Prognostic relevance of p53 and bcl-2 immunoreactivity for early invasive pT1/pT2 gastric carcinomas: Indicators for limited gastric resections?

Surgical Endoscopy and Other Interventional Techniques

Volumn 19, Issue 11, 2005, Pages 1507-1512

  Kopp, R ^a   Diebold, J ^a   Dreier, I ^a   Cramer, C ^a   Glas, J ^a   Baretton, G ^a   Jauch, K W ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

bcl 2; Gastric cancer; p53

Indexed keywords

DNA FRAGMENT; PROTEIN BCL 2; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CLASSIFICATION; CANCER INVASION; CANCER SURVIVAL; CELL NUCLEUS; CONTROLLED STUDY; DISEASE ASSOCIATION; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; INTESTINE; MEDICAL PARAMETERS; MULTIVARIATE ANALYSIS; NICK END LABELING; PRIORITY JOURNAL; PROGNOSIS; STOMACH ADENOCARCINOMA; STOMACH CARCINOMA; SURVIVAL TIME; TUMOR CELL;

ADENOCARCINOMA; GASTRECTOMY; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS C-BCL-2; STOMACH NEOPLASMS; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 27944462708     PISSN: 09302794     EISSN: 14322218     Source Type: Journal    
DOI: 10.1007/s00464-005-0043-7     Document Type: Article

References (29)

1. Abdalla EK, Pfister PW (2004) Staging and preoperative evaluation of upper gastrointestinal malignancies. Semin Oncol 31: 513-529
2. Adachi Y, Shiraishi N, Kitano S (2002) Modern treatment of early gastric cancer: review of the Japanese experience. Dig Surg 19: 333-339
3. Baretton GB, Diebold J, Christoforis G, Vogt M, Müller Ch, Dopfer K, Schneiderbanger K, Schmidt M, Löhrs U (1996) Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Cancer 77: 255-264
4. Folli S, Dente M, DelĺAmore D, Gaudio M, Nanni O, Saragoni L, Vio A (1995) Early gastric cancer: prognostic factors in 223 patients. Br J Surg 82: 952-956
5. Fonseca L, Yonemura Y, De Arexabala X, Yamaguchi A, Miwa K, Miyazaki I (1994) p53 detection as a prognostic factor in early gastric cancer. Oncology 51: 485-490
6. Gabbert HE, Müller W, Schneiders A, Meier S, Hommel G (1995) The relationship of p53 expression to the prognosis of 418 patients with gastric carcinoma. Cancer 76: 720-726
7. Harris CC, Hollstein M (1993) Clinical implications of the p53 tumor suppressor gene. N Engl J Med 329: 1318-1326
8. Hockenberg DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ (1991) bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci U S A 88: 6961-6965
9. Ikeguchi M, Tatebe S, Kaibara N, Ito H (1977) Changes in levels of expression of p53 and the product of the bcl-2 in lines of gastric cancer cells during cisplatin-induced apoptosis. Eur Surg Res 29: 396-402
10. Kerr JFR, Winterford CM, Harmon BV (1994) Apoptosis: its significance in cancer and cancer therapy. Cancer 73: 2013-2036
11. Kim JP, Hur YS, Yang HK (1995) Lymph node metastasis as a significant prognostic factor in early gastric cancer: analysis of 1,136 early gastric cancers. Ann Surg Oncol 2: 308-313
12. Kim R, Emi M, Tanabe K, Toga T (2004) Preclinical evaluation of antisense bcl-2 as a chemosensitizer for patients with gastric carcinoma. Cancer 101: 2177-2186
13. Kroemer G (1997) The proto-oncogene bcl-2 and its role in regulating apoptosis. Nature Med 3: 614-620
14. Lauwers GY, Scott GV, Hendricks J (1994) Immunhistochemical evidence of aberrant bcl-2 protein expression in gastric epithelial dysplasia. Cancer 73: 2900-2904
15. Lauwers GY, Scott GV, Karpeh MS (1995) Immunhistochemical evaluation of bcl-2 protein expression in gastric adenocarcinomas. Cancer 75: 2209-2213
16. Lin J, Beerm DG (2004) Molecular biology of upper gastrointestinal malignancies. Semin Oncol 31: 476-486
17. Ludwig K, Wilhelm L, Scharlau U, Amtsberg G, Berhardt J (2002) Laparoscopic-endoscopic rendezvous resection of gastric tumors. Surg Endosc 16: 1561-1565
18. Miwa K, Miyazaki I, Sahara H, Fujimura T, Yonemura Y, Noguchi M, Falla R (1995) Rationale for extensive lymphadenectomie in early gastric carcinoma. Br J Cancer 72: 1518-1524
19. Rosch T (1995) Endosonographic staging of gastric cancer: a review of literature results. Gastrointest Endosc Clin North Am 5: 549-557
20. Ryu KW, Lee JH, Kim HS, Kim YW, Choi IJ, Bae JM (2003) Prediction of lymph node metastasis by sentinel node biopsy in gastric cancer. Eur J Surg Oncol 29: 895-899
21. Scartozzi M, Galizia E, Freddari F, Berardi R, Cellerino R, Cascinu S (2004) Molecular biology of sporadic gastric cancer: prognostic indicators and novel therapeutic approaches. Cancer Treat Rev 30: 451-459
22. Schlag PM, Bembenek A, Schulze T (2004) Sentinel node biopsy in gastrointestinal-tract cancer. Eur J Cancer 40: 2022-2032
23. Selivanova G, Iotsova V, Okan I, Fritsche M, Ström M, Groner B, Grafström RC, Wiman KG (1997) Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the 53 C-terminal domain. Nature Med 3: 632-638
24. Shimoyama S, Seto Y, Yasuda H, Mafune K, Kaminishi M (2005) Concepts, rationale, and current outcomes of less invasive surgical strategies for early gastric cancer: data from a quarter-century of experience in a single institution. World J Surg 29:58-65
25. Starzynska T, Bromley M, Gosh A, Stern PL (1992) Prognostic significance of p53 overexpression in gastric and colorectal carcinoma. Br J Cancer 66: 558-562
26. Tanaka K, Tonouchi H, Kobayashi M, Konishi N, Ohmori Y, Mohri Y, Kusunoki M (2004) Laparoscopically assisted total gastrectomy with sentinel node biopsy for early gastric cancer: preliminary results. Am Surg 70: 976-981
27. TNM (1997) Classification of malignant tumors. 5th ed. John Wiley & Sons, New York
28. Vogelstein B, Kinzler KW (1992) p53: function and dysfunction. Cell 70: 523-526
29. Yanai H, Matsumoto Y, Harada T, Nishiaki M, Tokiyama H, Shigemitsu T, Tada M, Okita K (1997) Endoscopic ultrasonography and endoscopy for staging depth of invasion in early gastric cancer: a pilot study. Gastrointest Endosc 46: 212-216