.M. Van Der Valk, and H.I. Maibach A functional study of the skin barrier to evaporative water loss by means of repeated cellophane-tape stripping Clin Exp Dermatol 15 1990 180 182
8. A.J. Singer, J. Shallat, S. Vallentine, L. Doyle, and H.C. Thode Cutaneous tape stripping to enhance topical drug absorption. A randomized controlled trial Acad Emerg Med 5 1998 1051 1056
9. P.L. Yun, R. Tachihara, and R.R. Anderson Efficacy of erbium:yttrium-aluminum-garnet laser-assisted delivery of topical anesthetic J Am Acad Dermatol 47 2002 542 547
10. H. Shapiro, L. Harris, F. Hetzel, and D. Bar-Or Laser assisted delivery of topical anesthesia for intramuscular needle insertion in adults Lasers Surg Med 31 2002 252 256
11. E.D. Baron, L. Harris, and W.S. Redpath Laser-assisted penetration of topical anesthetic in adults Arch Dermatol 139 2003 1288 1290
12. Singer AJ, Regev R, Weeks R, Tolckwoski D. Laser-assisted anesthesia prior to intravenous cannulation in volunteers: a randomized controlled trial. Acad Emerg Med. 2005;12:804-7.
13. R. Weeks, A.J. Singer, and R. Regev Use of a laser device to enhance anesthesia prior to venous cannulation in emergency department patients Acad Emerg Med 12 Suppl 2005 S155 S156
14. T.P. Sullivan, W.H. Eaglstein, S.C. Davis, and P. Mertz The pig as a model for human wound healing Wound Rep Reg 9 2001 66 76
15. National Research Council Guide for the Care and Use of Laboratory Animals 1996 National Academy Press Washington, DC
16. A.J. Singer, S.A. McClain, and H.C. Thode Jr. Development of a histomorphologic scale to quantify cutaneous scars after burns Acad Emerg Med 7 2000 1083 1088
17. T. Alster, and J. Lupton Erbium: YAG cutaneous laser resurfacing Dermatol Clin 19 2001 453 466
18. K.A. Khatri Ablation of cutaneous lesions using an erbium: YAG laser J Cosmet Laser Ther 5 2003 150 153
19. E. Papadavid, and A. Katsambas Lasers for facial rejuvenation: a review Int J Dermatol 42 2003 480 487
20. D.J. Dire, M. Coppola, D.A. Dwyer, J.J. Loette, and J.L. Karr Prospective evaluation of topical antibiotics for preventing infections in uncomplicated soft-tissue wounds repaired in the ED Acad Emerg Med 2 1995 4 10
21. A.J. Singer, M. Mohammad, G. Tortora, H.C. Thode Jr., and S.A. McClain Octylcyanoacrylate for the treatment of contaminated partial-thickness burns in swine: a randomized controlled experiment Acad Emerg Med 7 2000 222 227